U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Dlst dihydrolipoamide S-succinyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 78920, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dlstprovided by MGI
    Official Full Name
    dihydrolipoamide S-succinyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1926170
    See related
    Ensembl:ENSMUSG00000004789 AllianceGenome:MGI:1926170
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DLTS; 1600017E01Rik; 4632413C10Rik; 4930529O08Rik
    Summary
    Predicted to enable dihydrolipoyllysine-residue succinyltransferase activity; heat shock protein binding activity; and protein-folding chaperone binding activity. Predicted to be involved in 2-oxoglutarate metabolic process; nucleoside phosphate metabolic process; and tricarboxylic acid cycle. Located in mitochondrion and myelin sheath. Part of oxoglutarate dehydrogenase complex. Is expressed in several structures, including alimentary system; metanephros; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 165.8), kidney adult (RPKM 107.4) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dlst in Genome Data Viewer
    Location:
    12 D1; 12 39.55 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (85157597..85180865)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (85110822..85134091)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1446 Neighboring gene STARR-seq mESC enhancer starr_32760 Neighboring gene YLP motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_32761 Neighboring gene STARR-seq mESC enhancer starr_32762 Neighboring gene prospero homeobox 2 opposite strand Neighboring gene prospero homeobox 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86464102-86464289 Neighboring gene ribosomal protein S6 kinase-like 1 Neighboring gene STARR-seq mESC enhancer starr_32766 Neighboring gene placental growth factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables dihydrolipoyllysine-residue succinyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dihydrolipoyllysine-residue succinyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dihydrolipoyllysine-residue succinyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in 2-oxoglutarate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in L-lysine catabolic process to acetyl-CoA via saccharopine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in NADH metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in succinyl-CoA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tricarboxylic acid cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of oxoadipate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of oxoglutarate dehydrogenase complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of oxoglutarate dehydrogenase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of oxoglutarate dehydrogenase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
    Names
    2-oxoglutarate dehydrogenase complex component E2
    E2K
    OGDC-E2
    dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
    dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex
    NP_084501.1
    XP_006516455.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030225.4NP_084501.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

      See identical proteins and their annotated locations for NP_084501.1

      Status: VALIDATED

      Source sequence(s)
      AK158877, AK168570, CJ308553
      Consensus CDS
      CCDS26052.1
      UniProtKB/Swiss-Prot
      Q3UEA0, Q4FK55, Q8CIE8, Q9D2G2
      Related
      ENSMUSP00000060346.9, ENSMUST00000053811.10
      Conserved Domains (3) summary
      cd06849
      Location:72144
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      TIGR01347
      Location:72454
      sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
      pfam00198
      Location:239452
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      85157597..85180865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516392.5XP_006516455.1  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1

      Conserved Domains (1) summary
      TIGR01347
      Location:72453
      sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)