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    Hip1 huntingtin interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192154, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hip1provided by RGD
    Official Full Name
    huntingtin interacting protein 1provided by RGD
    Primary source
    RGD:620305
    See related
    EnsemblRapid:ENSRNOG00000001448 AllianceGenome:RGD:620305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables clathrin binding activity. Involved in clathrin coat assembly. Located in clathrin-coated vesicle and presynaptic membrane. Is active in glutamatergic synapse; postsynaptic membrane; and presynapse. Orthologous to human HIP1 (huntingtin interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 168.4), Lung (RPKM 147.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hip1 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (26769868..26904367)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (21133364..21267796)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (24180795..24315373)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 26 Neighboring gene ribosomal protein S13, pseudogene 4 Neighboring gene uncharacterized LOC120095918 Neighboring gene uncharacterized LOC134481279 Neighboring gene uncharacterized LOC134481281 Neighboring gene uncharacterized LOC120095917

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain. Hackam AS, et al. J Biol Chem, 2000 Dec 29. PMID 11007801
    2. The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis? Gottfried I, et al. Biochem Soc Trans, 2010 Feb. PMID 20074057
    3. Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins. Mishra SK, et al. J Biol Chem, 2001 Dec 7. PMID 11577110
    4. Partially overlapping distribution of epsin1 and HIP1 at the synapse: analysis by immunoelectron microscopy. Yao PJ, et al. J Comp Neurol, 2006 Jan 10. PMID 16320245
    5. Regulation of the proapoptotic activity of huntingtin interacting protein 1 by Dyrk1 and caspase-3 in hippocampal neuroprogenitor cells. Kang JE, et al. J Neurosci Res, 2005 Jul 1. PMID 15906374

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KIF1C and new Huntingtin-interacting protein 1 binding proteins regulate rheumatoid arthritis fibroblast-like synoviocytes' phenotypes.
      Title: KIF1C and new Huntingtin-interacting protein 1 binding proteins regulate rheumatoid arthritis fibroblast-like synoviocytes' phenotypes.
    2. HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.
      Title: HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.
    3. epsin1 is located across both sides of the synapse, whereas HIP1 displays a preference for the postsynaptic compartment; results suggest a dual role for epsin1 and huntingtin-interacting protein 1 in the synapse
      Title: Partially overlapping distribution of epsin1 and HIP1 at the synapse: analysis by immunoelectron microscopy.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AP-2 adaptor complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables clathrin light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin light chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in clathrin coat assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin coat assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of platelet-derived growth factor receptor-beta signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of platelet-derived growth factor receptor-beta signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in presynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    huntingtin-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100475.1 → NP_001093945.1  huntingtin-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001093945.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/TrEMBL
      A0A8I6GA90, A6J0C8
      Related
      ENSRNOP00000031153.6, ENSRNOT00000030497.6
      Conserved Domains (5) summary
      smart00307
      Location:807 → 1005
      ILWEQ; I/LWEQ domain
      pfam07651
      Location:37 → 308
      ANTH; ANTH domain
      pfam07926
      Location:433 → 550
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam14335
      Location:336 → 441
      DUF4391; Domain of unknown function (DUF4391)
      pfam16515
      Location:482 → 572
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    2. NM_001415756.1 → NP_001402685.1  huntingtin-interacting protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6GA90, G3V8Y8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      26769868..26904367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271032.1 → XP_063127102.1  huntingtin-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GA90, G3V8Y8
      Related
      ENSRNOP00000083048.2, ENSRNOT00000119935.2

    2. XM_063271033.1 → XP_063127103.1  huntingtin-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GA90, G3V8Y8

    3. XM_063271034.1 → XP_063127104.1  huntingtin-interacting protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AA26, A6J0C9

    4. XM_006249100.5 → XP_006249162.1  huntingtin-interacting protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AA26, A6J0C9
      Related
      ENSRNOP00000088574.1, ENSRNOT00000098638.2
      Conserved Domains (4) summary
      smart00307
      Location:781 → 979
      ILWEQ; I/LWEQ domain
      pfam07651
      Location:7 → 274
      ANTH; ANTH domain
      pfam14335
      Location:302 → 407
      DUF4391; Domain of unknown function (DUF4391)
      pfam16515
      Location:448 → 546
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    5. XM_006249099.5 → XP_006249161.1  huntingtin-interacting protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y6T0, A6J0C9
      Related
      ENSRNOP00000078035.1, ENSRNOT00000104382.2
      Conserved Domains (4) summary
      smart00307
      Location:785 → 983
      ILWEQ; I/LWEQ domain
      pfam07651
      Location:11 → 278
      ANTH; ANTH domain
      pfam14335
      Location:306 → 411
      DUF4391; Domain of unknown function (DUF4391)
      pfam16515
      Location:452 → 550
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    6. XM_017598252.3 → XP_017453741.1  huntingtin-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A6J0C9
      Related
      ENSRNOP00000100363.1, ENSRNOT00000158458.1
      Conserved Domains (4) summary
      smart00307
      Location:826 → 1024
      ILWEQ; I/LWEQ domain
      COG1196
      Location:396 → 655
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07651
      Location:52 → 317
      ANTH; ANTH domain
      pfam16515
      Location:499 → 591
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    7. XM_017598253.2 → XP_017453742.1  huntingtin-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A6J0C9
      Conserved Domains (4) summary
      smart00307
      Location:826 → 1024
      ILWEQ; I/LWEQ domain
      COG1196
      Location:396 → 655
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07651
      Location:52 → 317
      ANTH; ANTH domain
      pfam16515
      Location:499 → 591
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    8. XM_039089055.1 → XP_038944983.1  huntingtin-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A6J0C9
      Conserved Domains (4) summary
      smart00307
      Location:826 → 1024
      ILWEQ; I/LWEQ domain
      COG1196
      Location:396 → 655
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07651
      Location:52 → 317
      ANTH; ANTH domain
      pfam16515
      Location:499 → 591
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    9. XM_063271036.1 → XP_063127106.1  huntingtin-interacting protein 1 isoform X5

    10. XM_063271035.1 → XP_063127105.1  huntingtin-interacting protein 1 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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