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    Inpp4b inositol polyphosphate-4-phosphatase type II B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116699, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Inpp4bprovided by RGD
    Official Full Name
    inositol polyphosphate-4-phosphatase type II Bprovided by RGD
    Primary source
    RGD:620470
    See related
    EnsemblRapid:ENSRNOG00000018382 AllianceGenome:RGD:620470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Acts upstream of or within phosphatidylinositol dephosphorylation. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human INPP4B (inositol polyphosphate-4-phosphatase type II B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 201.6), Thymus (RPKM 167.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Inpp4b in Genome Data Viewer
    Location:
    19q11
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (42824710..43575039, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (25920189..26670085, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (29592889..30341528, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene interleukin 15 Neighboring gene uncharacterized LOC134483507 Neighboring gene uncharacterized LOC134483338 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, pseudogene 6 Neighboring gene U2 spliceosomal RNA Neighboring gene ribosomal protein S15, pseudogene 8 Neighboring gene ribosomal protein L35, pseudogene 11 Neighboring gene ubiquitin specific peptidase 38

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. Norris FA, et al. J Biol Chem, 1997 Sep 19. PMID 9295334
    2. Role of the inositol polyphosphate-4-phosphatase type II Inpp4b in the generation of ovarian teratomas. Balakrishnan A, et al. Dev Biol, 2013 Jan 1. PMID 23078915, Free PMC Article
    3. Characterization of the murine Inpp4b gene and identification of a novel isoform. Ferron M, et al. Gene, 2006 Jul 5. PMID 16631325
    4. Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans. Ferron M, et al. Cell Metab, 2011 Oct 5. PMID 21982707, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables inositol-1,3,4-trisphosphate 4-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-3,4-bisphosphate 4-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol bisphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol trisphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of bone remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    type II inositol 3,4-bisphosphate 4-phosphatase
    Names
    inositol polyphosphate 4-phosphatase type II
    inositol polyphosphate-4-phosphatase, type II, 105kD
    NP_446369.1
    XP_008770684.1
    XP_017456652.1
    XP_017456654.1
    XP_038953356.1
    XP_038953357.1
    XP_038953358.1
    XP_038953362.1
    XP_038953363.1
    XP_063133804.1
    XP_063133806.1
    XP_063133807.1
    XP_063133808.1
    XP_063133809.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431397.1 → NP_001418326.1  type II inositol 3,4-bisphosphate 4-phosphatase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IYG6

    2. NM_053917.2 → NP_446369.1  type II inositol 3,4-bisphosphate 4-phosphatase

      See identical proteins and their annotated locations for NP_446369.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IYG6
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      42824710..43575039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277738.1 → XP_063133808.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X5

    2. XM_063277736.1 → XP_063133806.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X3

      UniProtKB/Swiss-Prot
      O35825, Q9QWG5
      UniProtKB/TrEMBL
      A6IYG5
      Related
      ENSRNOP00000024981.4, ENSRNOT00000024981.8

    3. XM_017601165.3 → XP_017456654.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X4

      UniProtKB/TrEMBL
      A0A8I6A1I3
      Conserved Domains (1) summary
      cd04048
      Location:39 → 158
      C2A_Copine; C2 domain first repeat in Copine

    4. XM_039097430.2 → XP_038953358.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X2

      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    5. XM_017601163.3 → XP_017456652.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    6. XM_063277734.1 → XP_063133804.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

      UniProtKB/TrEMBL
      A6IYG6

    7. XM_039097428.2 → XP_038953356.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

      UniProtKB/TrEMBL
      A6IYG6
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    8. XM_063277739.1 → XP_063133809.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X6

    9. XM_039097429.2 → XP_038953357.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

      UniProtKB/TrEMBL
      A6IYG6
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    10. XM_063277737.1 → XP_063133807.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X4

      UniProtKB/TrEMBL
      A0A8I6A1I3
      Related
      ENSRNOP00000085379.1, ENSRNOT00000097624.2

    11. XM_008772462.4 → XP_008770684.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_008770684.1

      UniProtKB/TrEMBL
      A6IYG6
      Related
      ENSRNOP00000025013.4, ENSRNOT00000025013.6
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    12. XM_039097435.2 → XP_038953363.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X7

    13. XM_039097434.2 → XP_038953362.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QWG5.1 GenPept UniProtKB/Swiss-Prot:Q9QWG5

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