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    Btd biotinidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306262, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Btdprovided by RGD
    Official Full Name
    biotinidaseprovided by RGD
    Primary source
    RGD:1305316
    See related
    EnsemblRapid:ENSRNOG00000019656 AllianceGenome:RGD:1305316
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable biotinidase activity. Predicted to be involved in biotin metabolic process. Predicted to be located in apical part of cell; nucleolus; and perikaryon. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in biotinidase deficiency. Orthologous to human BTD (biotinidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 149.4), Liver (RPKM 114.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Btd in Genome Data Viewer
    Location:
    16p16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (6869448..6900711)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (6863068..6894345)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (7758192..7791301)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene collagen like tail subunit of asymmetric acetylcholinesterase Neighboring gene uncharacterized LOC134482450 Neighboring gene 2-hydroxyacyl-CoA lyase 1 Neighboring gene ankyrin repeat domain 28 Neighboring gene mitochondrial ribosomal protein L37, pseudogene 1 Neighboring gene uncharacterized LOC120097394 Neighboring gene uncharacterized LOC102550037

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Development and characterization of a mouse with profound biotinidase deficiency: a biotin-responsive neurocutaneous disorder. Pindolia K, et al. Mol Genet Metab, 2011 Feb. PMID 21051254, Free PMC Article
    2. Biotinidase reveals the morphogenetic sequence in cochlea and cochlear nucleus of mice. Brumwell CL, et al. Hear Res, 2005 Nov. PMID 16107307
    3. Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Palmer DJ, et al. Proteomics, 2006 Apr. PMID 16502470
    4. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109548

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables biotinidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biotin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within biotin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biotin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    biotinidase
    Names
    biotinase
    NP_001012047.1
    XP_006252671.1
    XP_006252672.1
    XP_006252674.1
    XP_006252676.1
    XP_006252677.1
    XP_006252680.1
    XP_006252681.1
    XP_006252684.1
    XP_017455568.1
    XP_038950381.1
    XP_038950382.1
    XP_038950384.1
    XP_038950385.1
    XP_038950386.1
    XP_063131418.1
    XP_063131419.1
    XP_063131420.1
    XP_063131422.1
    XP_063131423.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012047.2 → NP_001012047.1  biotinidase precursor

      See identical proteins and their annotated locations for NP_001012047.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q5FVF9
      UniProtKB/TrEMBL
      A6KFY1
      Conserved Domains (2) summary
      cd07567
      Location:36 → 339
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
      pfam19018
      Location:371 → 521
      Vanin_C; Vanin C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      6869448..6900711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275348.1 → XP_063131418.1  biotinidase isoform X1

      UniProtKB/TrEMBL
      A0A140TAI2

    2. XM_006252612.3 → XP_006252674.1  biotinidase isoform X2

      See identical proteins and their annotated locations for XP_006252674.1

      UniProtKB/Swiss-Prot
      Q5FVF9
      UniProtKB/TrEMBL
      A6KFY1
      Conserved Domains (2) summary
      cd07567
      Location:36 → 339
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
      pfam19018
      Location:371 → 521
      Vanin_C; Vanin C-terminal domain

    3. XM_039094456.2 → XP_038950384.1  biotinidase isoform X2

      UniProtKB/Swiss-Prot
      Q5FVF9
      UniProtKB/TrEMBL
      A6KFY1
      Conserved Domains (2) summary
      cd07567
      Location:36 → 339
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
      pfam19018
      Location:371 → 521
      Vanin_C; Vanin C-terminal domain

    4. XM_006252609.5 → XP_006252671.1  biotinidase isoform X1

      See identical proteins and their annotated locations for XP_006252671.1

      UniProtKB/TrEMBL
      A0A140TAI2
      Related
      ENSRNOP00000109340.1, ENSRNOT00000127104.1
      Conserved Domains (2) summary
      cd07567
      Location:50 → 353
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
      pfam19018
      Location:385 → 535
      Vanin_C; Vanin C-terminal domain

    5. XM_039094457.2 → XP_038950385.1  biotinidase isoform X2

      UniProtKB/Swiss-Prot
      Q5FVF9
      UniProtKB/TrEMBL
      A6KFY1
      Conserved Domains (2) summary
      cd07567
      Location:36 → 339
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
      pfam19018
      Location:371 → 521
      Vanin_C; Vanin C-terminal domain

    6. XM_063275350.1 → XP_063131420.1  biotinidase isoform X1

      UniProtKB/TrEMBL
      A0A140TAI2

    7. XM_039094454.2 → XP_038950382.1  biotinidase isoform X2

      UniProtKB/Swiss-Prot
      Q5FVF9
      UniProtKB/TrEMBL
      A6KFY1
      Conserved Domains (2) summary
      cd07567
      Location:36 → 339
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
      pfam19018
      Location:371 → 521
      Vanin_C; Vanin C-terminal domain

    8. XM_006252619.5 → XP_006252681.1  biotinidase isoform X1

      See identical proteins and their annotated locations for XP_006252681.1

      UniProtKB/TrEMBL
      A0A140TAI2
      Conserved Domains (2) summary
      cd07567
      Location:50 → 353
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
      pfam19018
      Location:385 → 535
      Vanin_C; Vanin C-terminal domain

    9. XM_017600079.3 → XP_017455568.1  biotinidase isoform X2

      UniProtKB/Swiss-Prot
      Q5FVF9
      UniProtKB/TrEMBL
      A6KFY1
      Conserved Domains (2) summary
      cd07567
      Location:36 → 339
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
      pfam19018
      Location:371 → 521
      Vanin_C; Vanin C-terminal domain

    10. XM_063275349.1 → XP_063131419.1  biotinidase isoform X1

      UniProtKB/TrEMBL
      A0A140TAI2

    11. XM_006252614.3 → XP_006252676.1  biotinidase isoform X2

      See identical proteins and their annotated locations for XP_006252676.1

      UniProtKB/Swiss-Prot
      Q5FVF9
      UniProtKB/TrEMBL
      A6KFY1
      Conserved Domains (2) summary
      cd07567
      Location:36 → 339
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
      pfam19018
      Location:371 → 521
      Vanin_C; Vanin C-terminal domain

    12. XM_039094453.2 → XP_038950381.1  biotinidase isoform X1

      UniProtKB/TrEMBL
      A0A140TAI2
      Conserved Domains (2) summary
      cd07567
      Location:50 → 353
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
      pfam19018
      Location:385 → 535
      Vanin_C; Vanin C-terminal domain

    13. XM_006252622.5 → XP_006252684.1  biotinidase isoform X2

      See identical proteins and their annotated locations for XP_006252684.1

      UniProtKB/Swiss-Prot
      Q5FVF9
      UniProtKB/TrEMBL
      A6KFY1
      Conserved Domains (2) summary
      cd07567
      Location:36 → 339
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
      pfam19018
      Location:371 → 521
      Vanin_C; Vanin C-terminal domain

    14. XM_006252610.4 → XP_006252672.1  biotinidase isoform X1

      See identical proteins and their annotated locations for XP_006252672.1

      UniProtKB/TrEMBL
      A0A140TAI2
      Conserved Domains (2) summary
      cd07567
      Location:50 → 353
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
      pfam19018
      Location:385 → 535
      Vanin_C; Vanin C-terminal domain

    15. XM_006252618.4 → XP_006252680.1  biotinidase isoform X2

      See identical proteins and their annotated locations for XP_006252680.1

      UniProtKB/Swiss-Prot
      Q5FVF9
      UniProtKB/TrEMBL
      A6KFY1
      Related
      ENSRNOP00000057779.5, ENSRNOT00000061063.6
      Conserved Domains (2) summary
      cd07567
      Location:36 → 339
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
      pfam19018
      Location:371 → 521
      Vanin_C; Vanin C-terminal domain

    16. XM_006252615.4 → XP_006252677.1  biotinidase isoform X2

      See identical proteins and their annotated locations for XP_006252677.1

      UniProtKB/Swiss-Prot
      Q5FVF9
      UniProtKB/TrEMBL
      A6KFY1
      Conserved Domains (2) summary
      cd07567
      Location:36 → 339
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
      pfam19018
      Location:371 → 521
      Vanin_C; Vanin C-terminal domain

    17. XM_039094458.2 → XP_038950386.1  biotinidase isoform X4

      UniProtKB/TrEMBL
      A0A8I6ANH2, A6KFY3
      Related
      ENSRNOP00000100538.1, ENSRNOT00000126690.1
      Conserved Domains (2) summary
      cd07567
      Location:31 → 289
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
      pfam19018
      Location:321 → 471
      Vanin_C; Vanin C-terminal domain

    18. XM_063275352.1 → XP_063131422.1  biotinidase isoform X2

      UniProtKB/Swiss-Prot
      Q5FVF9
      UniProtKB/TrEMBL
      A6KFY1
      Related
      ENSRNOP00000102845.1, ENSRNOT00000128281.1

    19. XM_063275353.1 → XP_063131423.1  biotinidase isoform X3

      UniProtKB/TrEMBL
      A6KFY3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVF9.1 GenPept UniProtKB/Swiss-Prot:Q5FVF9

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