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    LINC00632 long intergenic non-protein coding RNA 632 [ Homo sapiens (human) ]

    Gene ID: 286411, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC00632provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 632provided by HGNC
    Primary source
    HGNC:HGNC:27865
    See related
    Ensembl:ENSG00000203930 AllianceGenome:HGNC:27865
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARST; BMOR; ASINC; MDHDH; CDR1as; ciRS-7; CDR1-AS; CDR1NAT
    Expression
    Biased expression in brain (RPKM 3.1), fat (RPKM 0.6) and 2 other tissues See more
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    Genomic context

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    See LINC00632 in Genome Data Viewer
    Location:
    Xq27.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (140709759..140791357)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (139021766..139108724)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (139791924..139873522)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373344 Neighboring gene NANOG hESC enhancer GRCh37_chrX:139608152-139608653 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:139655621-139655814 Neighboring gene uncharacterized LOC101928833 Neighboring gene NANOG hESC enhancer GRCh37_chrX:139805503-139806004 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:139865334-139866831 Neighboring gene microRNA 320d-2 Neighboring gene SPANX family member B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LINC00632 relates to milder Th1/Th2 imbalance, attenuated nasal symptoms, and better response to therapy in allergic rhinitis patients. Shi Y, et al. Allergol Immunopathol (Madr), 2023. PMID 36916096
    2. A brain-enriched lncRNA shields cancer cells from immune-mediated killing for metastatic colonization in the brain. Liu W, et al. Proc Natl Acad Sci U S A, 2022 May 31. PMID 35617432, Free PMC Article
    3. A novel lncRNA ARST represses glioma progression by inhibiting ALDOA-mediated actin cytoskeleton integrity. Sun J, et al. J Exp Clin Cancer Res, 2021 Jun 7. PMID 34099027, Free PMC Article
    4. LINC00632 inhibits the malignant development of non-small cell lung cancer by downregulating miR-1203. Luo T, et al. J BUON, 2020 May-Jun. PMID 32862599
    5. Mesenchymal Stem Cell-Derived Exosome-Containing Linc00632 Regulates GATA Binding Protein-3 Expression in Allergic Rhinitis by Interacting with Enhancer of Zeste Homolog 2 to Inhibit T Helper Cell 2 Differentiation. Li W, et al. Int Arch Allergy Immunol, 2022. PMID 34537772

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel lncRNA ARST represses glioma progression by inhibiting ALDOA-mediated actin cytoskeleton integrity.
      Title: A novel lncRNA ARST represses glioma progression by inhibiting ALDOA-mediated actin cytoskeleton integrity.
    2. LINC00632 relates to milder Th1/Th2 imbalance, attenuated nasal symptoms, and better response to therapy in allergic rhinitis patients.
      Title: LINC00632 relates to milder Th1/Th2 imbalance, attenuated nasal symptoms, and better response to therapy in allergic rhinitis patients.
    3. A brain-enriched lncRNA shields cancer cells from immune-mediated killing for metastatic colonization in the brain.
      Title: A brain-enriched lncRNA shields cancer cells from immune-mediated killing for metastatic colonization in the brain.
    4. Mesenchymal Stem Cell-Derived Exosome-Containing Linc00632 Regulates GATA Binding Protein-3 Expression in Allergic Rhinitis by Interacting with Enhancer of Zeste Homolog 2 to Inhibit T Helper Cell 2 Differentiation.
      Title: Mesenchymal Stem Cell-Derived Exosome-Containing Linc00632 Regulates GATA Binding Protein-3 Expression in Allergic Rhinitis by Interacting with Enhancer of Zeste Homolog 2 to Inhibit T Helper Cell 2 Differentiation.
    5. LINC00632 inhibits the malignant development of non-small cell lung cancer by downregulating miR-1203.
      Title: LINC00632 inhibits the malignant development of non-small cell lung cancer by downregulating miR-1203.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • ALDOA related specific transcript
    • CDR1 antisense RNA
    • alternatively spliced into CiRS-7
    • brain metastasis oncogenic lncRNA
    • malate dehydrogenase degradation helper

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_028344.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AK054978, BQ343502, DA082671, DB307877
      Related
      ENST00000370535.8

    2. NR_028345.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and its 3' terminal exon extends past a splice site used in variant 1, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      DA128399, DA529197

    3. NR_104228.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon and contains two alternate 3' exons, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AL078639, BM811380, DA082671
      Related
      ENST00000498732.9

    4. NR_173139.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078639, AL844175
      Related
      ENST00000650128.1

    5. NR_173140.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078639, AL844175
      Related
      ENST00000649329.1

    6. NR_173141.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078639
      Related
      ENST00000625883.2

    7. NR_173142.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078639

    8. NR_173143.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078639
      Related
      ENST00000650391.2

    9. NR_173144.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078639, AL844175
      Related
      ENST00000648186.1

    10. NR_190227.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078639

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      140709759..140791357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      139021766..139108724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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