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    Acrbp proacrosin binding protein [ Mus musculus (house mouse) ]

    Gene ID: 54137, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acrbpprovided by MGI
    Official Full Name
    proacrosin binding proteinprovided by MGI
    Primary source
    MGI:MGI:1859515
    See related
    Ensembl:ENSMUSG00000072770 AllianceGenome:MGI:1859515
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sp32; OY-TES-1
    Summary
    Predicted to enable peptidase activator activity. Involved in acrosome assembly and fertilization. Located in acrosomal vesicle. Is expressed in testis. Orthologous to human ACRBP (acrosin binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 288.0) and thymus adult (RPKM 11.3) See more
    Orthologs
    human all
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    Genomic context

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    See Acrbp in Genome Data Viewer
    Location:
    6 59.17 cM; 6 F2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125026890..125040228)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125049927..125063265)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930557K07 gene Neighboring gene STARR-positive B cell enhancer ABC_E1711 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124959611-124959720 Neighboring gene zinc finger protein 384 Neighboring gene STARR-positive B cell enhancer ABC_E1071 Neighboring gene STARR-seq mESC enhancer starr_17323 Neighboring gene STARR-positive B cell enhancer ABC_E6489 Neighboring gene inhibitor of growth family, member 4 Neighboring gene lysophosphatidic acid receptor 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:125039823-125040010 Neighboring gene STARR-positive B cell enhancer ABC_E4864 Neighboring gene microRNA 7045 Neighboring gene chromodomain helicase DNA binding protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Behavior of ACRBP-deficient mouse sperm in the female reproductive tract. Nagashima K, et al. J Reprod Dev, 2019 Apr 12. PMID 30606959, Free PMC Article
    2. Proacrosin-deficient mice and zona pellucida modifications in an experimental model of multifactorial infertility. Nayernia K, et al. Mol Hum Reprod, 2002 May. PMID 11994540
    3. Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse. Kanemori Y, et al. Proc Natl Acad Sci U S A, 2016 Jun 28. PMID 27303034, Free PMC Article
    4. Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen. Ono T, et al. Proc Natl Acad Sci U S A, 2001 Mar 13. PMID 11248070, Free PMC Article
    5. The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice. Zuo X, et al. J Biol Chem, 2018 Jun 15. PMID 29716999, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Male subfertility of ACRBP-deficient mice may be attributed to incompleteness of the acrosome reaction rather than impairment in sperm migration from the uterus to the oviduct.
      Title: Behavior of ACRBP-deficient mouse sperm in the female reproductive tract.
    2. Setd2 deficiency results in complete loss of H3K36me3 and significantly decreases expression of thousands of genes, including those encoding acrosin-binding protein 1 (Acrbp1) and protamines, required for spermatogenesis.
      Title: The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice.
    3. ACRBP-null male mice showed a severely reduced fertility, because of malformation of the acrosome.
      Title: Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse.
    4. Two forms of Acrbp mRNA-wild-type Acrbp-W and variant Acrbp-V5 mRNAs-were generated by alternative splicing of Acrbp in the mouse.
      Title: Two functional forms of ACRBP/sp32 are produced by pre-mRNA alternative splicing in the mouse.
    5. Data suggest that the fertility defect in PCSK4 (proprotein convertase subtilisin/kexin type 4) knockout mice is due, in part, to altered processing/proteolysis of ACRBP as well as structural abnormalities in sperm heads and acrosomes.
      Title: Alteration in the processing of the ACRBP/sp32 protein and sperm head/acrosome malformations in proprotein convertase 4 (PCSK4) null mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC74248

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase activator activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatid development ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in acrosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in acrosomal vesicle ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    acrosin-binding protein
    Names
    acrosin-binding protein, 60 kDa form

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127340.1 → NP_001120812.1  acrosin-binding protein isoform 2 precursor

      See identical proteins and their annotated locations for NP_001120812.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1, resulting in a protein (isoform 2) with a shorter, distinct C-terminus when compared to isoform 1.
      Source sequence(s)
      AV260707, BM938496, BY099028
      Consensus CDS
      CCDS51910.1
      UniProtKB/Swiss-Prot
      Q3V140
      Related
      ENSMUSP00000108033.2, ENSMUST00000112414.8
      Conserved Domains (1) summary
      pfam07222
      Location:1 → 238
      PBP_sp32; Proacrosin binding protein sp32

    2. NM_016845.2 → NP_058541.2  acrosin-binding protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_058541.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK132705, BY099028
      Consensus CDS
      CCDS20542.1
      UniProtKB/Swiss-Prot
      Q3V140, Q62253, Q62254, Q8C621, Q91VQ1
      Related
      ENSMUSP00000085632.6, ENSMUST00000088294.12
      Conserved Domains (1) summary
      pfam07222
      Location:1 → 238
      PBP_sp32; Proacrosin binding protein sp32

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      125026890..125040228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V140.1 GenPept UniProtKB/Swiss-Prot:Q3V140

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