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    Rdl Resistant to dieldrin [ Anopheles gambiae (African malaria mosquito) ]

    Gene ID: 1276697, updated on 22-Jun-2024

    Summary

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    Gene symbol
    Rdl
    Gene description
    Resistant to dieldrin
    See related
    VectorBase:AGAMI1_011163
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Anopheles gambiae
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Anophelinae; Anopheles
    Also known as
    AGAP006028
    Orthologs
    fruit fly all
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    Genomic context

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    See Rdl in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_12 current idAnoGambNW_F1_1 (GCF_943734735.2) 2 NC_064601.1 (94255896..94341446)

    Chromosome 2 - NC_064601.1Genomic Context describing neighboring genes Neighboring gene glutamate receptor 1 Neighboring gene glutamate receptor 1 Neighboring gene uncharacterized LOC1276699 Neighboring gene uncharacterized LOC5667353 Neighboring gene mitochondrial iron transporter mitoferrin Neighboring gene nuclear pore complex protein Nup54

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_064601.1 Chromosome 2 Reference idAnoGambNW_F1_1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The neonicotinoid imidacloprid, and the pyrethroid deltamethrin, are antagonists of the insect Rdl GABA receptor. Taylor-Wells J, et al. J Neurochem, 2015 Nov. PMID 26296809
    2. Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabiensis. Du W, et al. Insect Mol Biol, 2005 Apr. PMID 15796751
    3. Species specific RNA A-to-I editing of mosquito RDL modulates GABA potency and influences agonistic, potentiating and antagonistic actions of ivermectin. Taylor-Wells J, et al. Insect Biochem Mol Biol, 2018 Feb. PMID 29223796
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA A-to-I editing alters the gene products of Rdl in three mosquito disease vectors, recoding five amino acid residues in RDL of Aedes aegypti and six residues in RDLs of Anopheles gambiae and Culex pipiens, which is the highest extent of editing in RDL observed to date. Analysis of An. gambiae Rdl cDNA sequences identified 24 editing isoforms demonstrating a considerable increase in gene product diversity.
      Title: Species specific RNA A-to-I editing of mosquito RDL modulates GABA potency and influences agonistic, potentiating and antagonistic actions of ivermectin.
    2. Mutations in the Rdl locus (coding for a gamma-aminobutyric acid (GABA) receptor subunit) confer dieldrin resistance to Anopheles gambiae.
      Title: Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabiensis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GABA-A receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neurotransmitter receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gamma-aminobutyric acid receptor subunit beta
    Names
    GABA-gated chloride channel subunit
    RDL bd

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_943734735.2-RS_2023_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference idAnoGambNW_F1_1 Primary Assembly

    Genomic

    1. NC_064601.1 Reference idAnoGambNW_F1_1 Primary Assembly

      Range
      94255896..94341446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_316071.5 → XP_316071.4  gamma-aminobutyric acid receptor subunit beta isoform X3

      See identical proteins and their annotated locations for XP_316071.4

      UniProtKB/TrEMBL
      Q7PII2
      Conserved Domains (2) summary
      TIGR00860
      Location:56 → 537
      LIC; Cation transporter family protein
      cd19008
      Location:78 → 261
      LGIC_ECD_GABAR_RDL-like; gamma-aminobutyric acid receptor subunit beta-like extracellular domain in protostomia, such as RDL (resistant to dieldrin)

    2. XM_001688723.2 → XP_001688775.1  gamma-aminobutyric acid receptor subunit beta isoform X1

      See identical proteins and their annotated locations for XP_001688775.1

      UniProtKB/TrEMBL
      A7UU05
      Conserved Domains (2) summary
      TIGR00860
      Location:56 → 537
      LIC; Cation transporter family protein
      cd19008
      Location:78 → 261
      LGIC_ECD_GABAR_RDL-like; gamma-aminobutyric acid receptor subunit beta-like extracellular domain in protostomia, such as RDL (resistant to dieldrin)

    3. XM_316070.5 → XP_316070.4  gamma-aminobutyric acid receptor subunit beta isoform X4

      See identical proteins and their annotated locations for XP_316070.4

      UniProtKB/TrEMBL
      Q7PII3
      Conserved Domains (3) summary
      TIGR00860
      Location:56 → 537
      LIC; Cation transporter family protein
      pfam02931
      Location:55 → 258
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:269 → 534
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    4. XM_061647962.1 → XP_061503946.1  gamma-aminobutyric acid receptor subunit beta isoform X2

      UniProtKB/TrEMBL
      A0A1I9VT68

    5. XM_061647966.1 → XP_061503950.1  gamma-aminobutyric acid receptor subunit beta isoform X5

    6. XM_061647967.1 → XP_061503951.1  gamma-aminobutyric acid receptor subunit beta isoform X6

    7. XM_061647965.1 → XP_061503949.1  gamma-aminobutyric acid receptor subunit beta isoform X1

      UniProtKB/TrEMBL
      A7UU05

    8. XM_061647964.1 → XP_061503948.1  gamma-aminobutyric acid receptor subunit beta isoform X1

      UniProtKB/TrEMBL
      A7UU05

    9. XM_061647963.1 → XP_061503947.1  gamma-aminobutyric acid receptor subunit beta isoform X1

      UniProtKB/TrEMBL
      A7UU05
    Nucleotide Protein Strain
    Heading Accession and Version

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