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    Aqp11 aquaporin 11 [ Mus musculus (house mouse) ]

    Gene ID: 66333, updated on 27-Nov-2024

    Summary

    Official Symbol
    Aqp11provided by MGI
    Official Full Name
    aquaporin 11provided by MGI
    Primary source
    MGI:MGI:1913583
    See related
    Ensembl:ENSMUSG00000042797 AllianceGenome:MGI:1913583
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sjds; 1700015P13Rik
    Summary
    Enables water channel activity. Involved in several processes, including intracellular oxygen homeostasis; intracellular water homeostasis; and negative regulation of ERAD pathway. Acts upstream of or within with a positive effect on protein glycosylation. Acts upstream of or within endosomal lumen acidification; kidney development; and water transport. Located in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and submandibular gland primordium. Orthologous to human AQP11 (aquaporin 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 412.2), thymus adult (RPKM 162.8) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Aqp11 in Genome Data Viewer
    Location:
    7 E1; 7 53.57 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (97375586..97387454, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (97726379..97738247, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene remodeling and spacing factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E11361 Neighboring gene remodeling and spacing factor 1, opposite strand 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:104870902-104871089 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:104872316-104872580 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:104879154-104879355 Neighboring gene chloride channel, nucleotide-sensitive, 1A Neighboring gene STARR-seq mESC enhancer starr_19606 Neighboring gene STARR-seq mESC enhancer starr_19609 Neighboring gene p21 (RAC1) activated kinase 1 Neighboring gene STARR-seq mESC enhancer starr_19614 Neighboring gene STARR-seq mESC enhancer starr_19615 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene ubiquinol-cytochrome c reductase complex chaperone, CBP3 homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    sudden juvenile death syndrome
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC144511, MGC144512

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glycerol channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycerol channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables hydrogen peroxide channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables water channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables water channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within endosomal lumen acidification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycerol transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycerol transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hydrogen peroxide transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hydrogen peroxide transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular oxygen homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular water homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular water homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within_positive_effect protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within proximal tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proximal tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within water transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in water transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    aquaporin-11
    Names
    AQP-11
    CG12251 gene product

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175105.3NP_780314.1  aquaporin-11

      See identical proteins and their annotated locations for NP_780314.1

      Status: PROVISIONAL

      Source sequence(s)
      AK075757
      Consensus CDS
      CCDS21463.1
      UniProtKB/Swiss-Prot
      Q8BHH1, Q8JZU1
      UniProtKB/TrEMBL
      Q8BYF0
      Related
      ENSMUSP00000146215.2, ENSMUST00000206389.2
      Conserved Domains (1) summary
      cl00200
      Location:46257
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      97375586..97387454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)