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    Tns3 tensin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360980, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tns3provided by RGD
    Official Full Name
    tensin 3provided by RGD
    Primary source
    RGD:1564174
    See related
    EnsemblRapid:ENSRNOG00000025695 AllianceGenome:RGD:1564174
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TSN3; tensin3; RGD1564174
    Summary
    Predicted to enable guanyl-nucleotide exchange factor adaptor activity. Predicted to be involved in positive regulation of Rac protein signal transduction and positive regulation of guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within several processes, including bone resorption; negative regulation of Rho protein signal transduction; and podosome assembly. Predicted to be located in cytosol and podosome. Predicted to be active in focal adhesion. Orthologous to human TNS3 (tensin 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 240.7), Kidney (RPKM 143.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tns3 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (87387441..87619457, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (83173649..83405671, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (88673922..88907874, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352794 Neighboring gene heterogeneous nuclear ribonucleoprotein C, pseudogene 1 Neighboring gene uncharacterized LOC120096660 Neighboring gene 60S ribosomal protein L36-like Neighboring gene uncharacterized LOC134481910 Neighboring gene polycystin 1 like 1, transient receptor potential channel interacting

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inactivation of tensin3 in mice results in growth retardation and postnatal lethality. Chiang MK, et al. Dev Biol, 2005 Mar 15. PMID 15733665
    2. Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3. Cui Y, et al. Mol Cancer Res, 2004 Apr. PMID 15140944
    3. Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development. Shultz MA, et al. Am J Respir Cell Mol Biol, 2004 Mar. PMID 12947022
    4. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone resorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lung alveolus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within podosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Rac protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tensin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170459.2 → NP_001163930.1  tensin-3

      See identical proteins and their annotated locations for NP_001163930.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      C5NTX8
      Related
      ENSRNOP00000086044.1, ENSRNOT00000108654.2
      Conserved Domains (4) summary
      cd09927
      Location:1167 → 1283
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00012
      Location:72 → 186
      PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
      cd01213
      Location:1307 → 1438
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:173 → 299
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      87387441..87619457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251460.4 → XP_006251522.2  tensin-3 isoform X1

      UniProtKB/TrEMBL
      C5NTX8

    2. XM_063273400.1 → XP_063129470.1  tensin-3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZST1
      Related
      ENSRNOP00000081446.1, ENSRNOT00000115367.2

    3. XM_063273401.1 → XP_063129471.1  tensin-3 isoform X3

      Related
      ENSRNOP00000104075.1, ENSRNOT00000155100.1

    4. XM_008770335.4 → XP_008768557.1  tensin-3 isoform X2

      See identical proteins and their annotated locations for XP_008768557.1

      UniProtKB/TrEMBL
      A0A8I5ZST1, A0A8I6A0U4
      Conserved Domains (5) summary
      cd09927
      Location:1285 → 1401
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00012
      Location:190 → 304
      PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
      cd00029
      Location:39 → 85
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01213
      Location:1425 → 1556
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:291 → 417
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    5. XM_006251467.5 → XP_006251529.1  tensin-3 isoform X6

      See identical proteins and their annotated locations for XP_006251529.1

      UniProtKB/TrEMBL
      C5NTX8
      Related
      ENSRNOP00000092700.2, ENSRNOT00000095500.2
      Conserved Domains (4) summary
      cd09927
      Location:1167 → 1283
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00012
      Location:72 → 186
      PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
      cd01213
      Location:1307 → 1438
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:173 → 299
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    6. XM_063273404.1 → XP_063129474.1  tensin-3 isoform X6

    7. XM_006251462.5 → XP_006251524.1  tensin-3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A0U4, A0A8I6ADB6
      Related
      ENSRNOP00000089828.1, ENSRNOT00000110382.2
      Conserved Domains (5) summary
      cd09927
      Location:1281 → 1397
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00012
      Location:186 → 300
      PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
      cd00029
      Location:35 → 81
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01213
      Location:1421 → 1552
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:287 → 413
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    8. XM_063273403.1 → XP_063129473.1  tensin-3 isoform X6

    9. XM_008770336.4 → XP_008768558.1  tensin-3 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AHA2, A0A8I6AI66
      Related
      ENSRNOP00000092570.2, ENSRNOT00000100927.2
      Conserved Domains (4) summary
      cd09927
      Location:1199 → 1315
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      smart00012
      Location:104 → 218
      PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
      cd01213
      Location:1339 → 1470
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      pfam10409
      Location:205 → 331
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    10. XM_039092228.2 → XP_038948156.1  tensin-3 isoform X7

      Conserved Domains (2) summary
      cd09927
      Location:794 → 910
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      cd01213
      Location:934 → 1065
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

    11. XM_039092229.2 → XP_038948157.1  tensin-3 isoform X7

      Conserved Domains (2) summary
      cd09927
      Location:794 → 910
      SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
      cd01213
      Location:934 → 1065
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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