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    Plekhn1 pleckstrin homology domain containing, family N member 1 [ Mus musculus (house mouse) ]

    Gene ID: 231002, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plekhn1provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family N member 1provided by MGI
    Primary source
    MGI:MGI:2387630
    See related
    Ensembl:ENSMUSG00000078485 AllianceGenome:MGI:2387630
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clpabp
    Summary
    Predicted to enable phospholipid binding activity. Involved in 3'-UTR-mediated mRNA destabilization. Located in mitochondrion. Orthologous to human PLEKHN1 (pleckstrin homology domain containing N1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in stomach adult (RPKM 22.9), thymus adult (RPKM 14.5) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plekhn1 in Genome Data Viewer
    Location:
    4 E2; 4 88.63 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156305913..156312999, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (156221456..156228542, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2735 Neighboring gene expressed sequence AW011738 Neighboring gene PPARGC1 and ESRR induced regulator, muscle 1 Neighboring gene predicted gene, 46877 Neighboring gene kelch-like 17 Neighboring gene microRNA 7658 Neighboring gene STARR-seq mESC enhancer starr_12292 Neighboring gene NOC2 like nucleolar associated transcriptional repressor Neighboring gene predicted gene, 52691

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse. Nishino T, et al. Biochim Biophys Acta, 2016 Nov. PMID 27616329
    2. Bioinformatics and cellular signaling. Papin J, et al. Curr Opin Biotechnol, 2004 Feb. PMID 15102471
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cardiolipin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cardiolipin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cardiolipin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 3'-UTR-mediated mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 3'-UTR-mediated mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable pleckstrin homology domain-containing family N member 1
    Names
    PH domain-containing family N member 1
    cardiolipin and phosphatidic acid-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008233.3 → NP_001008234.2  probable pleckstrin homology domain-containing family N member 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CAAA01066807
      Consensus CDS
      CCDS51407.1
      UniProtKB/TrEMBL
      E9QP36
      Related
      ENSMUSP00000101196.3, ENSMUST00000105571.4
      Conserved Domains (2) summary
      pfam00169
      Location:243 → 322
      PH; PH domain
      cl17171
      Location:223 → 341
      PH-like; Pleckstrin homology-like domain

    2. NM_001368639.1 → NP_001355568.1  probable pleckstrin homology domain-containing family N member 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CAAA01066807
      Consensus CDS
      CCDS89875.1
      UniProtKB/Swiss-Prot
      A0A1W2P6Q7, A0A1W2P7X5, Q8C886, Q8R3H1
      Related
      ENSMUSP00000151799.2, ENSMUST00000217885.2
      Conserved Domains (1) summary
      cl17171
      Location:223 → 341
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      156305913..156312999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C886.2 GenPept UniProtKB/Swiss-Prot:Q8C886

    Gene LinkOut

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