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    Tfr2 transferrin receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 50765, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tfr2provided by MGI
    Official Full Name
    transferrin receptor 2provided by MGI
    Primary source
    MGI:MGI:1354956
    See related
    Ensembl:ENSMUSG00000029716 AllianceGenome:MGI:1354956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trfr2
    Summary
    Predicted to enable co-receptor binding activity and transferrin receptor activity. Acts upstream of or within multicellular organismal-level iron ion homeostasis. Part of HFE-transferrin receptor complex. Is expressed in liver lobe; mesonephros; and urinary system. Used to study hemochromatosis type 3. Human ortholog(s) of this gene implicated in hemochromatosis and hemochromatosis type 3. Orthologous to human TFR2 (transferrin receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 109.9), liver E18 (RPKM 30.7) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tfr2 in Genome Data Viewer
    Location:
    5 G2; 5 76.57 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137568127..137586344)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137569822..137588081)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), beta 2 Neighboring gene predicted gene 17112 Neighboring gene actin-like 6B Neighboring gene STARR-positive B cell enhancer ABC_E2180 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:138038199-138038386 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:138041904-138042125 Neighboring gene STARR-positive B cell enhancer ABC_E281 Neighboring gene motile sperm domain containing 3 Neighboring gene predicted gene 7285

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables co-receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables co-receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferrin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferrin receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to iron ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to iron ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytic iron import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytic iron import into cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytic iron import into cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intracellular iron ion homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organismal-level iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptide hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptide hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to iron ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transferrin transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transferrin transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of HFE-transferrin receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of HFE-transferrin receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transferrin receptor protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289507.3NP_001276436.2  transferrin receptor protein 2

      Status: VALIDATED

      Source sequence(s)
      AC148018
      Consensus CDS
      CCDS39333.1
      UniProtKB/Swiss-Prot
      Q920I6, Q99MQ9, Q9CPT2, Q9JKX3
      Related
      ENSMUSP00000142502.2, ENSMUST00000198783.5
      Conserved Domains (3) summary
      cd02128
      Location:206396
      PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
      cd09848
      Location:404637
      M28_TfR; M28 Zn-peptidase Transferrin Receptor family
      pfam04253
      Location:664788
      TFR_dimer; Transferrin receptor-like dimerization domain
    2. NM_001289509.2NP_001276438.1  transferrin receptor protein 2

      See identical proteins and their annotated locations for NP_001276438.1

      Status: VALIDATED

      Source sequence(s)
      AC148018
      Consensus CDS
      CCDS39333.1
      UniProtKB/Swiss-Prot
      Q920I6, Q99MQ9, Q9CPT2, Q9JKX3
      Related
      ENSMUSP00000142478.2, ENSMUST00000199054.5
      Conserved Domains (3) summary
      cd02128
      Location:206396
      PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
      cd09848
      Location:404637
      M28_TfR; M28 Zn-peptidase Transferrin Receptor family
      pfam04253
      Location:664788
      TFR_dimer; Transferrin receptor-like dimerization domain
    3. NM_001289511.2NP_001276440.1  transferrin receptor protein 2

      See identical proteins and their annotated locations for NP_001276440.1

      Status: VALIDATED

      Source sequence(s)
      AC148018
      Consensus CDS
      CCDS39333.1
      UniProtKB/Swiss-Prot
      Q920I6, Q99MQ9, Q9CPT2, Q9JKX3
      Related
      ENSMUSP00000142814.2, ENSMUST00000196471.5
      Conserved Domains (3) summary
      cd02128
      Location:206396
      PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
      cd09848
      Location:404637
      M28_TfR; M28 Zn-peptidase Transferrin Receptor family
      pfam04253
      Location:664788
      TFR_dimer; Transferrin receptor-like dimerization domain
    4. NM_001359206.2NP_001346135.1  transferrin receptor protein 2

      Status: VALIDATED

      Source sequence(s)
      AC148018
      Consensus CDS
      CCDS39333.1
      UniProtKB/Swiss-Prot
      Q920I6, Q99MQ9, Q9CPT2, Q9JKX3
      Related
      ENSMUSP00000142720.2, ENSMUST00000198866.5
      Conserved Domains (3) summary
      cd02128
      Location:206396
      PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
      cd09848
      Location:404637
      M28_TfR; M28 Zn-peptidase Transferrin Receptor family
      pfam04253
      Location:664788
      TFR_dimer; Transferrin receptor-like dimerization domain
    5. NM_001425505.1NP_001412434.1  transferrin receptor protein 2

      Status: VALIDATED

      Source sequence(s)
      AC148018
      UniProtKB/Swiss-Prot
      Q920I6, Q99MQ9, Q9CPT2, Q9JKX3
    6. NM_001425506.1NP_001412435.1  transferrin receptor protein 2

      Status: VALIDATED

      Source sequence(s)
      AC148018
      UniProtKB/Swiss-Prot
      Q920I6, Q99MQ9, Q9CPT2, Q9JKX3
    7. NM_001425507.1NP_001412436.1  transferrin receptor protein 2

      Status: VALIDATED

      Source sequence(s)
      AC148018
      UniProtKB/Swiss-Prot
      Q920I6, Q99MQ9, Q9CPT2, Q9JKX3
    8. NM_015799.5NP_056614.3  transferrin receptor protein 2

      See identical proteins and their annotated locations for NP_056614.3

      Status: VALIDATED

      Source sequence(s)
      AC148018
      Consensus CDS
      CCDS39333.1
      UniProtKB/Swiss-Prot
      Q920I6, Q99MQ9, Q9CPT2, Q9JKX3
      Related
      ENSMUSP00000031729.9, ENSMUST00000031729.13
      Conserved Domains (3) summary
      cd02128
      Location:206396
      PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
      cd09848
      Location:404637
      M28_TfR; M28 Zn-peptidase Transferrin Receptor family
      pfam04253
      Location:664788
      TFR_dimer; Transferrin receptor-like dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137568127..137586344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_152864.1: Suppressed sequence

      Description
      NR_152864.1: This RefSeq has been removed because currently there is insufficient support for this transcript.