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    Mphosph8 M-phase phosphoprotein 8 [ Mus musculus (house mouse) ]

    Gene ID: 75339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mphosph8provided by MGI
    Official Full Name
    M-phase phosphoprotein 8provided by MGI
    Primary source
    MGI:MGI:1922589
    See related
    Ensembl:ENSMUSG00000079184 AllianceGenome:MGI:1922589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500035L22Rik; 4930548G07Rik
    Summary
    Predicted to enable chromatin binding activity and methylated histone binding activity. Predicted to be involved in negative regulation of gene expression via chromosomal CpG island methylation; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; and positive regulation of DNA methylation-dependent heterochromatin formation. Predicted to be located in several cellular components, including cytosol; heterochromatin; and nuclear lumen. Predicted to be part of nucleosome. Predicted to be active in cytoplasm and nucleus. Is expressed in inner cell mass and trophectoderm. Orthologous to human MPHOSPH8 (M-phase phosphoprotein 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 15.4), CNS E14 (RPKM 8.2) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mphosph8 in Genome Data Viewer
    Location:
    14 C3; 14 28.37 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56905692..56934887)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56668235..56697430)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) polymerase family, member 4 Neighboring gene predicted gene 16573 Neighboring gene STARR-positive B cell enhancer ABC_E755 Neighboring gene basic transcription factor 3, pseudogene 18 Neighboring gene predicted gene, 16973 Neighboring gene paraspeckle protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E9897 Neighboring gene predicted gene 4479

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MPP8 Governs the Activity of the LIF/STAT3 Pathway and Plays a Crucial Role in the Differentiation of Mouse Embryonic Stem Cells. Zhang H, et al. Cells, 2023 Aug 8. PMID 37626833, Free PMC Article
    2. Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia. Gu Z, et al. Nat Genet, 2021 May. PMID 33833453, Free PMC Article
    3. The HUSH complex controls brain architecture and protocadherin fidelity. Hagelkruys A, et al. Sci Adv, 2022 Nov 4. PMID 36332029, Free PMC Article
    4. Dual role of Fam208a during zygotic cleavage and early embryonic development. Gresakova V, et al. Exp Cell Res, 2021 Sep 15. PMID 34216590
    5. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Maier VK, et al. Mol Cell Proteomics, 2015 Jun. PMID 25680957, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MPP8 Governs the Activity of the LIF/STAT3 Pathway and Plays a Crucial Role in the Differentiation of Mouse Embryonic Stem Cells.
      Title: MPP8 Governs the Activity of the LIF/STAT3 Pathway and Plays a Crucial Role in the Differentiation of Mouse Embryonic Stem Cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone reader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in constitutive heterochromatin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of gene expression via chromosomal CpG island methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression via chromosomal CpG island methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transposable element silencing by heterochromatin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in heterochromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    M-phase phosphoprotein 8
    NP_001347001.1
    NP_076262.2
    XP_036014782.1
    XP_036014783.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360072.1 → NP_001347001.1  M-phase phosphoprotein 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154731, AK158773, BU757804, BY111264
      UniProtKB/TrEMBL
      Q9JJB4
      Conserved Domains (4) summary
      smart00298
      Location:58 → 109
      CHROMO; Chromatin organization modifier domain
      cd00204
      Location:605 → 729
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:613 → 641
      ANK; ANK repeat [structural motif]
      cl26511
      Location:97 → 482
      Neuromodulin_N; Gap junction protein N-terminal region

    2. NM_023773.2 → NP_076262.2  M-phase phosphoprotein 8 isoform 1

      See identical proteins and their annotated locations for NP_076262.2

      Status: VALIDATED

      Source sequence(s)
      AK158773, BU757804, BY111264
      Consensus CDS
      CCDS49504.1
      UniProtKB/Swiss-Prot
      A6H600, Q3TWY7, Q3TYA6
      UniProtKB/TrEMBL
      Q9JJB4
      Related
      ENSMUSP00000112170.2, ENSMUST00000116468.2
      Conserved Domains (4) summary
      smart00298
      Location:58 → 109
      CHROMO; Chromatin organization modifier domain
      cd00204
      Location:593 → 717
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:604 → 693
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:601 → 629
      ANK; ANK repeat [structural motif]

    RNA

    1. NR_153396.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BC145164, BU757804, BY111264

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      56905692..56934887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158889.1 → XP_036014782.1  M-phase phosphoprotein 8 isoform X1

      Conserved Domains (2) summary
      cd18633
      Location:58 → 108
      CD_MMP8; chromodomain of M-phase phosphoprotein 8
      NF037998
      Location:173 → 252
      RND_1; protein translocase

    2. XM_036158890.1 → XP_036014783.1  M-phase phosphoprotein 8 isoform X2

      UniProtKB/TrEMBL
      Q3ULG7
      Conserved Domains (2) summary
      PTZ00121
      Location:97 → 438
      PTZ00121; MAEBL; Provisional
      cd18633
      Location:58 → 108
      CD_MMP8; chromodomain of M-phase phosphoprotein 8

    RNA

    1. XR_383217.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TYA6.1 GenPept UniProtKB/Swiss-Prot:Q3TYA6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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