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    Snx32 sorting nexin 32 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361708, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx32provided by RGD
    Official Full Name
    sorting nexin 32provided by RGD
    Primary source
    RGD:1560591
    See related
    EnsemblRapid:ENSRNOG00000026527 AllianceGenome:RGD:1560591
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Snx6b; RGD1560591
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be located in cytosol. Predicted to be active in endosome. Orthologous to human SNX32 (sorting nexin 32). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 256.0), Brain (RPKM 226.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snx32 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212231716..212248127, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202801090..202818731, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220873782..220890804, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MUS81 structure-specific endonuclease subunit Neighboring gene cofilin 1 Neighboring gene MAGE family member B10 Neighboring gene ribosomal protein L37, pseudogene 2 Neighboring gene ovo like transcriptional repressor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin 32; sorting nexin-32
    Names
    sorting nexin 6B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432327.1 → NP_001419256.1  sorting nexin 32 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6ARA2, F1LU14

    2. NM_001432328.1 → NP_001419257.1  sorting nexin 32 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6ARA2

    3. NM_001432329.1 → NP_001419258.1  sorting nexin 32 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      212231716..212248127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279880.1 → XP_063135950.1  sorting nexin-32 isoform X4

    2. XM_006230941.5 → XP_006231003.1  sorting nexin-32 isoform X2

      See identical proteins and their annotated locations for XP_006231003.1

      UniProtKB/TrEMBL
      A0A8I6ARA2
      Conserved Domains (2) summary
      cd06892
      Location:34 → 163
      PX_SNX5_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 5 and 6
      cd07621
      Location:180 → 356
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6

    3. XM_039094864.2 → XP_038950792.1  sorting nexin-32 isoform X7

      Conserved Domains (2) summary
      cd06892
      Location:34 → 171
      PX_SNX5_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 5 and 6
      cl12013
      Location:188 → 270
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. XM_039094858.2 → XP_038950786.2  sorting nexin-32 isoform X6

    5. XM_341993.10 → XP_341994.5  sorting nexin-32 isoform X3

      Related
      ENSRNOP00000031258.7, ENSRNOT00000036745.8
      Conserved Domains (2) summary
      cd07621
      Location:188 → 408
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
      cl02563
      Location:34 → 171
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    6. XM_006230940.5 → XP_006231002.1  sorting nexin-32 isoform X1

      See identical proteins and their annotated locations for XP_006231002.1

      UniProtKB/TrEMBL
      A0A8I6ARA2
      Conserved Domains (2) summary
      cd06892
      Location:34 → 171
      PX_SNX5_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 5 and 6
      cd07621
      Location:188 → 364
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6

    7. XM_017590289.3 → XP_017445778.1  sorting nexin-32 isoform X5

      Conserved Domains (2) summary
      cd07621
      Location:62 → 238
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
      cl02563
      Location:1 → 45
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    8. XM_039094849.2 → XP_038950777.1  sorting nexin-32 isoform X5

      Conserved Domains (2) summary
      cd07621
      Location:62 → 238
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
      cl02563
      Location:1 → 45
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    9. XM_008760202.4 → XP_008758424.1  sorting nexin-32 isoform X5

      See identical proteins and their annotated locations for XP_008758424.1

      Conserved Domains (2) summary
      cd07621
      Location:62 → 238
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
      cl02563
      Location:1 → 45
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    10. XM_039094845.2 → XP_038950773.1  sorting nexin-32 isoform X5

      Conserved Domains (2) summary
      cd07621
      Location:62 → 238
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
      cl02563
      Location:1 → 45
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    11. XM_039094843.2 → XP_038950771.1  sorting nexin-32 isoform X5

      Conserved Domains (2) summary
      cd07621
      Location:62 → 238
      BAR_SNX5_6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 5 and 6
      cl02563
      Location:1 → 45
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    Nucleotide Protein Strain
    Heading Accession and Version

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