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    Odad1 outer dynein arm docking complex subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308594, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Odad1provided by RGD
    Official Full Name
    outer dynein arm docking complex subunit 1provided by RGD
    Primary source
    RGD:1308141
    See related
    EnsemblRapid:ENSRNOG00000021109 AllianceGenome:RGD:1308141
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc114; RGD1308141
    Summary
    Predicted to be involved in cilium movement and outer dynein arm assembly. Predicted to be located in cilium. Predicted to be part of outer dynein arm and outer dynein arm docking complex. Predicted to be active in axoneme. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 20. Orthologous to human ODAD1 (outer dynein arm docking complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 22.5), Lung (RPKM 15.8) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Odad1 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105530196..105557358)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96392132..96420926)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101904042..101932999)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 143 Neighboring gene epithelial membrane protein 3 Neighboring gene ATP binding cassette subfamily C member 6 Neighboring gene Nodal modulator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Splice-site mutations in the axonemal outer dynein arm docking complex gene CCDC114 cause primary ciliary dyskinesia. Onoufriadis A, et al. Am J Hum Genet, 2013 Jan 10. PMID 23261303, Free PMC Article
    2. Exome sequencing identifies mutations in CCDC114 as a cause of primary ciliary dyskinesia. Knowles MR, et al. Am J Hum Genet, 2013 Jan 10. PMID 23261302, Free PMC Article
    3. CCDC151 mutations cause primary ciliary dyskinesia by disruption of the outer dynein arm docking complex formation. Hjeij R, et al. Am J Hum Genet, 2014 Sep 4. PMID 25192045, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium movement ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in outer dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in outer dynein arm assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of outer dynein arm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of outer dynein arm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of outer dynein arm docking complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    outer dynein arm-docking complex subunit 1
    Names
    coiled-coil domain containing 114
    coiled-coil domain-containing protein 114

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126277.2 → NP_001119749.1  outer dynein arm-docking complex subunit 1

      See identical proteins and their annotated locations for NP_001119749.1

      Status: PROVISIONAL

      Source sequence(s)
      BC160835
      UniProtKB/Swiss-Prot
      B1H228
      UniProtKB/TrEMBL
      A0A8L2QGM5
      Related
      ENSRNOP00000028662.6, ENSRNOT00000028662.7
      Conserved Domains (1) summary
      COG1196
      Location:34 → 433
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      105530196..105557358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759387.4 → XP_008757609.1  outer dynein arm-docking complex subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_008757609.1

      UniProtKB/Swiss-Prot
      B1H228
      UniProtKB/TrEMBL
      A0A8L2QGM5
      Conserved Domains (1) summary
      COG1196
      Location:34 → 433
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_039112387.2 → XP_038968315.1  outer dynein arm-docking complex subunit 1 isoform X6

      Conserved Domains (1) summary
      TIGR02168
      Location:24 → 319
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_063262177.1 → XP_063118247.1  outer dynein arm-docking complex subunit 1 isoform X1

      UniProtKB/Swiss-Prot
      B1H228
      UniProtKB/TrEMBL
      A0A8L2QGM5

    4. XM_008759389.4 → XP_008757611.1  outer dynein arm-docking complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QGM5
      Conserved Domains (1) summary
      COG1196
      Location:27 → 295
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_039112376.2 → XP_038968304.1  outer dynein arm-docking complex subunit 1 isoform X5

      UniProtKB/TrEMBL
      A6JBA3
      Conserved Domains (2) summary
      COG1196
      Location:6 → 190
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl06641
      Location:401 → 464
      Fea1; Low iron-inducible periplasmic protein

    6. XM_063262179.1 → XP_063118249.1  outer dynein arm-docking complex subunit 1 isoform X4

      UniProtKB/TrEMBL
      A6JBA3

    7. XM_039112365.2 → XP_038968293.1  outer dynein arm-docking complex subunit 1 isoform X3

      UniProtKB/TrEMBL
      A6JBA3
      Conserved Domains (2) summary
      COG1196
      Location:41 → 249
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl06641
      Location:460 → 523
      Fea1; Low iron-inducible periplasmic protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1H228.1 GenPept UniProtKB/Swiss-Prot:B1H228

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