Brcc3 BRCA1/BRCA2-containing complex, subunit 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Brcc3provided by MGI
Official Full Name: BRCA1/BRCA2-containing complex, subunit 3provided by MGI
Primary source: MGI:MGI:2389572
See related: Ensembl:ENSMUSG00000031201 AllianceGenome:MGI:2389572
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C6.1A
Summary: Enables metal-dependent deubiquitinase activity. Involved in chromatin remodeling; positive regulation of NLRP3 inflammasome complex assembly; and protein K63-linked deubiquitination. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin ligase complex. Is expressed in central nervous system and genitourinary system. Orthologous to human BRCC3 (BRCA1/BRCA2-containing complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 5.2), liver E14 (RPKM 5.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 38.22 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (74460234..74499307)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (75416628..75455702)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BRCC36 regulates beta-catenin ubiquitination to alleviate vascular calcification in chronic kidney disease.
Title: BRCC36 regulates β-catenin ubiquitination to alleviate vascular calcification in chronic kidney disease.
BRCC36 promotes intestinal mucosal barrier injury caused by BMP2 after ischemia reperfusion via inhibiting PPARgamma signaling.
Title: BRCC36 promotes intestinal mucosal barrier injury caused by BMP2 after ischemia reperfusion via inhibiting PPARγ signaling.
BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells: Implication in Pulmonary Hypertension.
Title: BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells: Implication in Pulmonary Hypertension.
The deubiquitinase BRCC3 increases the stability of ZEB1 and promotes the proliferation and metastasis of triple-negative breast cancer cells.
Title: The deubiquitinase BRCC3 increases the stability of ZEB1 and promotes the proliferation and metastasis of triple-negative breast cancer cells.
BRCC3 mediates inflammation and pyroptosis in cerebral ischemia/reperfusion injury by activating the NLRP6 inflammasome.
Title: BRCC3 mediates inflammation and pyroptosis in cerebral ischemia/reperfusion injury by activating the NLRP6 inflammasome.
BRCC3-Mediated NLRP3 Deubiquitylation Promotes Inflammasome Activation and Atherosclerosis in Tet2 Clonal Hematopoiesis.
Title: BRCC3-Mediated NLRP3 Deubiquitylation Promotes Inflammasome Activation and Atherosclerosis in Tet2 Clonal Hematopoiesis.
Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3.
Title: Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3.
Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition.
Title: Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition.
The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson's disease models.
Title: The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson's disease models.
We report here for the first time that oxLDL-induced NLRP3 inflammasome stabilization and activation occurs due to modulation by BRCC36 activity in murine macrophages.
Title: Regulation of oxidized LDL-induced inflammatory process through NLRP3 inflammasome activation by the deubiquitinating enzyme BRCC36.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234787

px-70e7 (e-PCR)
- UniSTS:258155

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables K63-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables enzyme regulator activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metal-dependent deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal-dependent deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables metal-dependent deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metallopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables polyubiquitin modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair-dependent chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in DNA repair-dependent chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic G2/M transition checkpoint	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of DNA repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K63-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA damage checkpoint	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of DNA repair	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to X-ray	ISO Inferred from Sequence Orthology more info
involved_in response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in response to ionizing radiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of BRCA1-A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BRCA1-A complex	ISO Inferred from Sequence Orthology more info
part_of BRCA1-A complex	ISS Inferred from Sequence or Structural Similarity more info
part_of BRCA1-A complex	NAS Non-traceable Author Statement more info	PubMed
part_of BRISC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of BRISC complex	ISO Inferred from Sequence Orthology more info
part_of BRISC complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of nuclear ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
located_in spindle pole	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lys-63-specific deubiquitinase BRCC36

Names: 6.1A protein; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 36; BRISC complex subunit BRCC36

NP_001159929.1

EC 3.1.2.15

NP_001159931.1

EC 3.1.2.15

NP_001345665.1

EC 3.1.2.15

NP_001345666.1

EC 3.1.2.15

NP_666068.1

EC 3.1.2.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166457.1 → NP_001159929.1 lys-63-specific deubiquitinase BRCC36

See identical proteins and their annotated locations for NP_001159929.1

Status: VALIDATED

Source sequence(s)

AK149844, AL671860, BC048179

Consensus CDS

CCDS41031.1

UniProtKB/Swiss-Prot

A3KGA9, A8Y5K0, P46737, Q3UDZ4, Q9D025

Related

ENSMUSP00000033544.8, ENSMUST00000033544.14

Conserved Domains (1) summary

cd08068
Location:13 → 267

MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex
NM_001166459.1 → NP_001159931.1 lys-63-specific deubiquitinase BRCC36

See identical proteins and their annotated locations for NP_001159931.1

Status: VALIDATED

Source sequence(s)

AK011876, AL671860, CD774860

Consensus CDS

CCDS41031.1

UniProtKB/Swiss-Prot

A3KGA9, A8Y5K0, P46737, Q3UDZ4, Q9D025

Conserved Domains (1) summary

cd08068
Location:13 → 267

MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex
NM_001358736.1 → NP_001345665.1 lys-63-specific deubiquitinase BRCC36

Status: VALIDATED

Source sequence(s)

AL671860, CD774860

Consensus CDS

CCDS41031.1

UniProtKB/Swiss-Prot

A3KGA9, A8Y5K0, P46737, Q3UDZ4, Q9D025

Conserved Domains (1) summary

cd08068
Location:13 → 267

MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex
NM_001358737.1 → NP_001345666.1 lys-63-specific deubiquitinase BRCC36

Status: VALIDATED

Source sequence(s)

AL671860, BC048179

Consensus CDS

CCDS41031.1

UniProtKB/Swiss-Prot

A3KGA9, A8Y5K0, P46737, Q3UDZ4, Q9D025

Related

ENSMUSP00000109708.2, ENSMUST00000114074.8

Conserved Domains (1) summary

cd08068
Location:13 → 267

MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex
NM_145956.4 → NP_666068.1 lys-63-specific deubiquitinase BRCC36

See identical proteins and their annotated locations for NP_666068.1

Status: VALIDATED

Source sequence(s)

AK030736, AL671860, BC048179

Consensus CDS

CCDS41031.1

UniProtKB/Swiss-Prot

A3KGA9, A8Y5K0, P46737, Q3UDZ4, Q9D025

Conserved Domains (1) summary

cd08068
Location:13 → 267

MPN_BRCC36; Mov34/MPN/PAD-1 family: BRCC36, a subunit of BRCA1-A complex