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    Aurka aurora kinase A [ Mus musculus (house mouse) ]

    Gene ID: 20878, updated on 27-Nov-2024

    Summary

    Official Symbol
    Aurkaprovided by MGI
    Official Full Name
    aurora kinase Aprovided by MGI
    Primary source
    MGI:MGI:894678
    See related
    Ensembl:ENSMUSG00000027496 AllianceGenome:MGI:894678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IAK; Ark1; Ayk1; IAK1; Stk6; AIRK1; ARK-1; Aurora-A
    Summary
    Enables histone H3S10 kinase activity and ubiquitin protein ligase binding activity. Acts upstream of or within several processes, including microtubule cytoskeleton organization; positive regulation of oocyte maturation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in axon hillock; microtubule cytoskeleton; and nucleus. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; bone; brain; eye; and genitourinary system. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine cancer. Orthologous to human AURKA (aurora kinase A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14.5 (RPKM 39.2), liver E14 (RPKM 37.7) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Aurka in Genome Data Viewer
    Location:
    2 H3; 2 94.84 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (172198116..172212825, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (172356190..172370886, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14273 Neighboring gene family with sequence similarity 210, member B Neighboring gene cleavage stimulation factor, 3' pre-RNA, subunit 1 Neighboring gene STARR-seq mESC enhancer starr_06572 Neighboring gene STARR-positive B cell enhancer ABC_E823 Neighboring gene Cas scaffolding protein family member 4 Neighboring gene uncharacterized LOC118568483 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:172259262-172259485 Neighboring gene STARR-positive B cell enhancer ABC_E3425 Neighboring gene replication termination factor 2 Neighboring gene glucosaminyl (N-acetyl) transferase family member 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular function activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within centrosome cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within liver regeneration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within meiotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within microtubule cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitotic centrosome separation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within mitotic centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of spindle checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial fission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to wounding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within spindle assembly involved in female meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon hillock IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in germinal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule organizing center IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    located_in pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle pole centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle pole centrosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    aurora kinase A
    Names
    aurora 2
    aurora A
    aurora family kinase 1
    aurora-related kinase 1
    aurora/IPL1-related kinase 1
    ipl1- and aurora-related kinase 1
    serine/threonine kinase 6
    serine/threonine-protein kinase 15
    serine/threonine-protein kinase 6
    serine/threonine-protein kinase Ayk1
    serine/threonine-protein kinase aurora-A
    NP_001278114.1
    NP_001408052.1
    NP_001408053.1
    NP_001408054.1
    NP_001408055.1
    NP_001408056.1
    NP_035627.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291185.2NP_001278114.1  aurora kinase A isoform b

      See identical proteins and their annotated locations for NP_001278114.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in its 5' terminal exon, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
      Source sequence(s)
      AL833787, AL844162
      Consensus CDS
      CCDS71204.1
      UniProtKB/Swiss-Prot
      O35624, P97477, Q8C3H8, Q91YU4
      UniProtKB/TrEMBL
      Q3TEY6, Q7TNK2
      Related
      ENSMUSP00000104768.4, ENSMUST00000109140.10
      Conserved Domains (1) summary
      cl21453
      Location:118374
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001421123.1NP_001408052.1  aurora kinase A isoform c

      Status: VALIDATED

      Source sequence(s)
      AL833787, AL844162
    3. NM_001421124.1NP_001408053.1  aurora kinase A isoform b

      Status: VALIDATED

      Source sequence(s)
      AL833787, AL844162
      UniProtKB/Swiss-Prot
      O35624, P97477, Q8C3H8, Q91YU4
      UniProtKB/TrEMBL
      Q3TEY6
    4. NM_001421125.1NP_001408054.1  aurora kinase A isoform d

      Status: VALIDATED

      Source sequence(s)
      AL833787, AL844162
    5. NM_001421126.1NP_001408055.1  aurora kinase A isoform e

      Status: VALIDATED

      Source sequence(s)
      AL833787, AL844162
    6. NM_001421127.1NP_001408056.1  aurora kinase A isoform f

      Status: VALIDATED

      Source sequence(s)
      AL833787, AL844162
    7. NM_011497.5NP_035627.1  aurora kinase A isoform a

      See identical proteins and their annotated locations for NP_035627.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AL833787, AL844162
      Consensus CDS
      CCDS17129.1
      UniProtKB/TrEMBL
      Q7TNK2
      Related
      ENSMUSP00000028997.8, ENSMUST00000028997.8
      Conserved Domains (2) summary
      smart00220
      Location:146396
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14116
      Location:140396
      STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase

    RNA

    1. NR_185245.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL833787, AL844162

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      172198116..172212825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)