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    Rad9a RAD9 checkpoint clamp component A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100361529, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Rad9aprovided by RGD
    Official Full Name
    RAD9 checkpoint clamp component Aprovided by RGD
    Primary source
    RGD:2319938
    See related
    EnsemblRapid:ENSRNOG00000018729 AllianceGenome:RGD:2319938
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rad9
    Summary
    Predicted to enable 3'-5' exonuclease activity; SH3 domain binding activity; and enzyme binding activity. Predicted to be involved in DNA integrity checkpoint signaling; DNA repair; and cellular response to ionizing radiation. Predicted to act upstream of or within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of checkpoint clamp complex. Orthologous to human RAD9A (RAD9 checkpoint clamp component A). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 148.4), Spleen (RPKM 117.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rad9a in Genome Data Viewer
    Location:
    1q43
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210917970..210983038, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201488511..201553582, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219443347..219450574, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene carnosine synthase 1 Neighboring gene TBC1 domain family, member 10C Neighboring gene protein phosphatase 1 catalytic subunit alpha Neighboring gene cardiotrophin-like cytokine factor 1 Neighboring gene DNA polymerase delta 4, accessory subunit Neighboring gene uncharacterized LOC103691274 Neighboring gene slingshot protein phosphatase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human DNA damage checkpoint protein hRAD9 is a 3' to 5' exonuclease. Bessho T, et al. J Biol Chem, 2000 Mar 17. PMID 10713044
    2. Molecular cloning and tissue-specific expression of Mrad9, a murine orthologue of the Schizosaccharomyces pombe rad9+ checkpoint control gene. Hang H, et al. J Cell Physiol, 1998 Nov. PMID 9766521
    3. The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD. Lindsey-Boltz LA, et al. Nucleic Acids Res, 2004. PMID 15326225, Free PMC Article
    4. Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex. Volkmer E, et al. J Biol Chem, 1999 Jan 8. PMID 9872989
    5. c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage. Yoshida K, et al. Mol Cell Biol, 2002 May. PMID 11971963, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to ionizing radiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic intra-S DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of checkpoint clamp complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of checkpoint clamp complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell cycle checkpoint control protein RAD9A
    Names
    RAD9 homolog A
    rCG47324-like
    NP_001414523.1
    XP_063138223.1
    XP_063138250.1
    XP_063138293.1
    XP_063138325.1
    XP_063138360.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427594.1 → NP_001414523.1  cell cycle checkpoint control protein RAD9A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HYV6, A6HYV7, D3ZXM2
      Related
      ENSRNOP00000025317.4, ENSRNOT00000025317.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210917970..210983038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282223.1 → XP_063138293.1  cell cycle checkpoint control protein RAD9A isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZKG2, A6HYV7

    2. XM_063282180.1 → XP_063138250.1  cell cycle checkpoint control protein RAD9A isoform X2

    3. XM_063282153.1 → XP_063138223.1  cell cycle checkpoint control protein RAD9A isoform X1

    4. XM_063282290.1 → XP_063138360.1  cell cycle checkpoint control protein RAD9A isoform X5

    5. XM_063282255.1 → XP_063138325.1  cell cycle checkpoint control protein RAD9A isoform X4

    RNA

    1. XR_005499553.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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