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    Sgpp2 sphingosine-1-phosphate phosphatase 2 [ Mus musculus (house mouse) ]

    Gene ID: 433323, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sgpp2provided by MGI
    Official Full Name
    sphingosine-1-phosphate phosphatase 2provided by MGI
    Primary source
    MGI:MGI:3589109
    See related
    Ensembl:ENSMUSG00000032908 AllianceGenome:MGI:3589109
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spp2; SPPase2
    Summary
    Enables sphingosine-1-phosphate phosphatase activity. Involved in regulation of type B pancreatic cell proliferation. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human SGPP2 (sphingosine-1-phosphate phosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 23.4), cerebellum adult (RPKM 20.7) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sgpp2 in Genome Data Viewer
    Location:
    1 C4; 1 40.23 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (78286186..78396926)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (78309549..78420289)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Pax3 upstream hypaxial enhancer Neighboring gene predicted gene, 33152 Neighboring gene predicted gene 2102 Neighboring gene STARR-seq mESC enhancer starr_01424 Neighboring gene STARR-seq mESC enhancer starr_01425 Neighboring gene predicted gene, 51634 Neighboring gene STARR-seq mESC enhancer starr_01426 Neighboring gene STARR-positive B cell enhancer ABC_E4327 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 2 pseudogene Neighboring gene phenylalanyl-tRNA synthetase, beta subunit Neighboring gene STARR-positive B cell enhancer ABC_E9179 Neighboring gene STARR-seq mESC enhancer starr_01427 Neighboring gene STARR-positive B cell enhancer ABC_E5774 Neighboring gene STARR-positive B cell enhancer ABC_E322 Neighboring gene monoacylglycerol O-acyltransferase 1 Neighboring gene predicted gene, 39665 Neighboring gene RIKEN cDNA 5730419F03 gene Neighboring gene STARR-seq mESC enhancer starr_01430 Neighboring gene STARR-seq mESC enhancer starr_01431 Neighboring gene predicted gene, 57683

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet β-Cell Endoplasmic Reticulum Stress and Proliferation. Taguchi Y, et al. J Biol Chem, 2016 Jun 3. PMID 27059959, Free PMC Article
    2. Dynamic regulation of sphingosine-1-phosphate homeostasis during development of mouse metanephric kidney. Kirby RJ, et al. Am J Physiol Renal Physiol, 2009 Mar. PMID 19073640, Free PMC Article
    3. Spatiotemporal structure of cell fate decisions in murine neural crest. Soldatov R, et al. Science, 2019 Jun 7. PMID 31171666
    4. Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development. López-Juárez A, et al. Glia, 2011 Apr. PMID 21319224, Free PMC Article
    5. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC59240

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dihydrosphingosine-1-phosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingosine-1-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingosine-1-phosphate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sphingosine-1-phosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of type B pancreatic cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingosine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sphingosine-1-phosphate phosphatase 2
    Names
    sphingosine-1-phosphatase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004173.2 → NP_001004173.1  sphingosine-1-phosphate phosphatase 2

      See identical proteins and their annotated locations for NP_001004173.1

      Status: VALIDATED

      Source sequence(s)
      AC115932, AC124989, AK081023, BY234834, BY297240, CK389092
      Consensus CDS
      CCDS15083.1
      UniProtKB/Swiss-Prot
      B2RWL5, Q810K3
      Related
      ENSMUSP00000036656.9, ENSMUST00000036172.10
      Conserved Domains (1) summary
      cd03388
      Location:39 → 188
      PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      78286186..78396926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238695.3 → XP_011236997.1  sphingosine-1-phosphate phosphatase 2 isoform X4

      Conserved Domains (1) summary
      cd03388
      Location:39 → 171
      PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...

    2. XM_030255370.2 → XP_030111230.1  sphingosine-1-phosphate phosphatase 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RWL5, Q810K3
      Conserved Domains (1) summary
      cd03388
      Location:39 → 188
      PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...

    3. XM_030255371.2 → XP_030111231.1  sphingosine-1-phosphate phosphatase 2 isoform X2

      Conserved Domains (1) summary
      cd03388
      Location:29 → 135
      PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...

    4. XM_017321596.3 → XP_017177085.1  sphingosine-1-phosphate phosphatase 2 isoform X3

      Conserved Domains (1) summary
      cd03388
      Location:1 → 105
      PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...

    RNA

    1. XR_373543.5 RNA Sequence

    2. XR_373544.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q810K3.1 GenPept UniProtKB/Swiss-Prot:Q810K3

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