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    Dtx3l deltex E3 ubiquitin ligase 3L [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498089, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dtx3lprovided by RGD
    Official Full Name
    deltex E3 ubiquitin ligase 3Lprovided by RGD
    Primary source
    RGD:1565144
    See related
    EnsemblRapid:ENSRNOG00000023400 AllianceGenome:RGD:1565144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565144
    Summary
    Predicted to enable several functions, including STAT family protein binding activity; histone H4K91 ubiquitin ligase activity; and protein ADP-ribosyltransferase-substrate adaptor activity. Predicted to be involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of protein localization; and protein ubiquitination. Predicted to be located in several cellular components, including early endosome; lysosome; and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human DTX3L (deltex E3 ubiquitin ligase 3L). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 270.8), Spleen (RPKM 155.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dtx3l in Genome Data Viewer
    Location:
    11q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (78320225..78329837)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (64814926..64824539)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (67758093..67767623) , (67768542..67772428)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 5B Neighboring gene karyopherin subunit alpha 1 Neighboring gene uncharacterized LOC134481077 Neighboring gene poly (ADP-ribose) polymerase family, member 9 Neighboring gene caspase 6, pseudogene 1 Neighboring gene poly (ADP-ribose) polymerase family, member 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. Juszczynski P, et al. Mol Cell Biol, 2006 Jul. PMID 16809771, Free PMC Article
    2. Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9. Yang CS, et al. Mol Cell, 2017 May 18. PMID 28525742, Free PMC Article
    3. BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. Yan Q, et al. Mol Cell, 2009 Oct 9. PMID 19818714, Free PMC Article
    4. BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8. Yan Q, et al. Mol Cell Biol, 2013 Feb. PMID 23230272, Free PMC Article
    5. The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. Holleman J, et al. Mol Biol Cell, 2014 Jun 15. PMID 24790097, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables STAT family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H4K91 ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein ADP-ribosyltransferase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair-dependent chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase DTX3L
    Names
    deltex 3 like, E3 ubiquitin ligase
    deltex 3-like
    NP_001102523.2
    XP_063126776.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109053.2 → NP_001102523.2  E3 ubiquitin-protein ligase DTX3L

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6IRE9, D3Z8X6
      Related
      ENSRNOP00000034974.5, ENSRNOT00000039215.8
      Conserved Domains (2) summary
      cd09633
      Location:618 → 748
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd16712
      Location:570 → 609
      RING-HC_DTX3L; RING finger, HC subclass, found in protein Deltex-3-like (DTX3L) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      78320225..78329837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270706.1 → XP_063126776.1  E3 ubiquitin-protein ligase DTX3L isoform X1

      UniProtKB/TrEMBL
      A6IRE9
    Nucleotide Protein Strain
    Heading Accession and Version

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