Eif3c eukaryotic translation initiation factor 3, subunit C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif3cprovided by MGI
Official Full Name: eukaryotic translation initiation factor 3, subunit Cprovided by MGI
Primary source: MGI:MGI:1926966
See related: Ensembl:ENSMUSG00000030738 AllianceGenome:MGI:1926966
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Xs; Xsl; 110kDa; Eif3s8; NipilA3; NIPIL(A3); 3230401O13Rik
Summary: Enables translation initiation factor activity. Involved in translational initiation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is expressed in several structures, including central nervous system and retina. Orthologous to several human genes including EIF3C (eukaryotic translation initiation factor 3 subunit C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 75.2), placenta adult (RPKM 74.3) and 28 other tissues See more
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Genomic context

Location:: 7 69.14 cM; 7 F3

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (126146083..126165538, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (126546911..126566366, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.
Title: EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1)
Spontaneous (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
contributes_to translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to translation initiation factor activity	ISO Inferred from Sequence Orthology more info
enables translation initiation factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in formation of cytoplasmic translation initiation complex	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 3 complex	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation initiation factor 3 complex, eIF3m	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: eukaryotic translation initiation factor 3 subunit C

Names: NIPI-like protein; eIF3 p110; eukaryotic translation initiation factor 3 subunit 8; eukaryotic translation initiation factor 3, subunit 8 (110 kDa); extra-toes spotting

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146200.1 → NP_666312.1 eukaryotic translation initiation factor 3 subunit C

See identical proteins and their annotated locations for NP_666312.1

Status: PROVISIONAL

Source sequence(s)

BC024855

Consensus CDS

CCDS21832.1

UniProtKB/Swiss-Prot

Q8R1B4, Q8R3M7

Related

ENSMUSP00000032992.5, ENSMUST00000032992.7

Conserved Domains (2) summary

smart00753
Location:776 → 864

PAM; PCI/PINT associated module

pfam05470
Location:29 → 703

eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus