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    Acrbp proacrosin binding protein [ Mus musculus (house mouse) ]

    Gene ID: 54137, updated on 9-Dec-2024

    Summary

    Official Symbol
    Acrbpprovided by MGI
    Official Full Name
    proacrosin binding proteinprovided by MGI
    Primary source
    MGI:MGI:1859515
    See related
    Ensembl:ENSMUSG00000072770 AllianceGenome:MGI:1859515
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sp32; OY-TES-1
    Summary
    Predicted to enable peptidase activator activity. Involved in acrosome assembly and fertilization. Located in acrosomal vesicle. Is expressed in testis. Orthologous to human ACRBP (acrosin binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 288.0) and thymus adult (RPKM 11.3) See more
    Orthologs
    NEW
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    Genomic context

    See Acrbp in Genome Data Viewer
    Location:
    6 59.17 cM; 6 F2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125026890..125040228)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125049927..125063265)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930557K07 gene Neighboring gene STARR-positive B cell enhancer ABC_E1711 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124959611-124959720 Neighboring gene zinc finger protein 384 Neighboring gene STARR-positive B cell enhancer ABC_E1071 Neighboring gene STARR-seq mESC enhancer starr_17323 Neighboring gene STARR-positive B cell enhancer ABC_E6489 Neighboring gene inhibitor of growth family, member 4 Neighboring gene lysophosphatidic acid receptor 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:125039823-125040010 Neighboring gene STARR-positive B cell enhancer ABC_E4864 Neighboring gene microRNA 7045 Neighboring gene chromodomain helicase DNA binding protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Clone Names

    • MGC74248

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase activator activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatid development ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in acrosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in acrosomal vesicle ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    acrosin-binding protein
    Names
    acrosin-binding protein, 60 kDa form

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127340.1NP_001120812.1  acrosin-binding protein isoform 2 precursor

      See identical proteins and their annotated locations for NP_001120812.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1, resulting in a protein (isoform 2) with a shorter, distinct C-terminus when compared to isoform 1.
      Source sequence(s)
      AV260707, BM938496, BY099028
      Consensus CDS
      CCDS51910.1
      UniProtKB/Swiss-Prot
      Q3V140
      Related
      ENSMUSP00000108033.2, ENSMUST00000112414.8
      Conserved Domains (1) summary
      pfam07222
      Location:1238
      PBP_sp32; Proacrosin binding protein sp32
    2. NM_016845.2NP_058541.2  acrosin-binding protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_058541.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK132705, BY099028
      Consensus CDS
      CCDS20542.1
      UniProtKB/Swiss-Prot
      Q3V140, Q62253, Q62254, Q8C621, Q91VQ1
      Related
      ENSMUSP00000085632.6, ENSMUST00000088294.12
      Conserved Domains (1) summary
      pfam07222
      Location:1238
      PBP_sp32; Proacrosin binding protein sp32

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      125026890..125040228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)