Epha6 Eph receptor A6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Epha6provided by RGD
Full Name: Eph receptor A6provided by RGD
Primary source: RGD:1304614
See related: EnsemblRapid:ENSRNOG00000029184 AllianceGenome:RGD:1304614
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ehk2; EHK-2; AABR07033882.1
Summary: Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in dendrite and plasma membrane. Orthologous to human EPHA6 (EPH receptor A6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 62.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 11q12

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (53226784..54178120)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (39757501..40708901)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (41867607..42843800)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Epha6 (e-PCR), detects polymorphism
- UniSTS:495884

AU049238 (e-PCR)
- UniSTS:145686

mMECIR525 (e-PCR), detects polymorphism
- UniSTS:541734

BF415441 (e-PCR)
- UniSTS:248898

D11Got84 (e-PCR)
- UniSTS:115523

D11Rat85 (e-PCR), detects polymorphism
- UniSTS:226431

RH144116 (e-PCR)
- UniSTS:233362

RH144183 (e-PCR)
- UniSTS:233429

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ephrin type-A receptor 6

Names: EPH homology kinase 2; tyrosine-protein kinase receptor EHK-2

NP_001406458.1

EC 2.7.10.1

XP_038944648.1

EC 2.7.10.1

XP_038944649.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419529.1 → NP_001406458.1 ephrin type-A receptor 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

P54758

UniProtKB/TrEMBL

A0A8I6A6J8

Related

ENSRNOP00000087819.1, ENSRNOT00000097751.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

53226784..54178120

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088720.2 → XP_038944648.1 ephrin type-A receptor 6 isoform X1

UniProtKB/Swiss-Prot

P54758

Conserved Domains (7) summary

cd09547
Location:918 → 981

SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors

cd00063
Location:412 → 491

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:583 → 891

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam00041
Location:290 → 384

fn3; Fibronectin type III domain

pfam07699
Location:231 → 269

Ephrin_rec_like; Putative ephrin-receptor like

pfam14575
Location:507 → 585

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:1 → 163

EphR_LBD; Ligand Binding Domain of Ephrin Receptors
XM_039088721.2 → XP_038944649.1 ephrin type-A receptor 6 isoform X2

UniProtKB/Swiss-Prot

P54758

UniProtKB/TrEMBL

F1LQK6

Related

ENSRNOP00000049409.6, ENSRNOT00000047310.7

Conserved Domains (7) summary

cd09547
Location:899 → 962

SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors

cd00063
Location:393 → 472

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05066
Location:564 → 872

PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

pfam00041
Location:271 → 365

fn3; Fibronectin type III domain

pfam07699
Location:212 → 250

Ephrin_rec_like; Putative ephrin-receptor like

pfam14575
Location:488 → 566

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl02704
Location:1 → 144

EphR_LBD; Ligand Binding Domain of Ephrin Receptors