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    Ifi27 interferon, alpha-inducible protein 27 [ Mus musculus (house mouse) ]

    Gene ID: 52668, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ifi27provided by MGI
    Official Full Name
    interferon, alpha-inducible protein 27provided by MGI
    Primary source
    MGI:MGI:1277180
    See related
    Ensembl:ENSMUSG00000064215 AllianceGenome:MGI:1277180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ISG12a; Ifi27l1; D12Ertd647e; 1110013J02Rik; 2900026P10Rik
    Summary
    Predicted to enable several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; identical protein binding activity; and lamin binding activity. Acts upstream of or within regulation of protein export from nucleus. Predicted to be located in nuclear inner membrane. Predicted to be active in mitochondrial membrane. Is expressed in adrenal gland; heart valve; and testis. Orthologous to several human genes including IFI27 (interferon alpha inducible protein 27). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 234.6), mammary gland adult (RPKM 205.0) and 16 other tissues See more
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    Genomic context

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    See Ifi27 in Genome Data Viewer
    Location:
    12 E; 12 52.93 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103400448..103406504)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103434189..103440245)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4039 Neighboring gene DEAD box helicase 24 Neighboring gene STARR-positive B cell enhancer ABC_E2393 Neighboring gene STARR-seq mESC enhancer starr_33125 Neighboring gene STARR-positive B cell enhancer ABC_E2394 Neighboring gene predicted gene, 53758 Neighboring gene interferon, alpha-inducible protein 27 like 2A Neighboring gene predicted gene, 53759 Neighboring gene interferon, alpha-inducible protein 27 like 2B Neighboring gene STARR-positive B cell enhancer ABC_E7175 Neighboring gene protein phosphatase 4, regulatory subunit 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Immune response gene 1 deficiency impairs Nrf2 activation and aggravates liver fibrosis in mice. Fan K, et al. Biochem Biophys Res Commun, 2022 Jun 4. PMID 35367821
    2. Ifi27 is indispensable for mitochondrial function and browning in adipocytes. Jin W, et al. Biochem Biophys Res Commun, 2018 Jun 18. PMID 29730295
    3. Intervention of Inflammatory Monocyte Activity Limits Dermal Fibrosis. Haub J, et al. J Invest Dermatol, 2019 Oct. PMID 31039360
    4. ISG12 is a critical modulator of innate immune responses in murine models of sepsis. Uhrin P, et al. Immunobiology, 2013 Sep. PMID 23747037, Free PMC Article
    5. IFI27 Integrates Succinate and Fatty Acid Oxidation to Promote Adipocyte Thermogenic Adaption. Cui X, et al. Adv Sci (Weinh), 2023 Oct. PMID 37544897, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC149996

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lamin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in release of cytochrome c from mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interferon, alpha-inducible protein 27 like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364173.1 → NP_001351102.1  interferon, alpha-inducible protein 27 like 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154347
      Consensus CDS
      CCDS36529.1
      UniProtKB/TrEMBL
      Q70LN3, Q8C6G0
      Conserved Domains (1) summary
      pfam06140
      Location:134 → 210
      Ifi-6-16; Interferon-induced 6-16 family

    2. NM_001364174.1 → NP_001351103.1  interferon, alpha-inducible protein 27 like 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154347
      UniProtKB/TrEMBL
      Q70LN3
      Conserved Domains (1) summary
      pfam06140
      Location:114 → 190
      Ifi-6-16; Interferon-induced 6-16 family

    3. NM_026790.2 → NP_081066.2  interferon, alpha-inducible protein 27 like 1 isoform 1

      See identical proteins and their annotated locations for NP_081066.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK075797, BY130471, BY443016
      Consensus CDS
      CCDS36529.1
      UniProtKB/TrEMBL
      Q70LN3, Q8C6G0
      Related
      ENSMUSP00000082142.6, ENSMUST00000085065.12
      Conserved Domains (1) summary
      pfam06140
      Location:134 → 210
      Ifi-6-16; Interferon-induced 6-16 family

    4. NM_194066.2 → NP_919042.2  interferon, alpha-inducible protein 27 like 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame small exon in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK075797, BY130471, BY443016
      Consensus CDS
      CCDS36530.1
      UniProtKB/TrEMBL
      E9Q1C5, Q70LN2
      Related
      ENSMUSP00000078275.6, ENSMUST00000079294.12
      Conserved Domains (1) summary
      pfam06140
      Location:125 → 200
      Ifi-6-16; Interferon-induced 6-16 family

    5. NM_194067.2 → NP_919043.1  interferon, alpha-inducible protein 27 like 1 isoform 3

      See identical proteins and their annotated locations for NP_919043.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK003665, AK075797, BY130471, BY443016
      Consensus CDS
      CCDS26130.1
      UniProtKB/TrEMBL
      Q3UK07, Q9D1E1
      Related
      ENSMUSP00000068729.7, ENSMUST00000066701.13
      Conserved Domains (1) summary
      pfam06140
      Location:89 → 165
      Ifi-6-16; Interferon-induced 6-16 family

    6. NM_194068.2 → NP_919044.1  interferon, alpha-inducible protein 27 like 1 isoform 4

      See identical proteins and their annotated locations for NP_919044.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two exons in the CDS, as compared to variant 1. The reading frame is not affected and the resulting isoform (4) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK075797, BY130471, BY443016
      Consensus CDS
      CCDS26131.1
      UniProtKB/TrEMBL
      Q70LN0
      Related
      ENSMUSP00000075994.6, ENSMUST00000076702.12
      Conserved Domains (1) summary
      pfam06140
      Location:79 → 155
      Ifi-6-16; Interferon-induced 6-16 family

    7. NM_194069.2 → NP_919045.1  interferon, alpha-inducible protein 27 like 1 isoform 5

      See identical proteins and their annotated locations for NP_919045.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks three exons in the CDS, as compared to variant 1. The reading frame is not affected and the resulting isoform (5) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      BC125636, BY130468, BY443016
      Consensus CDS
      CCDS26132.1
      UniProtKB/TrEMBL
      Q70LM9
      Related
      ENSMUSP00000076068.6, ENSMUST00000076788.12
      Conserved Domains (1) summary
      pfam06140
      Location:40 → 115
      Ifi-6-16; Interferon-induced 6-16 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      103400448..103406504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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