Kmt5a lysine methyltransferase 5A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kmt5aprovided by RGD
Official Full Name: lysine methyltransferase 5Aprovided by RGD
Primary source: RGD:1587560
See related: EnsemblRapid:ENSRNOG00000064318 AllianceGenome:RGD:1587560
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Setd8; Pr-set7; RGD1305893
Summary: Predicted to enable histone H4K20 methyltransferase activity and transcription corepressor activity. Predicted to be involved in negative regulation of nucleobase-containing compound metabolic process; peptidyl-lysine monomethylation; and regulation of DNA damage response, signal transduction by p53 class mediator. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be active in nucleus and polytene chromosome. Orthologous to human KMT5A (lysine methyltransferase 5A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 143.0), Adrenal (RPKM 141.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q15

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (37800339..37823706, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (32139353..32167777, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (37558150..37581183, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lysine Methyltransferase 5A Promotes the Progression of Growth Hormone Pituitary Neuroendocrine Tumors through the Wnt/beta-Catenin Signaling Pathway.
Title: Lysine Methyltransferase 5A Promotes the Progression of Growth Hormone Pituitary Neuroendocrine Tumors through the Wnt/β-Catenin Signaling Pathway.
Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
Title: Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
Mechanism of SET8 Activates the Nrf2-KEAP1-ARE Signaling Pathway to Promote the Recovery of Motor Function after Spinal Cord Injury.
Title: Mechanism of SET8 Activates the Nrf2-KEAP1-ARE Signaling Pathway to Promote the Recovery of Motor Function after Spinal Cord Injury.
Uteroplacental Insufficiency with Hypoxia Upregulates Placental PPARgamma-KMT5A Axis in the Rat.
Title: Uteroplacental Insufficiency with Hypoxia Upregulates Placental PPARγ-KMT5A Axis in the Rat.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone H4K20 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H4K20 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K20 monomethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine monomethylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA damage response, signal transduction by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in polytene chromosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: N-lysine methyltransferase KMT5A

Names: N-lysine methyltransferase SETD8; SET domain containing (lysine methyltransferase) 8; SET domain-containing 8; histone methyltransferase Pr-set7/Set8; histone-lysine N-methyltransferase SETD8; lysine (K)-specific methyltransferase 5A

NP_001233594.2

EC 2.1.1.354

NP_001400566.1

EC 2.1.1.354

XP_006249390.1

EC 2.1.1.354

XP_006249392.1

EC 2.1.1.354

XP_017453947.1

EC 2.1.1.354

XP_038945699.1

EC 2.1.1.354

XP_038945701.1

EC 2.1.1.354

XP_063127745.1

EC 2.1.1.354

XP_063127746.1

EC 2.1.1.354

XP_063127747.1

EC 2.1.1.354

XP_063127749.1

EC 2.1.1.354

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001246665.2 → NP_001233594.2 N-lysine methyltransferase KMT5A isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A8I5ZY89, A0A8J8XFN9

Related

ENSRNOP00000080894.2, ENSRNOT00000114055.2
NM_001413637.1 → NP_001400566.1 N-lysine methyltransferase KMT5A isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A8I6A5Q1, A0A8I6GKG3

Related

ENSRNOP00000088749.1, ENSRNOT00000111843.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

37800339..37823706 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249328.4 → XP_006249390.1 N-lysine methyltransferase KMT5A isoform X3

UniProtKB/TrEMBL

A0A8J8XFN9

Related

ENSRNOP00000062763.4, ENSRNOT00000066253.4

Conserved Domains (1) summary

smart00317
Location:222 → 339

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
XM_063271679.1 → XP_063127749.1 N-lysine methyltransferase KMT5A isoform X7

UniProtKB/TrEMBL

A6J0Z8
XM_017598458.3 → XP_017453947.1 N-lysine methyltransferase KMT5A isoform X6

UniProtKB/TrEMBL

A0A8I5ZQS7, A6J0Z8

Conserved Domains (1) summary

cd10528
Location:143 → 282

SET_SETD8; SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins
XM_039089771.2 → XP_038945699.1 N-lysine methyltransferase KMT5A isoform X4

UniProtKB/TrEMBL

A0A8J8XFN9, D3ZEB9, F7J138

Conserved Domains (1) summary

cd10528
Location:197 → 336

SET_SETD8; SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins
XM_063271675.1 → XP_063127745.1 N-lysine methyltransferase KMT5A isoform X1

UniProtKB/TrEMBL

A0A8J8XFN9

Related

ENSRNOP00000092997.2, ENSRNOT00000108981.2
XM_039089773.2 → XP_038945701.1 N-lysine methyltransferase KMT5A isoform X5

UniProtKB/TrEMBL

A0A8I5ZY89, A0A8J8XFN9

Conserved Domains (1) summary

cd10528
Location:192 → 331

SET_SETD8; SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins
XM_063271677.1 → XP_063127747.1 N-lysine methyltransferase KMT5A isoform X5

UniProtKB/TrEMBL

A0A8I5ZY89, A0A8J8XFN9

Related

ENSRNOP00000095821.2, ENSRNOT00000106064.2
XM_063271676.1 → XP_063127746.1 N-lysine methyltransferase KMT5A isoform X2

UniProtKB/TrEMBL

A0A8J8XFN9

Related

ENSRNOP00000084143.2, ENSRNOT00000106166.2
XM_006249330.4 → XP_006249392.1 N-lysine methyltransferase KMT5A isoform X6

UniProtKB/TrEMBL

A0A8I5ZQS7, A6J0Z8

Conserved Domains (1) summary

cd10528
Location:143 → 282

SET_SETD8; SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins