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    Tmem184b transmembrane protein 184b [ Mus musculus (house mouse) ]

    Gene ID: 223693, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem184bprovided by MGI
    Official Full Name
    transmembrane protein 184bprovided by MGI
    Primary source
    MGI:MGI:2445179
    See related
    Ensembl:ENSMUSG00000009035 AllianceGenome:MGI:2445179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610507A11; 4732495E13Rik
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be active in membrane. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human TMEM184B (transmembrane protein 184B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 33.0), adrenal adult (RPKM 25.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem184b in Genome Data Viewer
    Location:
    15 E1; 15 37.7 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79244884..79287503, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79360684..79403303, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group VI Neighboring gene STARR-positive B cell enhancer ABC_E7389 Neighboring gene predicted gene 20420 Neighboring gene STARR-positive B cell enhancer ABC_E1913 Neighboring gene STARR-seq mESC enhancer starr_39174 Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) Neighboring gene microRNA 1943 Neighboring gene STARR-seq mESC enhancer starr_39180 Neighboring gene STARR-seq mESC enhancer starr_39181 Neighboring gene casein kinase 1, epsilon Neighboring gene predicted gene 16059 Neighboring gene STARR-seq mESC enhancer starr_39185 Neighboring gene STARR-seq mESC enhancer starr_39186 Neighboring gene predicted gene, 41359

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transmembrane protein 184B (TMEM184B) promotes expression of synaptic gene networks in the mouse hippocampus. Wright EB, et al. BMC Genomics, 2023 Sep 20. PMID 37730546, Free PMC Article
    2. TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance. Bhattacharya MR, et al. J Neurosci, 2016 Apr 27. PMID 27122027, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transmembrane protein 184B (TMEM184B) promotes expression of synaptic gene networks in the mouse hippocampus.
      Title: Transmembrane protein 184B (TMEM184B) promotes expression of synaptic gene networks in the mouse hippocampus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 184B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253817.1 → NP_001240746.1  transmembrane protein 184B isoform 1

      See identical proteins and their annotated locations for NP_001240746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1) .
      Source sequence(s)
      BC046959, CO812629
      Consensus CDS
      CCDS27639.1
      UniProtKB/Swiss-Prot
      Q3TY97, Q8BG09, Q8BJ02
      Related
      ENSMUSP00000136416.2, ENSMUST00000178522.3
      Conserved Domains (1) summary
      pfam03619
      Location:46 → 317
      Solute_trans_a; Organic solute transporter Ostalpha

    2. NM_001253819.1 → NP_001240748.1  transmembrane protein 184B isoform 2

      See identical proteins and their annotated locations for NP_001240748.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an additional in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) is longer than isoform 1.
      Source sequence(s)
      AA240987, AK048138, BY152403
      Consensus CDS
      CCDS88803.1
      UniProtKB/TrEMBL
      A0A2I3BQI5
      Related
      ENSMUSP00000154210.2, ENSMUST00000228002.2
      Conserved Domains (1) summary
      pfam03619
      Location:46 → 317
      Solute_trans_a; Organic solute transporter Ostalpha

    3. NM_001253820.1 → NP_001240749.1  transmembrane protein 184B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two exons in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK149366, CX239857
      UniProtKB/TrEMBL
      A0A2R8VI00
      Conserved Domains (1) summary
      pfam03619
      Location:9 → 177
      Solute_trans_a; Organic solute transporter Ostalpha

    4. NM_001378998.1 → NP_001365927.1  transmembrane protein 184B isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC165278
      Conserved Domains (1) summary
      pfam03619
      Location:75 → 346
      Solute_trans_a; Organic solute transporter Ostalpha

    5. NM_172608.1 → NP_766196.1  transmembrane protein 184B isoform 1

      See identical proteins and their annotated locations for NP_766196.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the predominant transcript and encodes a 407aa isoform (1).
      Source sequence(s)
      AA240987, AK029129, BY275319
      Consensus CDS
      CCDS27639.1
      UniProtKB/Swiss-Prot
      Q3TY97, Q8BG09, Q8BJ02
      Related
      ENSMUSP00000074518.3, ENSMUST00000074991.10
      Conserved Domains (1) summary
      pfam03619
      Location:46 → 317
      Solute_trans_a; Organic solute transporter Ostalpha

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79244884..79287503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159354.1 → XP_036015247.1  transmembrane protein 184B isoform X6

      UniProtKB/TrEMBL
      A0A2R8VI00
      Related
      ENSMUSP00000155585.2, ENSMUST00000231076.2
      Conserved Domains (1) summary
      pfam03619
      Location:18 → 177
      Solute_trans_a; Organic solute transporter Ostalpha

    2. XM_006520805.4 → XP_006520868.1  transmembrane protein 184B isoform X1

      Conserved Domains (1) summary
      pfam03619
      Location:75 → 346
      Solute_trans_a; Organic solute transporter Ostalpha

    3. XM_036159353.1 → XP_036015246.1  transmembrane protein 184B isoform X3

      UniProtKB/Swiss-Prot
      Q3TY97, Q8BG09, Q8BJ02
      Conserved Domains (1) summary
      pfam03619
      Location:46 → 317
      Solute_trans_a; Organic solute transporter Ostalpha

    4. XM_006520806.4 → XP_006520869.1  transmembrane protein 184B isoform X2

      See identical proteins and their annotated locations for XP_006520869.1

      UniProtKB/TrEMBL
      A0A2I3BQI5
      Conserved Domains (1) summary
      pfam03619
      Location:46 → 317
      Solute_trans_a; Organic solute transporter Ostalpha

    5. XM_030248501.2 → XP_030104361.1  transmembrane protein 184B isoform X5

      Conserved Domains (1) summary
      pfam03619
      Location:33 → 231
      Solute_trans_a; Organic solute transporter Ostalpha

    6. XM_006520807.5 → XP_006520870.1  transmembrane protein 184B isoform X4

      Conserved Domains (1) summary
      pfam03619
      Location:1 → 251
      Solute_trans_a; Organic solute transporter Ostalpha

    7. XM_006520810.4 → XP_006520873.1  transmembrane protein 184B isoform X7

      Conserved Domains (1) summary
      pfam03619
      Location:23 → 165
      Solute_trans_a; Organic solute transporter Ostalpha
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG09.1 GenPept UniProtKB/Swiss-Prot:Q8BG09

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