Mdm4 MDM4 regulator of p53 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mdm4provided by RGD
Official Full Name: MDM4 regulator of p53provided by RGD
Primary source: RGD:1309306
See related: EnsemblRapid:ENSRNOG00000009696 AllianceGenome:RGD:1309306
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable enzyme binding activity and ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of macromolecule metabolic process; and protein stabilization. Predicted to act upstream of or within heart development; positive regulation of cell population proliferation; and regulation of heart rate. Predicted to be located in nucleoplasm. Predicted to be part of transcription repressor complex. Orthologous to human MDM4 (MDM4 regulator of p53). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 439.4), Spleen (RPKM 316.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (46922236..47068241, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (44432596..44516165, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (49786776..49828780, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within atrial septum development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within atrioventricular valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocardial cushion morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart valve development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of biological quality	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of heart rate	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular septum development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription repressor complex	IEA Inferred from Electronic Annotation more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein Mdm4

Names: MDM4, p53 regulator; Mdm4 p53 binding protein homolog; double minute 4 homolog; double minute 4 protein; mdm2-like p53-binding protein; p53-binding protein Mdm4; protein Mdmx; transformed mouse 3T3 cell double minute 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012026.1 → NP_001012026.1 protein Mdm4

See identical proteins and their annotated locations for NP_001012026.1

Status: PROVISIONAL

Source sequence(s)

BC083647

UniProtKB/Swiss-Prot

Q5XIN1

UniProtKB/TrEMBL

A6IC66

Conserved Domains (3) summary

cd16784
Location:432 → 490

mRING-HC-C2H2C4_MDM4; Modified RING finger, HC subclass (C2H2C4-type), found in protein MDM4 and similar proteins

cd17673
Location:30 → 108

MDM4; p53-binding domain found in MDM4 and similar proteins

pfam00641
Location:300 → 329

zf-RanBP; Zn-finger in Ran binding protein and others

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

46922236..47068241 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272291.1 → XP_063128361.1 protein Mdm4 isoform X11
XM_039090702.2 → XP_038946630.1 protein Mdm4 isoform X2

UniProtKB/TrEMBL

A6IC66

Conserved Domains (3) summary

cd16784
Location:431 → 489

mRING-HC-C2H2C4_MDM4; Modified RING finger, HC subclass (C2H2C4-type), found in protein MDM4 and similar proteins

cd17673
Location:29 → 107

MDM4; p53-binding domain found in MDM4 and similar proteins

pfam00641
Location:299 → 328

zf-RanBP; Zn-finger in Ran binding protein and others
XM_039090700.2 → XP_038946628.1 protein Mdm4 isoform X1

UniProtKB/TrEMBL

A0A8L2Q5T6, A6IC66

Conserved Domains (3) summary

cd16784
Location:432 → 490

mRING-HC-C2H2C4_MDM4; Modified RING finger, HC subclass (C2H2C4-type), found in protein MDM4 and similar proteins

cd17673
Location:30 → 108

MDM4; p53-binding domain found in MDM4 and similar proteins

pfam00641
Location:300 → 329

zf-RanBP; Zn-finger in Ran binding protein and others
XM_063272288.1 → XP_063128358.1 protein Mdm4 isoform X6

UniProtKB/TrEMBL

A6IC66
XM_006249779.5 → XP_006249841.2 protein Mdm4 isoform X4

UniProtKB/TrEMBL

A6IC66

Conserved Domains (3) summary

cd16784
Location:382 → 440

mRING-HC-C2H2C4_MDM4; Modified RING finger, HC subclass (C2H2C4-type), found in protein MDM4 and similar proteins

cd17673
Location:29 → 107

MDM4; p53-binding domain found in MDM4 and similar proteins

pfam00641
Location:250 → 279

zf-RanBP; Zn-finger in Ran binding protein and others
XM_063272289.1 → XP_063128359.1 protein Mdm4 isoform X8

UniProtKB/TrEMBL

A0A8I5ZK52

Related

ENSRNOP00000076729.1, ENSRNOT00000116113.2
XM_006249777.5 → XP_006249839.2 protein Mdm4 isoform X2

UniProtKB/TrEMBL

A6IC66

Related

ENSRNOP00000012984.7, ENSRNOT00000012984.7

Conserved Domains (3) summary

cd16784
Location:431 → 489

mRING-HC-C2H2C4_MDM4; Modified RING finger, HC subclass (C2H2C4-type), found in protein MDM4 and similar proteins

cd17673
Location:29 → 107

MDM4; p53-binding domain found in MDM4 and similar proteins

pfam00641
Location:299 → 328

zf-RanBP; Zn-finger in Ran binding protein and others
XM_039090703.2 → XP_038946631.1 protein Mdm4 isoform X5

UniProtKB/TrEMBL

A6IC66

Conserved Domains (3) summary

cd16784
Location:356 → 414

mRING-HC-C2H2C4_MDM4; Modified RING finger, HC subclass (C2H2C4-type), found in protein MDM4 and similar proteins

cd17673
Location:30 → 108

MDM4; p53-binding domain found in MDM4 and similar proteins

pfam00641
Location:226 → 253

zf-RanBP; Zn-finger in Ran binding protein and others
XM_006249778.5 → XP_006249840.2 protein Mdm4 isoform X3

UniProtKB/TrEMBL

A0A8I6A2G0, A6IC66

Related

ENSRNOP00000084671.1, ENSRNOT00000112527.2

Conserved Domains (3) summary

cd16784
Location:383 → 441

mRING-HC-C2H2C4_MDM4; Modified RING finger, HC subclass (C2H2C4-type), found in protein MDM4 and similar proteins

cd17673
Location:30 → 108

MDM4; p53-binding domain found in MDM4 and similar proteins

pfam00641
Location:251 → 280

zf-RanBP; Zn-finger in Ran binding protein and others
XM_039090705.2 → XP_038946633.1 protein Mdm4 isoform X7

UniProtKB/TrEMBL

A0A8I5ZK52

Conserved Domains (1) summary

cd17673
Location:30 → 108

MDM4; p53-binding domain found in MDM4 and similar proteins
XM_039090706.2 → XP_038946634.1 protein Mdm4 isoform X9

Conserved Domains (2) summary

cd16784
Location:225 → 283

mRING-HC-C2H2C4_MDM4; Modified RING finger, HC subclass (C2H2C4-type), found in protein MDM4 and similar proteins

pfam00641
Location:93 → 122

zf-RanBP; Zn-finger in Ran binding protein and others
XM_039090708.2 → XP_038946636.1 protein Mdm4 isoform X10

Conserved Domains (1) summary

cd17673
Location:30 → 108

MDM4; p53-binding domain found in MDM4 and similar proteins
XM_063272292.1 → XP_063128362.1 protein Mdm4 isoform X12
XM_063272293.1 → XP_063128363.1 protein Mdm4 isoform X13