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    Adgrl2 adhesion G protein-coupled receptor L2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171447, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Adgrl2provided by RGD
    Official Full Name
    adhesion G protein-coupled receptor L2provided by RGD
    Primary source
    RGD:620835
    See related
    EnsemblRapid:ENSRNOG00000065347 AllianceGenome:RGD:620835
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cirl2; Cl2ac; Lphn2; Cirl-2
    Summary
    Enables PDZ domain binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and synapse organization. Predicted to act upstream of or within positive regulation of synapse assembly and response to bacterium. Predicted to be located in membrane. Predicted to be active in glutamatergic synapse and postsynaptic membrane. Orthologous to human ADGRL2 (adhesion G protein-coupled receptor L2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 155.2), Liver (RPKM 125.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adgrl2 in Genome Data Viewer
    Location:
    2q45
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (240356176..240987246, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (237696055..238327141, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (258792838..258997145, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134486003 Neighboring gene uncharacterized LOC120101103 Neighboring gene uncharacterized LOC102547720 Neighboring gene uncharacterized LOC134486004 Neighboring gene uncharacterized LOC102547649 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120101101 Neighboring gene uncharacterized LOC134486005 Neighboring gene uncharacterized LOC102547779

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly. Anderson GR, et al. J Cell Biol, 2017 Nov 6. PMID 28972101, Free PMC Article
    2. A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors. Ichtchenko K, et al. J Biol Chem, 1999 Feb 26. PMID 10026162
    3. A de novo variant in ADGRL2 suggests a novel mechanism underlying the previously undescribed association of extreme microcephaly with severely reduced sulcation and rhombencephalosynapsis. Vezain M, et al. Acta Neuropathol Commun, 2018 Oct 19. PMID 30340542, Free PMC Article
    4. alpha-Latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis. Sugita S, et al. J Biol Chem, 1998 Dec 4. PMID 9830014
    5. The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. Kreienkamp HJ, et al. J Biol Chem, 2000 Oct 20. PMID 10964907

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor L2
    Names
    calcium-independent alpha-latrotoxin receptor 2
    calcium-independent alpha-latrotoxin receptor homolog 2
    latrophilin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190475.2 → NP_001177404.2  adhesion G protein-coupled receptor L2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001177404.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AA899882, AF063102, AF081153, CB579130, CO556290, FM039554, FM068641, FM099106
      UniProtKB/TrEMBL
      A0A8I6A5I7, A6HWH0, D3ZBE9
      Related
      ENSRNOP00000042136.6, ENSRNOT00000045905.7
      Conserved Domains (8) summary
      smart00303
      Location:788 → 840
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:469 → 533
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1119 → 1478
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:542 → 764
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:850 → 875
      7tm_GPCRs; TM helix 1 [structural motif]
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain
      cl28897
      Location:848 → 1120
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001302208.1 → NP_001289137.1  adhesion G protein-coupled receptor L2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001289137.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon and has an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is shorter and lacks two internal segments, compared to isoform 1.
      Source sequence(s)
      AA899882, AF063102, AF081151, CB579130, CO556290, FM039554, FM068641, FM099106
      UniProtKB/TrEMBL
      A6HWG7
      Related
      ENSRNOP00000098507.2, ENSRNOT00000120902.2
      Conserved Domains (8) summary
      smart00303
      Location:788 → 840
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:469 → 533
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1119 → 1467
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:542 → 764
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:850 → 875
      7tm_GPCRs; TM helix 1 [structural motif]
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain
      cl28897
      Location:848 → 1120
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. NM_001302209.1 → NP_001289138.1  adhesion G protein-coupled receptor L2 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001289138.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two consecutive exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (4) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AA899882, AF063102, AF081150, CB579130, CO556290, FM039554, FM068641, FM099106
      UniProtKB/TrEMBL
      A6HWG5
      Related
      ENSRNOP00000098504.2, ENSRNOT00000120899.2
      Conserved Domains (8) summary
      smart00303
      Location:788 → 840
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:469 → 533
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1104 → 1463
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:542 → 764
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:850 → 875
      7tm_GPCRs; TM helix 1 [structural motif]
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain
      cl28897
      Location:848 → 1105
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. NM_001302210.1 → NP_001289139.1  adhesion G protein-coupled receptor L2 isoform 5 precursor

      See identical proteins and their annotated locations for NP_001289139.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two consecutive exons and has an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (5) lacks two internal segments, compared to isoform 1.
      Source sequence(s)
      AA899882, AF063102, AF081148, CB579130, CO556290, FM039554, FM068641, FM099106
      UniProtKB/TrEMBL
      A6HWG0
      Conserved Domains (8) summary
      smart00303
      Location:788 → 840
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:469 → 533
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1104 → 1452
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:542 → 764
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:850 → 875
      7tm_GPCRs; TM helix 1 [structural motif]
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain
      cl28897
      Location:848 → 1105
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. NM_001302211.1 → NP_001289140.1  adhesion G protein-coupled receptor L2 isoform 6 precursor

      See identical proteins and their annotated locations for NP_001289140.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two in-frame exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (6) lacks two internal segments, compared to isoform 1.
      Source sequence(s)
      AA899882, AF063102, AF081152, CB579130, CO556290, FM039554, FM068641, FM099106
      UniProtKB/TrEMBL
      A0A8I5ZZY9, A6HWG9
      Conserved Domains (8) summary
      smart00303
      Location:788 → 840
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:469 → 533
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1119 → 1435
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:542 → 764
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:850 → 875
      7tm_GPCRs; TM helix 1 [structural motif]
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain
      cl28897
      Location:848 → 1120
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    6. NM_001302212.1 → NP_001289141.1  adhesion G protein-coupled receptor L2 isoform 7 precursor

      See identical proteins and their annotated locations for NP_001289141.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks three exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (7) lacks two internal segments, compared to isoform 1.
      Source sequence(s)
      AA899882, AF063102, AF081149, CB579130, CO556290, FM039554, FM068641, FM099106
      UniProtKB/TrEMBL
      A6HWG3
      Conserved Domains (8) summary
      smart00303
      Location:788 → 840
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:469 → 533
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1104 → 1420
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:542 → 764
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:850 → 875
      7tm_GPCRs; TM helix 1 [structural motif]
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain
      cl28897
      Location:848 → 1105
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    7. NM_134408.3 → NP_599235.3  adhesion G protein-coupled receptor L2 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA899882, AF063102, AF081148, AF081151, CB579130, CO556290, FM039554, FM068641, FM099106
      UniProtKB/Swiss-Prot
      O88918, O88919, O88920, O88921, O88922, O88923, Q9Z174
      UniProtKB/TrEMBL
      F1M7T0
      Conserved Domains (8) summary
      smart00303
      Location:788 → 840
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:469 → 533
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1128 → 1487
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:542 → 764
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:850 → 875
      7tm_GPCRs; TM helix 1 [structural motif]
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain
      cl28897
      Location:848 → 1129
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      240356176..240987246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281223.1 → XP_063137293.1  adhesion G protein-coupled receptor L2 isoform X1

    2. XM_063281268.1 → XP_063137338.1  adhesion G protein-coupled receptor L2 isoform X40

    3. XM_063281246.1 → XP_063137316.1  adhesion G protein-coupled receptor L2 isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZUN4

    4. XM_063281234.1 → XP_063137304.1  adhesion G protein-coupled receptor L2 isoform X10

    5. XM_063281264.1 → XP_063137334.1  adhesion G protein-coupled receptor L2 isoform X37

    6. XM_063281231.1 → XP_063137301.1  adhesion G protein-coupled receptor L2 isoform X7

    7. XM_063281225.1 → XP_063137295.1  adhesion G protein-coupled receptor L2 isoform X1

    8. XM_063281245.1 → XP_063137315.1  adhesion G protein-coupled receptor L2 isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZUN4

    9. XM_063281266.1 → XP_063137336.1  adhesion G protein-coupled receptor L2 isoform X38

    10. XM_063281239.1 → XP_063137309.1  adhesion G protein-coupled receptor L2 isoform X16

    11. XM_063281224.1 → XP_063137294.1  adhesion G protein-coupled receptor L2 isoform X1

    12. XM_063281254.1 → XP_063137324.1  adhesion G protein-coupled receptor L2 isoform X28

    13. XM_063281250.1 → XP_063137320.1  adhesion G protein-coupled receptor L2 isoform X24

    14. XM_063281252.1 → XP_063137322.1  adhesion G protein-coupled receptor L2 isoform X26

    15. XM_063281247.1 → XP_063137317.1  adhesion G protein-coupled receptor L2 isoform X21

    16. XM_063281253.1 → XP_063137323.1  adhesion G protein-coupled receptor L2 isoform X27

    17. XM_063281248.1 → XP_063137318.1  adhesion G protein-coupled receptor L2 isoform X22

    18. XM_063281251.1 → XP_063137321.1  adhesion G protein-coupled receptor L2 isoform X25

    19. XM_063281240.1 → XP_063137310.1  adhesion G protein-coupled receptor L2 isoform X17

    20. XM_063281238.1 → XP_063137308.1  adhesion G protein-coupled receptor L2 isoform X15

    21. XM_063281249.1 → XP_063137319.1  adhesion G protein-coupled receptor L2 isoform X23

    22. XM_039101650.2 → XP_038957578.1  adhesion G protein-coupled receptor L2 isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZUN4, A6HWG3
      Conserved Domains (8) summary
      smart00303
      Location:771 → 823
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1087 → 1403
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:538 → 747
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:833 → 858
      7tm_GPCRs; TM helix 1 [structural motif]
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain
      cl28897
      Location:831 → 1088
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    23. XM_063281265.1 → XP_063137335.1  adhesion G protein-coupled receptor L2 isoform X38

    24. XM_039101639.2 → XP_038957567.1  adhesion G protein-coupled receptor L2 isoform X10

      UniProtKB/TrEMBL
      A6HWG5
      Related
      ENSRNOP00000083029.2, ENSRNOT00000109156.2
      Conserved Domains (8) summary
      smart00303
      Location:771 → 823
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1087 → 1446
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:538 → 747
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:833 → 858
      7tm_GPCRs; TM helix 1 [structural motif]
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain
      cl28897
      Location:831 → 1088
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    25. XM_063281243.1 → XP_063137313.1  adhesion G protein-coupled receptor L2 isoform X18

    26. XM_063281237.1 → XP_063137307.1  adhesion G protein-coupled receptor L2 isoform X14

    27. XM_063281229.1 → XP_063137299.1  adhesion G protein-coupled receptor L2 isoform X6

    28. XM_063281230.1 → XP_063137300.1  adhesion G protein-coupled receptor L2 isoform X8

    29. XM_063281227.1 → XP_063137297.1  adhesion G protein-coupled receptor L2 isoform X4

    30. XM_063281244.1 → XP_063137314.1  adhesion G protein-coupled receptor L2 isoform X19

    31. XM_063281232.1 → XP_063137302.1  adhesion G protein-coupled receptor L2 isoform X9

    32. XM_039101645.2 → XP_038957573.1  adhesion G protein-coupled receptor L2 isoform X16

      UniProtKB/TrEMBL
      A6HWG3
      Conserved Domains (8) summary
      smart00303
      Location:784 → 836
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1100 → 1416
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:538 → 760
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:846 → 871
      7tm_GPCRs; TM helix 1 [structural motif]
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain
      cl28897
      Location:844 → 1101
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    33. XM_063281263.1 → XP_063137333.1  adhesion G protein-coupled receptor L2 isoform X37

    34. XM_039101637.2 → XP_038957565.1  adhesion G protein-coupled receptor L2 isoform X7

      UniProtKB/TrEMBL
      A6HWG5
      Related
      ENSRNOP00000098502.2, ENSRNOT00000120897.2
      Conserved Domains (8) summary
      smart00303
      Location:784 → 836
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1100 → 1459
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:538 → 760
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:846 → 871
      7tm_GPCRs; TM helix 1 [structural motif]
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain
      cl28897
      Location:844 → 1101
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    35. XM_063281228.1 → XP_063137298.1  adhesion G protein-coupled receptor L2 isoform X5

    36. XM_063281235.1 → XP_063137305.1  adhesion G protein-coupled receptor L2 isoform X12

    37. XM_039101632.2 → XP_038957560.1  adhesion G protein-coupled receptor L2 isoform X2

      UniProtKB/TrEMBL
      A6HWH0, D3ZBE9
      Related
      ENSRNOP00000089949.3, ENSRNOT00000116263.3
      Conserved Domains (8) summary
      smart00303
      Location:784 → 836
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1115 → 1474
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:538 → 760
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:846 → 871
      7tm_GPCRs; TM helix 1 [structural motif]
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain
      cl28897
      Location:844 → 1116
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    38. XM_063281236.1 → XP_063137306.1  adhesion G protein-coupled receptor L2 isoform X13

    39. XM_063281261.1 → XP_063137331.1  adhesion G protein-coupled receptor L2 isoform X35

    40. XM_063281226.1 → XP_063137296.1  adhesion G protein-coupled receptor L2 isoform X3

    41. XM_063281233.1 → XP_063137303.1  adhesion G protein-coupled receptor L2 isoform X11

      Related
      ENSRNOP00000095749.2, ENSRNOT00000095993.2

    42. XM_063281259.1 → XP_063137329.1  adhesion G protein-coupled receptor L2 isoform X33

    43. XM_063281222.1 → XP_063137292.1  adhesion G protein-coupled receptor L2 isoform X1

    44. XM_063281255.1 → XP_063137325.1  adhesion G protein-coupled receptor L2 isoform X29

    45. XM_063281257.1 → XP_063137327.1  adhesion G protein-coupled receptor L2 isoform X31

    46. XM_063281256.1 → XP_063137326.1  adhesion G protein-coupled receptor L2 isoform X30

    47. XM_063281258.1 → XP_063137328.1  adhesion G protein-coupled receptor L2 isoform X32

    48. XM_063281262.1 → XP_063137332.1  adhesion G protein-coupled receptor L2 isoform X36

    49. XM_063281260.1 → XP_063137330.1  adhesion G protein-coupled receptor L2 isoform X34

    50. XM_063281267.1 → XP_063137337.1  adhesion G protein-coupled receptor L2 isoform X39

      Related
      ENSRNOP00000098509.2, ENSRNOT00000120904.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88923.2 GenPept UniProtKB/Swiss-Prot:O88923

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