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    Antxr2 ANTXR cell adhesion molecule 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305633, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Antxr2provided by RGD
    Official Full Name
    ANTXR cell adhesion molecule 2provided by RGD
    Primary source
    RGD:1561294
    See related
    EnsemblRapid:ENSRNOG00000000081 AllianceGenome:RGD:1561294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metal ion binding activity and signaling receptor activity. Predicted to act upstream of or within collagen fibril organization; single fertilization; and uterus development. Predicted to be located in external side of plasma membrane. Used to study anthrax disease. Human ortholog(s) of this gene implicated in fibroma and hyaline fibromatosis syndrome. Orthologous to human ANTXR2 (ANTXR cell adhesion molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 286.4), Heart (RPKM 233.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Antxr2 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (11845774..11986166)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (11541718..11682110)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (13191716..13331286)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 5 Neighboring gene PR/SET domain 8 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120096509

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ANTXR2 Knock-Out Does Not Result in the Development of Hypertension in Rats. Liu X, et al. Am J Hypertens, 2017 Feb. PMID 28077422
    2. Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. Scobie HM, et al. PLoS Pathog, 2006 Oct. PMID 17054395, Free PMC Article
    3. PCGEM1 promotes cell proliferation and migration in endometriosis by targeting miR-124-3p-mediated ANTXR2 expression. Liu Y, et al. BMC Womens Health, 2023 Mar 13. PMID 36915057, Free PMC Article
    4. Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Hanks S, et al. Am J Hum Genet, 2003 Oct. PMID 14508707, Free PMC Article
    5. Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo. Liu S, et al. Proc Natl Acad Sci U S A, 2009 Jul 28. PMID 19617532, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PCGEM1 promotes cell proliferation and migration in endometriosis by targeting miR-124-3p-mediated ANTXR2 expression.
      Title: PCGEM1 promotes cell proliferation and migration in endometriosis by targeting miR-124-3p-mediated ANTXR2 expression.
    2. ANTXR2 might not be associated with hypertension and thus further functional analysis is warranted to identify the causal gene at this locus.
      Title: ANTXR2 Knock-Out Does Not Result in the Development of Hypertension in Rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within collagen fibril organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within uterus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    anthrax toxin receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398916.1 → NP_001385845.1  anthrax toxin receptor 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6A6B8, Q00IM8
      Related
      ENSRNOP00000087704.2, ENSRNOT00000119294.2
      Conserved Domains (3) summary
      cd01474
      Location:39 → 221
      vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...
      pfam05586
      Location:394 → 484
      Ant_C; Anthrax receptor C-terminus region
      pfam05587
      Location:216 → 315
      Anth_Ig; Anthrax receptor extracellular domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      11845774..11986166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092655.2 → XP_038948583.1  anthrax toxin receptor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A6B8
      Related
      ENSRNOP00000083517.1, ENSRNOT00000096178.2
      Conserved Domains (3) summary
      cd01474
      Location:39 → 221
      vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...
      pfam05586
      Location:394 → 475
      Ant_C; Anthrax receptor C-terminus region
      pfam05587
      Location:216 → 315
      Anth_Ig; Anthrax receptor extracellular domain

    2. XM_063273302.1 → XP_063129372.1  anthrax toxin receptor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A282, A0A8I6A6B8

    RNA

    1. XR_010057380.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials