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    Creb3l2 cAMP responsive element binding protein 3-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 208647, updated on 9-Dec-2024

    Summary

    Official Symbol
    Creb3l2provided by MGI
    Official Full Name
    cAMP responsive element binding protein 3-like 2provided by MGI
    Primary source
    MGI:MGI:2442695
    See related
    Ensembl:ENSMUSG00000038648 AllianceGenome:MGI:2442695
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BBF2H7; SCIRR69; C530025K05Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and cAMP response element binding activity. Involved in chondrocyte differentiation; endoplasmic reticulum to Golgi vesicle-mediated transport; and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; nucleoplasm; and perinuclear endoplasmic reticulum. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Orthologous to human CREB3L2 (cAMP responsive element binding protein 3 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 19.4), adrenal adult (RPKM 18.8) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Creb3l2 in Genome Data Viewer
    Location:
    6 B1; 6 16.18 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (37307956..37419083, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (37327255..37442276, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, iota Neighboring gene predicted gene, 52857 Neighboring gene STARR-seq mESC enhancer starr_15575 Neighboring gene predicted pseudogene 7452 Neighboring gene STARR-seq mESC enhancer starr_15579 Neighboring gene STARR-positive B cell enhancer mm9_chr6:37392120-37392421 Neighboring gene STARR-positive B cell enhancer ABC_E4821 Neighboring gene predicted gene, 33275 Neighboring gene predicted gene, 33318 Neighboring gene STARR-seq mESC enhancer starr_15587 Neighboring gene predicted gene, 33429 Neighboring gene aldo-keto reductase family 1, member D1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclic AMP-responsive element-binding protein 3-like protein 2
    Names
    cAMP-responsive element-binding protein 3-like protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178661.4NP_848776.2  cyclic AMP-responsive element-binding protein 3-like protein 2

      See identical proteins and their annotated locations for NP_848776.2

      Status: VALIDATED

      Source sequence(s)
      AK036712, BC138471, BY202578
      Consensus CDS
      CCDS20006.1
      UniProtKB/Swiss-Prot
      B2RRL0, Q8BH52, Q8CB61, Q8CBN2
      Related
      ENSMUSP00000040208.6, ENSMUST00000041093.6
      Conserved Domains (1) summary
      cd14689
      Location:305348
      bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      37307956..37419083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)