Slc7a11 solute carrier family 7 member 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc7a11provided by RGD
Official Full Name: solute carrier family 7 member 11provided by RGD
Primary source: RGD:1309275
See related: EnsemblRapid:ENSRNOG00000010210 AllianceGenome:RGD:1309275
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable L-kynurenine transmembrane transporter activity and cystine:glutamate antiporter activity. Involved in lens fiber cell differentiation; response to nicotine; and response to oxidative stress. Predicted to be located in several cellular components, including astrocyte projection; brush border membrane; and cell surface. Orthologous to human SLC7A11 (solute carrier family 7 member 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 682.1), Brain (RPKM 145.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 2q26

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (136532912..136668560, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (134382002..134517622, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (139453774..139528479, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role and possible mechanism of the ferroptosis-related SLC7A11/GSH/GPX4 pathway in myocardial ischemia-reperfusion injury.
Title: The role and possible mechanism of the ferroptosis-related SLC7A11/GSH/GPX4 pathway in myocardial ischemia-reperfusion injury.
MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis.
Title: MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis.
miR-432-5p Inhibits the Ferroptosis in Cardiomyocytes Induced by Hypoxia/Reoxygenation via Activating Nrf2/SLC7A11 Axis by Degrading Keap1.
Title: miR-432-5p Inhibits the Ferroptosis in Cardiomyocytes Induced by Hypoxia/Reoxygenation via Activating Nrf2/SLC7A11 Axis by Degrading Keap1.
Exosomes from osteoarthritic fibroblast-like synoviocytes promote cartilage ferroptosis and damage via delivering microRNA-19b-3p to target SLC7A11 in osteoarthritis.
Title: Exosomes from osteoarthritic fibroblast-like synoviocytes promote cartilage ferroptosis and damage via delivering microRNA-19b-3p to target SLC7A11 in osteoarthritis.
Exosomal circBBS2 inhibits ferroptosis by targeting miR-494 to activate SLC7A11 signaling in ischemic stroke.
Title: Exosomal circBBS2 inhibits ferroptosis by targeting miR-494 to activate SLC7A11 signaling in ischemic stroke.
Inhibition of Connexin43 Improves the Recovery of Spinal Cord Injury Against Ferroptosis via the SLC7A11/GPX4 Pathway.
Title: Inhibition of Connexin43 Improves the Recovery of Spinal Cord Injury Against Ferroptosis via the SLC7A11/GPX4 Pathway.
Inhibition of MALT1 reduces ferroptosis in rat hearts following ischemia/reperfusion via enhancing the Nrf2/SLC7A11 pathway.
Title: Inhibition of MALT1 reduces ferroptosis in rat hearts following ischemia/reperfusion via enhancing the Nrf2/SLC7A11 pathway.
Iron overload facilitates neonatal hypoxic-ischemic brain damage via SLC7A11-mediated ferroptosis.
Title: Iron overload facilitates neonatal hypoxic-ischemic brain damage via SLC7A11-mediated ferroptosis.
MicroRNA-27a Regulates Ferroptosis Through SLC7A11 to Aggravate Cerebral ischemia-reperfusion Injury.
Title: MicroRNA-27a Regulates Ferroptosis Through SLC7A11 to Aggravate Cerebral ischemia-reperfusion Injury.
[miR-27a induces ferroptosis by inhibiting solute carrier family 7 member-11 (SLC7A11) and causes cerebral ischemia-reperfusion injury in rats].
Title: [miR-27a induces ferroptosis by inhibiting solute carrier family 7 member-11 (SLC7A11) and causes cerebral ischemia-reperfusion injury in rats].

Submit: New GeneRIF Correction See all GeneRIFs (23)

General gene information

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Markers

RH135019 (e-PCR)
- UniSTS:218296

Slc7a11 (e-PCR), detects polymorphism
- UniSTS:546024

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-kynurenine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables cystine:glutamate antiporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-cystine transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within L-glutamate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-kynurenine transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult behavior	ISO Inferred from Sequence Orthology more info
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dipeptide import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glutathione metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glutathione transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular glutamate homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lens fiber cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within limb development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ferroptosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet aggregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of AMPA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cysteine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of glutamate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of glutathione biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of melanin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neutrophil apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synapse organization	ISO Inferred from Sequence Orthology more info
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to redox state	ISO Inferred from Sequence Orthology more info
involved_in response to toxic substance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within striatum development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cystine/glutamate transporter

Names: solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11; solute carrier family 7 (cationic amino acid transporter, y+ system), member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107673.3 → NP_001101143.2 cystine/glutamate transporter

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I6AB70, D4ADU2

Related

ENSRNOP00000091221.2, ENSRNOT00000114420.3

Conserved Domains (2) summary

TIGR00911
Location:1 → 498

2A0308; L-type amino acid transporter

cl00456
Location:42 → 291

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

136532912..136668560 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102260.2 → XP_038958188.1 cystine/glutamate transporter isoform X3

UniProtKB/TrEMBL

D4ADU2

Conserved Domains (1) summary

TIGR00911
Location:1 → 440

2A0308; L-type amino acid transporter
XM_039102258.2 → XP_038958186.1 cystine/glutamate transporter isoform X1

UniProtKB/TrEMBL

D4ADU2

Related

ENSRNOP00000098235.1, ENSRNOT00000120596.2

Conserved Domains (1) summary

TIGR00911
Location:1 → 482

2A0308; L-type amino acid transporter
XM_063281786.1 → XP_063137856.1 cystine/glutamate transporter isoform X4

UniProtKB/TrEMBL

D4ADU2
XM_039102259.2 → XP_038958187.1 cystine/glutamate transporter isoform X2

UniProtKB/TrEMBL

D4ADU2

Conserved Domains (1) summary

TIGR00911
Location:1 → 483

2A0308; L-type amino acid transporter