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    Dnajc11 DnaJ heat shock protein family (Hsp40) member C11 [ Mus musculus (house mouse) ]

    Gene ID: 230935, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dnajc11provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C11provided by MGI
    Primary source
    MGI:MGI:2443386
    See related
    Ensembl:ENSMUSG00000039768 AllianceGenome:MGI:2443386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E030019A03Rik
    Summary
    Involved in cristae formation. Located in mitochondrial inner membrane. Is expressed in submandibular gland primordium. Orthologous to human DNAJC11 (DnaJ heat shock protein family (Hsp40) member C11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 12.4), placenta adult (RPKM 11.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnajc11 in Genome Data Viewer
    Location:
    4 E2; 4 82.77 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152018177..152066416)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (151933720..151981959)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene calmodulin binding transcription activator 1 Neighboring gene predicted gene, 52710 Neighboring gene RIKEN cDNA 9230110K08 gene Neighboring gene STARR-positive B cell enhancer ABC_E30 Neighboring gene predicted gene, 42357 Neighboring gene THAP domain containing, apoptosis associated protein 3 Neighboring gene PHD finger protein 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice. Violitzi F, et al. J Proteome Res, 2019 Nov 1. PMID 31550165
    2. Identification and characterization of FLJ10737 and CAMTA1 genes on the commonly deleted region of neuroblastoma at human chromosome 1p36.31-p36.23. Katoh M, et al. Int J Oncol, 2003 Oct. PMID 12964007
    3. A splicing mutation in the novel mitochondrial protein DNAJC11 causes motor neuron pathology associated with cristae disorganization, and lymphoid abnormalities in mice. Ioakeimidis F, et al. PLoS One, 2014. PMID 25111180, Free PMC Article
    4. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
    5. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice.
      Title: Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice.
    2. a link between DNAJC11 and neuromuscular diseases
      Title: A splicing mutation in the novel mitochondrial protein DNAJC11 causes motor neuron pathology associated with cristae disorganization, and lymphoid abnormalities in mice.
    3. E030019A03 is the mouse ortholog of human FLJ10737, consisting of the DnaJ domain, bipartite nuclear localization signal (NLS), FADH domain, and FEMCA domain.
      Title: Identification and characterization of FLJ10737 and CAMTA1 genes on the commonly deleted region of neuroblastoma at human chromosome 1p36.31-p36.23.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cristae formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cristae formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MICOS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MICOS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SAM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SAM complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 11
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172704.3 → NP_766292.2  dnaJ homolog subfamily C member 11

      See identical proteins and their annotated locations for NP_766292.2

      Status: VALIDATED

      Source sequence(s)
      AK053156, BY784439, DV663024
      Consensus CDS
      CCDS18981.2
      UniProtKB/Swiss-Prot
      A2A8C9, Q5U458, Q8BP83, Q8C1Z4, Q8C6U5
      Related
      ENSMUSP00000051643.5, ENSMUST00000062904.11
      Conserved Domains (3) summary
      pfam00226
      Location:14 → 79
      DnaJ; DnaJ domain
      pfam06936
      Location:372 → 447
      Selenoprotein_S; Selenoprotein S (SelS)
      pfam11875
      Location:417 → 549
      DUF3395; Domain of unknown function (DUF3395)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      152018177..152066416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253511.2 → XP_030109371.1  dnaJ homolog subfamily C member 11 isoform X1

      Conserved Domains (1) summary
      pfam11875
      Location:131 → 270
      DUF3395; Domain of unknown function (DUF3395)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U458.2 GenPept UniProtKB/Swiss-Prot:Q5U458

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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