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    Cemip2 cell migration inducing hyaluronidase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309400, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cemip2provided by RGD
    Official Full Name
    cell migration inducing hyaluronidase 2provided by RGD
    Primary source
    RGD:1307941
    See related
    EnsemblRapid:ENSRNOG00000012782 AllianceGenome:RGD:1307941
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmem2
    Summary
    Predicted to enable calcium ion binding activity and hyalurononglucosaminidase activity. Predicted to be involved in hyaluronan catabolic process. Predicted to be located in cytosol; nucleolus; and plasma membrane. Orthologous to human CEMIP2 (cell migration inducing hyaluronidase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 292.2), Lung (RPKM 142.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cemip2 in Genome Data Viewer
    Location:
    1q51
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (228756826..228834313)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (219330295..219407760)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (239397322..239474931)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348948 Neighboring gene small ribosomal subunit protein uS17-like Neighboring gene eukaryotic translation initiation factor 4A1, pseudogene 7 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene large ribosomal subunit protein uL22-like Neighboring gene transient receptor potential cation channel, subfamily M, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Potential mechanism of TMEM2/CD44 in endoplasmic reticulum stress‑induced neuronal apoptosis in a rat model of traumatic brain injury. Wu M, et al. Int J Mol Med, 2023 Dec. PMID 37888730, Free PMC Article
    2. A mammalian homolog of the zebrafish transmembrane protein 2 (TMEM2) is the long-sought-after cell-surface hyaluronidase. Yamamoto H, et al. J Biol Chem, 2017 May 5. PMID 28246172, Free PMC Article
    3. Rare inborn errors associated with chronic hepatitis B virus infection. Zhao Q, et al. Hepatology, 2012 Nov. PMID 22610944
    4. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
    5. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Potential mechanism of TMEM2/CD44 in endoplasmic reticulum stress-induced neuronal apoptosis in a rat model of traumatic brain injury.
      Title: Potential mechanism of TMEM2/CD44 in endoplasmic reticulum stress‑induced neuronal apoptosis in a rat model of traumatic brain injury.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables hyalurononglucosaminidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hyalurononglucosaminidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in hyaluronan catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inactive cell surface hyaluronidase CEMIP2
    Names
    cell surface hyaluronidase
    transmembrane protein 2
    NP_001101066.1
    XP_006231225.1
    XP_006231228.1
    XP_008758520.1
    XP_008758521.1
    XP_038936097.1
    XP_038936113.1
    XP_063120774.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107596.1 → NP_001101066.1  inactive cell surface hyaluronidase CEMIP2

      See identical proteins and their annotated locations for NP_001101066.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A6I0M8, D3ZZ19
      Related
      ENSRNOP00000063313.1, ENSRNOT00000067384.3
      Conserved Domains (3) summary
      cd13938
      Location:220 → 387
      PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
      pfam10162
      Location:123 → 244
      G8; G8 domain
      pfam15711
      Location:1232 → 1321
      ILEI; Interleukin-like EMT inducer

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      228756826..228834313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231166.5 → XP_006231228.1  inactive cell surface hyaluronidase CEMIP2 isoform X1

      See identical proteins and their annotated locations for XP_006231228.1

      UniProtKB/TrEMBL
      A0A0G2JZA7
      Conserved Domains (3) summary
      cd13938
      Location:220 → 387
      PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
      pfam10162
      Location:122 → 244
      G8; G8 domain
      pfam15711
      Location:1244 → 1328
      ILEI; Interleukin-like EMT inducer

    2. XM_008760299.4 → XP_008758521.1  inactive cell surface hyaluronidase CEMIP2 isoform X1

      See identical proteins and their annotated locations for XP_008758521.1

      UniProtKB/TrEMBL
      A0A0G2JZA7
      Conserved Domains (3) summary
      cd13938
      Location:220 → 387
      PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
      pfam10162
      Location:122 → 244
      G8; G8 domain
      pfam15711
      Location:1244 → 1328
      ILEI; Interleukin-like EMT inducer

    3. XM_006231163.4 → XP_006231225.1  inactive cell surface hyaluronidase CEMIP2 isoform X1

      See identical proteins and their annotated locations for XP_006231225.1

      UniProtKB/TrEMBL
      A0A0G2JZA7
      Related
      ENSRNOP00000070973.1, ENSRNOT00000087386.3
      Conserved Domains (3) summary
      cd13938
      Location:220 → 387
      PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
      pfam10162
      Location:122 → 244
      G8; G8 domain
      pfam15711
      Location:1244 → 1328
      ILEI; Interleukin-like EMT inducer

    4. XM_039080169.2 → XP_038936097.1  inactive cell surface hyaluronidase CEMIP2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZA7
      Conserved Domains (3) summary
      cd13938
      Location:220 → 387
      PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
      pfam10162
      Location:122 → 244
      G8; G8 domain
      pfam15711
      Location:1244 → 1328
      ILEI; Interleukin-like EMT inducer

    5. XM_063264704.1 → XP_063120774.1  inactive cell surface hyaluronidase CEMIP2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZA7

    6. XM_008760298.3 → XP_008758520.1  inactive cell surface hyaluronidase CEMIP2 isoform X1

      See identical proteins and their annotated locations for XP_008758520.1

      UniProtKB/TrEMBL
      A0A0G2JZA7
      Conserved Domains (3) summary
      cd13938
      Location:220 → 387
      PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
      pfam10162
      Location:122 → 244
      G8; G8 domain
      pfam15711
      Location:1244 → 1328
      ILEI; Interleukin-like EMT inducer

    7. XM_039080185.2 → XP_038936113.1  inactive cell surface hyaluronidase CEMIP2 isoform X2

      Conserved Domains (3) summary
      cd13938
      Location:81 → 248
      PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
      pfam10162
      Location:5 → 105
      G8; G8 domain
      pfam15711
      Location:1105 → 1189
      ILEI; Interleukin-like EMT inducer
    Nucleotide Protein Strain
    Heading Accession and Version

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