Usp37 ubiquitin specific peptidase 37 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp37provided by MGI
Official Full Name: ubiquitin specific peptidase 37provided by MGI
Primary source: MGI:MGI:2442483
See related: Ensembl:ENSMUSG00000033364 AllianceGenome:MGI:2442483
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4932415L06Rik; C330008N13Rik
Summary: Predicted to enable cysteine-type deubiquitinase activity; cysteine-type endopeptidase activity; and protein kinase binding activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; protein deubiquitination; and regulation of protein stability. Predicted to be located in chromosome. Predicted to be active in cytosol and nucleus. Orthologous to human USP37 (ubiquitin specific peptidase 37). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in duodenum adult (RPKM 7.5), small intestine adult (RPKM 7.5) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C3- C4; 1 38.54 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (74474669..74583447, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (74435510..74544286, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37.
Title: Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit181 (e-PCR), detects polymorphism
- UniSTS:128520

AI593551 (e-PCR)
- UniSTS:164120

Vil (e-PCR), detects polymorphism
- UniSTS:144756

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in protein K11-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K11-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K48-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 37

Names: deubiquitinating enzyme 37; ubiquitin specific protease 37; ubiquitin thioesterase 37; ubiquitin thiolesterase 37; ubiquitin-specific-processing protease 37

NP_001297591.1

EC 3.4.19.12

NP_795946.2

EC 3.4.19.12

XP_006496117.1

EC 3.4.19.12

XP_006496120.1

EC 3.4.19.12

XP_036021582.1

EC 3.4.19.12

XP_036021584.1

EC 3.4.19.12

XP_036021585.1

EC 3.4.19.12

XP_036021586.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310662.1 → NP_001297591.1 ubiquitin carboxyl-terminal hydrolase 37 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC098570, AK030013, AK035640, BB624535

Consensus CDS

CCDS78616.1

UniProtKB/Swiss-Prot

B2RT12, Q69ZF6, Q8BZE6, Q8C0R0

Related

ENSMUSP00000035445.6, ENSMUST00000044260.11

Conserved Domains (4) summary

cd02257
Location:342 → 601

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

cl02553
Location:342 → 449

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:342 → 600

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 104

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
NM_176972.4 → NP_795946.2 ubiquitin carboxyl-terminal hydrolase 37 isoform 1

See identical proteins and their annotated locations for NP_795946.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC098570, AK030013, BC139091

Consensus CDS

CCDS15050.1

UniProtKB/Swiss-Prot

B2RT12, Q69ZF6, Q8BZE6, Q8C0R0

UniProtKB/TrEMBL

A0A0R4J2D0

Related

ENSMUSP00000140670.2, ENSMUST00000189257.7

Conserved Domains (3) summary

cd02257
Location:886 → 949

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:342 → 601

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 105

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

74474669..74583447 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165692.1 → XP_036021585.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X1

UniProtKB/Swiss-Prot

B2RT12, Q69ZF6, Q8BZE6, Q8C0R0

UniProtKB/TrEMBL

A0A0R4J2D0

Conserved Domains (3) summary

cd02257
Location:886 → 949

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:342 → 601

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 105

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
XM_006496057.5 → XP_006496120.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X2

UniProtKB/Swiss-Prot

B2RT12, Q69ZF6, Q8BZE6, Q8C0R0

Conserved Domains (3) summary

COG5207
Location:342 → 936

UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]

pfam00443
Location:342 → 601

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 105

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
XM_006496054.4 → XP_006496117.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X1

See identical proteins and their annotated locations for XP_006496117.1

UniProtKB/Swiss-Prot

B2RT12, Q69ZF6, Q8BZE6, Q8C0R0

UniProtKB/TrEMBL

A0A0R4J2D0

Conserved Domains (3) summary

cd02257
Location:886 → 949

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:342 → 601

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 105

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
XM_036165691.1 → XP_036021584.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X1

UniProtKB/Swiss-Prot

B2RT12, Q69ZF6, Q8BZE6, Q8C0R0

UniProtKB/TrEMBL

A0A0R4J2D0

Conserved Domains (3) summary

cd02257
Location:886 → 949

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:342 → 601

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 105

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
XM_036165689.1 → XP_036021582.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X1

UniProtKB/Swiss-Prot

B2RT12, Q69ZF6, Q8BZE6, Q8C0R0

UniProtKB/TrEMBL

A0A0R4J2D0

Conserved Domains (3) summary

cd02257
Location:886 → 949

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:342 → 601

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 105

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
XM_036165693.1 → XP_036021586.1 ubiquitin carboxyl-terminal hydrolase 37 isoform X3

UniProtKB/Swiss-Prot

B2RT12, Q69ZF6, Q8BZE6, Q8C0R0

Conserved Domains (2) summary

pfam00443
Location:342 → 601

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam16674
Location:3 → 105

UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37