Nme8 NME/NM23 family member 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nme8provided by RGD
Official Full Name: NME/NM23 family member 8provided by RGD
Primary source: RGD:735069
See related: EnsemblRapid:ENSRNOG00000058285 AllianceGenome:RGD:735069
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sptrx2; Txndc3
Summary: Predicted to enable 3'-5' exonuclease activity and microtubule binding activity. Predicted to be involved in cilium assembly and flagellated sperm motility. Predicted to act upstream of or within cellular response to reactive oxygen species. Located in sperm fibrous sheath. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 6. Orthologous to human NME8 (NME/NM23 family member 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 212.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 17q11

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (49932861..50000610)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (45237022..45304948)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (47300932..47368543)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data indicate that spermatid-specific thioredoxin-2 incorporation into the sperm fibrous sheath(FS) lags well behind FS assembly, suggesting it is required during the final stages of sperm tail maturation
Title: Cloning and developmental analysis of murid spermatid-specific thioredoxin-2 (SPTRX-2), a novel sperm fibrous sheath protein and autoantigen.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 3'-5' exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 3'-5' exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to reactive oxygen species	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in flagellated sperm motility	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in spermatid development	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of outer dynein arm	IEA Inferred from Electronic Annotation more info
part_of outer dynein arm	ISO Inferred from Sequence Orthology more info
located_in sperm cytoplasmic droplet	IEA Inferred from Electronic Annotation more info
located_in sperm cytoplasmic droplet	ISO Inferred from Sequence Orthology more info
located_in sperm fibrous sheath	IDA Inferred from Direct Assay more info	PubMed
located_in sperm midpiece	IEA Inferred from Electronic Annotation more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info
is_active_in sperm principal piece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm principal piece	IEA Inferred from Electronic Annotation more info
located_in sperm principal piece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thioredoxin domain-containing protein 3

Names: 3'-5' exonuclease NME8; spermatid-specific thioredoxin-2 protein; sptrx-2; thioredoxin domain containing 3 (spermatozoa)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198792.3 → NP_942087.2 thioredoxin domain-containing protein 3

See identical proteins and their annotated locations for NP_942087.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8L2R1L1, F7EU06

Conserved Domains (3) summary

cd00595
Location:458 → 589

NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...

cd02948
Location:11 → 113

TRX_NDPK; TRX domain, TRX and NDP-kinase (NDPK) fusion protein family; most members of this group are fusion proteins which contain one redox active TRX domain containing a CXXC motif and three NDPK domains, and are characterized as intermediate chains (ICs) of ...

cd04416
Location:323 → 455

NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

49932861..50000610

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017600636.3 → XP_017456125.1 thioredoxin domain-containing protein 3 isoform X1

UniProtKB/TrEMBL

A0A8L2R1L1, F7EU06

Conserved Domains (3) summary

cd00595
Location:458 → 589

NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...

cd02948
Location:11 → 113

TRX_NDPK; TRX domain, TRX and NDP-kinase (NDPK) fusion protein family; most members of this group are fusion proteins which contain one redox active TRX domain containing a CXXC motif and three NDPK domains, and are characterized as intermediate chains (ICs) of ...

cd04416
Location:323 → 455

NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...
XM_039095975.2 → XP_038951903.1 thioredoxin domain-containing protein 3 isoform X1

UniProtKB/TrEMBL

A0A8L2R1L1, F7EU06

Related

ENSRNOP00000068777.3, ENSRNOT00000090021.3

Conserved Domains (3) summary

cd00595
Location:458 → 589

NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...

cd02948
Location:11 → 113

TRX_NDPK; TRX domain, TRX and NDP-kinase (NDPK) fusion protein family; most members of this group are fusion proteins which contain one redox active TRX domain containing a CXXC motif and three NDPK domains, and are characterized as intermediate chains (ICs) of ...

cd04416
Location:323 → 455

NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...
XM_063276669.1 → XP_063132739.1 thioredoxin domain-containing protein 3 isoform X2

UniProtKB/TrEMBL

A0A8L2R1L1
XM_063276670.1 → XP_063132740.1 thioredoxin domain-containing protein 3 isoform X2

UniProtKB/TrEMBL

A0A8L2R1L1
XM_039095976.2 → XP_038951904.1 thioredoxin domain-containing protein 3 isoform X1

UniProtKB/TrEMBL

A0A8L2R1L1, F7EU06

Conserved Domains (3) summary

cd00595
Location:458 → 589

NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...

cd02948
Location:11 → 113

TRX_NDPK; TRX domain, TRX and NDP-kinase (NDPK) fusion protein family; most members of this group are fusion proteins which contain one redox active TRX domain containing a CXXC motif and three NDPK domains, and are characterized as intermediate chains (ICs) of ...

cd04416
Location:323 → 455

NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...
XM_017600637.2 → XP_017456126.1 thioredoxin domain-containing protein 3 isoform X2

UniProtKB/TrEMBL

A0A8L2R1L1

Related

ENSRNOP00000069890.2, ENSRNOT00000092051.3
XM_039095979.1 → XP_038951907.1 thioredoxin domain-containing protein 3 isoform X5

Conserved Domains (2) summary

cd02948
Location:11 → 113

TRX_NDPK; TRX domain, TRX and NDP-kinase (NDPK) fusion protein family; most members of this group are fusion proteins which contain one redox active TRX domain containing a CXXC motif and three NDPK domains, and are characterized as intermediate chains (ICs) of ...

cl00335
Location:155 → 311

NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...
XM_063276671.1 → XP_063132741.1 thioredoxin domain-containing protein 3 isoform X3
XM_039095978.2 → XP_038951906.1 thioredoxin domain-containing protein 3 isoform X4

Conserved Domains (3) summary

cd00595
Location:296 → 427

NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...

cd04416
Location:161 → 293

NDPk_TX; NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which ...

cl00335
Location:14 → 149

NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...