Srr serine racemase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Srrprovided by RGD
Official Full Name: serine racemaseprovided by RGD
Primary source: RGD:735094
See related: EnsemblRapid:ENSRNOG00000002991 AllianceGenome:RGD:735094
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including heterocyclic compound binding activity; magnesium ion binding activity; and protein homodimerization activity. Involved in alpha-amino acid metabolic process; response to organic cyclic compound; and response to xenobiotic stimulus. Located in apical part of cell. Orthologous to human SRR (serine racemase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 246.5), Kidney (RPKM 145.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (60267936..60285094, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (59769563..59786688, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (61756138..61772327, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serine racemase expression profile in the prefrontal cortex and hippocampal subregions during aging in male and female rats.
Title: Serine racemase expression profile in the prefrontal cortex and hippocampal subregions during aging in male and female rats.
Study to demonstrate that serine racemase inhibitor alleviates neuronal ischemic injury. Serine racemase inhibition acts on the neurovascular unit as a neuroprotectant and ameliorant of reductions in regional cerebral blood flow.
Title: Serine racemase inhibition induces nitric oxide-mediated neurovascular protection during cerebral ischemia.
results indicate that SRR indeed acts as a d-Asp biosynthetic enzyme in some organs and/or tissues, and also provide evidences that there should be some additional enzyme for d-Asp synthesis in mammals.
Title: Serine racemase is involved in d-aspartate biosynthesis.
In aging cerebellum, oxidative DNA stress was associated with reduced serine racemase expression.
Title: Reduced serine racemase expression in aging rat cerebellum is associated with oxidative DNA stress and hypermethylation in the promoter.
that nuclear translocation of SR provides a fail-safe mechanism to prevent or limit secondary NMDAR-mediated toxicity in nearby synapses.
Title: Nuclear Compartmentalization of Serine Racemase Regulates D-Serine Production: IMPLICATIONS FOR N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ACTIVATION.
In serine racemase, similarly to the related enzyme alanine racemase, the unprotonated pyridoxal-5'-phosphate -substrate intermediate is stabilized mostly due to solvation effects contributed by water molecules and active-site residues.
Title: Understanding the reaction mechanism and intermediate stabilization in mammalian serine racemase using multiscale quantum-classical simulations.
neuronal, but not astrocytic expression of serine racemase is increased at the late stage of hyposmotic challenge in vivo.
Title: Hyposmolality differentially and spatiotemporally modulates levels of glutamine synthetase and serine racemase in rat supraoptic nucleus.
serine racemase is expressed in lower esophageal sphincter
Title: D-serine modulates non-adrenergic non-cholinergic contraction of lower esophageal sphincter in rats.
The serine racemase-dependent pathway is a prime target of hippocampus-dependent cognitive deficits during aging.
Title: Reduced serine racemase expression contributes to age-related deficits in hippocampal cognitive function.
The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding
Title: The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables D-serine ammonia-lyase activity	IEA Inferred from Electronic Annotation more info
enables L-serine ammonia-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-serine ammonia-lyase activity	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables glycine binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	ISO Inferred from Sequence Orthology more info
enables serine racemase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine racemase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine racemase activity	ISO Inferred from Sequence Orthology more info
enables threonine racemase activity	IBA Inferred from Biological aspect of Ancestor more info
enables threonine racemase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in D-serine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within D-serine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in D-serine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in D-serine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in D-serine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in L-serine metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within L-serine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in L-serine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pyruvate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within serine family amino acid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine racemase

Names: D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase

NP_942052.1

EC 4.3.1.17

EC 4.3.1.18

EC 5.1.1.18

XP_008766237.1

EC 4.3.1.17

EC 4.3.1.18

EC 5.1.1.18

XP_038941942.1

EC 4.3.1.17

EC 4.3.1.18

EC 5.1.1.18

XP_063125132.1

EC 4.3.1.17

EC 4.3.1.18

EC 5.1.1.18

XP_063125133.1

EC 4.3.1.17

EC 4.3.1.18

EC 5.1.1.18

XP_063125134.1

EC 4.3.1.17

EC 4.3.1.18

EC 5.1.1.18

XP_063125135.1

EC 4.3.1.17

EC 4.3.1.18

EC 5.1.1.18

XP_063125136.1

EC 4.3.1.17

EC 4.3.1.18

EC 5.1.1.18

XP_063125137.1

EC 4.3.1.17

EC 4.3.1.18

EC 5.1.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198757.2 → NP_942052.1 serine racemase

See identical proteins and their annotated locations for NP_942052.1

Status: PROVISIONAL

Source sequence(s)

BC082014

UniProtKB/Swiss-Prot

Q76EQ0

UniProtKB/TrEMBL

A0A8L2R439, A6HGP0

Related

ENSRNOP00000050774.2, ENSRNOT00000046110.6

Conserved Domains (1) summary

cl00342
Location:5 → 322

Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

60267936..60285094 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269067.1 → XP_063125137.1 serine racemase isoform X1

UniProtKB/Swiss-Prot

Q76EQ0

UniProtKB/TrEMBL

A0A8L2R439, A6HGP0
XM_063269064.1 → XP_063125134.1 serine racemase isoform X1

UniProtKB/Swiss-Prot

Q76EQ0

UniProtKB/TrEMBL

A0A8L2R439, A6HGP0
XM_039086014.2 → XP_038941942.1 serine racemase isoform X1

UniProtKB/Swiss-Prot

Q76EQ0

UniProtKB/TrEMBL

A0A8L2R439, A6HGP0

Conserved Domains (1) summary

cl00342
Location:5 → 322

Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
XM_063269065.1 → XP_063125135.1 serine racemase isoform X1

UniProtKB/Swiss-Prot

Q76EQ0

UniProtKB/TrEMBL

A0A8L2R439, A6HGP0
XM_008768015.4 → XP_008766237.1 serine racemase isoform X1

See identical proteins and their annotated locations for XP_008766237.1

UniProtKB/Swiss-Prot

Q76EQ0

UniProtKB/TrEMBL

A0A8L2R439, A6HGP0

Conserved Domains (1) summary

cl00342
Location:5 → 322

Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
XM_063269062.1 → XP_063125132.1 serine racemase isoform X1

UniProtKB/Swiss-Prot

Q76EQ0

UniProtKB/TrEMBL

A0A8L2R439, A6HGP0
XM_063269066.1 → XP_063125136.1 serine racemase isoform X1

UniProtKB/Swiss-Prot

Q76EQ0

UniProtKB/TrEMBL

A0A8L2R439, A6HGP0
XM_063269063.1 → XP_063125133.1 serine racemase isoform X1

UniProtKB/Swiss-Prot

Q76EQ0

UniProtKB/TrEMBL

A0A8L2R439, A6HGP0