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    Tenm3 teneurin transmembrane protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306451, updated on 9-Dec-2024

    Summary

    Symbol
    Tenm3provided by RGD
    Full Name
    teneurin transmembrane protein 3provided by RGD
    Primary source
    RGD:1306641
    See related
    EnsemblRapid:ENSRNOG00000012802 AllianceGenome:RGD:1306641
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Odz3
    Summary
    Predicted to enable cell adhesion molecule binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; regulation of homophilic cell adhesion; and synaptic membrane adhesion. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse; neuron projection; and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human TENM3 (teneurin transmembrane protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 118.7), Uterus (RPKM 100.3) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tenm3 in Genome Data Viewer
    Location:
    16q11
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (47984732..50711352)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (41251909..43978594)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (46422676..46929023)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene mitochondrial import receptor subunit TOM20 homolog pseudogene Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene Neighboring gene large ribosomal subunit protein uL16-like Neighboring gene uncharacterized LOC120097405 Neighboring gene U11 spliceosomal RNA Neighboring gene large ribosomal subunit protein mL48-like Neighboring gene uncharacterized LOC134482499 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134482498 Neighboring gene uncharacterized protein DDB_G0271670-like Neighboring gene uncharacterized LOC102552563 Neighboring gene uncharacterized LOC134482500 Neighboring gene macrophage migration inhibitory factor, pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in camera-type eye morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in regulation of homophilic cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of homophilic cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic membrane adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    teneurin-3
    Names
    odd Oz/ten-m homolog 3
    odz, odd Oz/ten-m homolog 3
    odz, odd Oz/ten-m homolog 3-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001169133.2NP_001162604.1  teneurin-3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6ABL2, A6JPJ6
      Related
      ENSRNOP00000091422.1, ENSRNOT00000105413.2
      Conserved Domains (9) summary
      COG3209
      Location:19182429
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11831222
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:18381878
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:23332407
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:11541513
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:16301661
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11307
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26302707
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:463814
      exchanger_TraA; outer membrane exchange protein TraA

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      47984732..50711352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275416.1XP_063131486.1  teneurin-3 isoform X1

      UniProtKB/TrEMBL
      A6JPJ6
    2. XM_039094506.2XP_038950434.1  teneurin-3 isoform X1

      UniProtKB/TrEMBL
      A6JPJ6
      Conserved Domains (9) summary
      COG3209
      Location:19252436
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11901229
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:18451885
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:23402414
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:11611520
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:16371668
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11307
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26372714
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:463821
      exchanger_TraA; outer membrane exchange protein TraA
    3. XM_039094513.2XP_038950441.1  teneurin-3 isoform X5

      UniProtKB/TrEMBL
      A6JPJ6
      Conserved Domains (9) summary
      COG3209
      Location:19182429
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11901225
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:18381878
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:23332407
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:11611513
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:16301661
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11307
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26302707
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:463821
      exchanger_TraA; outer membrane exchange protein TraA
    4. XM_039094510.2XP_038950438.1  teneurin-3 isoform X2

      UniProtKB/TrEMBL
      A6JPJ6
      Related
      ENSRNOP00000111639.1, ENSRNOT00000140066.1
      Conserved Domains (9) summary
      COG3209
      Location:19242435
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11891228
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:18441884
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:23392413
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:11601519
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:16361667
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11307
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26362713
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:463820
      exchanger_TraA; outer membrane exchange protein TraA
    5. XM_039094512.2XP_038950440.1  teneurin-3 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ABL2, A6JPJ6
      Conserved Domains (9) summary
      COG3209
      Location:19182429
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11831222
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:18381878
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:23332407
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:11541513
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:16301661
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11307
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26302707
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:463814
      exchanger_TraA; outer membrane exchange protein TraA
    6. XM_039094511.2XP_038950439.1  teneurin-3 isoform X3

      UniProtKB/TrEMBL
      A6JPJ6
      Conserved Domains (9) summary
      COG3209
      Location:19242435
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11891228
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:18441884
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:23392413
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:11601519
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:16361667
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11307
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26362713
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:463806
      exchanger_TraA; outer membrane exchange protein TraA
    7. XM_039094507.2XP_038950435.1  teneurin-3 isoform X1

      UniProtKB/TrEMBL
      A6JPJ6
      Conserved Domains (9) summary
      COG3209
      Location:19252436
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11901229
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:18451885
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:23402414
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:11611520
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:16371668
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11307
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26372714
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:463821
      exchanger_TraA; outer membrane exchange protein TraA
    8. XM_039094514.2XP_038950442.1  teneurin-3 isoform X6

      UniProtKB/TrEMBL
      A6JPJ6
      Related
      ENSRNOP00000109669.1, ENSRNOT00000137496.1
      Conserved Domains (9) summary
      COG3209
      Location:19092420
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11741213
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:18291869
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:23242398
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:11451504
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:16211652
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11307
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26212698
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:463791
      exchanger_TraA; outer membrane exchange protein TraA
    9. XM_039094515.2XP_038950443.1  teneurin-3 isoform X7

      UniProtKB/TrEMBL
      A0A8I5Y4Y3, A6JPJ6
      Related
      ENSRNOP00000076753.1, ENSRNOT00000094358.2
      Conserved Domains (9) summary
      COG3209
      Location:19022413
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11741209
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:18221862
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:23172391
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:11451497
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:16141645
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11307
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26142691
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:463791
      exchanger_TraA; outer membrane exchange protein TraA
    10. XM_039094516.2XP_038950444.1  teneurin-3 isoform X8

      UniProtKB/TrEMBL
      A6JPJ6
      Conserved Domains (9) summary
      COG3209
      Location:18322343
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:10971136
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:17521792
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:22472321
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:10681427
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:15441575
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11214
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:25442621
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:370728
      exchanger_TraA; outer membrane exchange protein TraA
    11. XM_063275418.1XP_063131488.1  teneurin-3 isoform X9

      UniProtKB/TrEMBL
      A6JPJ6
    12. XM_063275419.1XP_063131489.1  teneurin-3 isoform X10

      UniProtKB/TrEMBL
      A6JPJ6, F1LV44
      Related
      ENSRNOP00000017625.7, ENSRNOT00000017624.8
    13. XM_039094508.2XP_038950436.1  teneurin-3 isoform X1

      UniProtKB/TrEMBL
      A6JPJ6
      Conserved Domains (9) summary
      COG3209
      Location:19252436
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11901229
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:18451885
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:23402414
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:11611520
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:16371668
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11307
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26372714
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:463821
      exchanger_TraA; outer membrane exchange protein TraA
    14. XM_063275417.1XP_063131487.1  teneurin-3 isoform X1

      UniProtKB/TrEMBL
      A6JPJ6
    15. XM_039094509.2XP_038950437.1  teneurin-3 isoform X1

      UniProtKB/TrEMBL
      A6JPJ6
      Conserved Domains (9) summary
      COG3209
      Location:19252436
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11901229
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:18451885
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:23402414
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:11611520
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:16371668
      RHS_repeat; RHS Repeat
      pfam06484
      Location:11307
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26372714
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:463821
      exchanger_TraA; outer membrane exchange protein TraA
    16. XM_039094517.2XP_038950445.1  teneurin-3 isoform X11

      UniProtKB/TrEMBL
      A6JPJ6
      Conserved Domains (9) summary
      COG3209
      Location:16542165
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:919958
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:15741614
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:20692143
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:8901249
      NHL; NHL repeat unit of beta-propeller proteins
      pfam05593
      Location:13661397
      RHS_repeat; RHS Repeat
      pfam06484
      Location:136
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:23662443
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:192550
      exchanger_TraA; outer membrane exchange protein TraA
    17. XM_063275424.1XP_063131494.1  teneurin-3 isoform X11

      UniProtKB/TrEMBL
      A6JPJ6
    18. XM_063275420.1XP_063131490.1  teneurin-3 isoform X11

      UniProtKB/TrEMBL
      A6JPJ6
    19. XM_063275421.1XP_063131491.1  teneurin-3 isoform X12

      UniProtKB/TrEMBL
      A6JPJ6
    20. XM_063275422.1XP_063131492.1  teneurin-3 isoform X13

      UniProtKB/TrEMBL
      A6JPJ6
      Related
      ENSRNOP00000112352.1, ENSRNOT00000168106.1
    21. XM_063275423.1XP_063131493.1  teneurin-3 isoform X11

      UniProtKB/TrEMBL
      A6JPJ6