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    Atp6v1g3 ATPase H+ transporting V1 subunit G3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289407, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Atp6v1g3provided by RGD
    Official Full Name
    ATPase H+ transporting V1 subunit G3provided by RGD
    Primary source
    RGD:1304635
    See related
    EnsemblRapid:ENSRNOG00000022480 AllianceGenome:RGD:1304635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP hydrolysis activity; ATPase binding activity; and proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in synaptic vesicle lumen acidification. Predicted to act upstream of or within proton transmembrane transport. Located in cytosol and plasma membrane. Orthologous to human ATP6V1G3 (ATPase H+ transporting V1 subunit G3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 169.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp6v1g3 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (52351787..52376784)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (49800256..49825247)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (55265794..55288651)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene terminal nucleotidyltransferase 2, pseudogene 1 Neighboring gene uncharacterized LOC102548579 Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma), pseudogene 2 Neighboring gene NIMA-related kinase 7 Neighboring gene uncharacterized LOC120096259

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. V1 and V0 domains of the human H+-ATPase are linked by an interaction between the G and a subunits. Norgett EE, et al. J Biol Chem, 2007 May 11. PMID 17360703
    2. Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits. Sun-Wada GH, et al. Gene, 2003 Jan 2. PMID 12527205
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in synaptic vesicle lumen acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V1 domain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase subunit G 3
    Names
    ATPase, H+ transporting, V1 subunit G
    ATPase, H+ transporting, lysosomal V1 subunit G3
    NP_001099461.1
    XP_017454249.1
    XP_017454250.1
    XP_063128271.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105991.2 → NP_001099461.1  V-type proton ATPase subunit G 3

      See identical proteins and their annotated locations for NP_001099461.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6ICK6
      Conserved Domains (1) summary
      pfam03179
      Location:3 → 107
      V-ATPase_G; Vacuolar (H+)-ATPase G subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      52351787..52376784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598760.3 → XP_017454249.1  V-type proton ATPase subunit G 3 isoform X1

      Conserved Domains (1) summary
      pfam03179
      Location:40 → 156
      V-ATPase_G; Vacuolar (H+)-ATPase G subunit

    2. XM_017598761.3 → XP_017454250.1  V-type proton ATPase subunit G 3 isoform X2

      UniProtKB/TrEMBL
      D3ZTZ4
      Related
      ENSRNOP00000032126.5, ENSRNOT00000029679.6

    3. XM_063272201.1 → XP_063128271.1  V-type proton ATPase subunit G 3 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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