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    Ap4b1 adaptor related protein complex 4 subunit beta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310746, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ap4b1provided by RGD
    Official Full Name
    adaptor related protein complex 4 subunit beta 1provided by RGD
    Primary source
    RGD:1310529
    See related
    EnsemblRapid:ENSRNOG00000019455 AllianceGenome:RGD:1310529
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable clathrin binding activity. Predicted to be involved in protein localization to somatodendritic compartment; protein targeting; and vesicle-mediated transport. Predicted to be located in cytoplasmic side of trans-Golgi network transport vesicle membrane; cytosol; and trans-Golgi network. Predicted to be part of AP-4 adaptor complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 47. Orthologous to human AP4B1 (adaptor related protein complex 4 subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 135.2), Spleen (RPKM 98.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ap4b1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (194006926..194018971)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (191318485..191330531)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (206293679..206305705)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene homeodomain interacting protein kinase 1 Neighboring gene uncharacterized LOC108350077 Neighboring gene DNA cross-link repair 1B Neighboring gene Bcl2-like 15 Neighboring gene ribosomal protein L36A, pseudogene 15 Neighboring gene protein tyrosine phosphatase, non-receptor type 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of a fourth adaptor-related protein complex. Hirst J, et al. Mol Biol Cell, 1999 Aug. PMID 10436028, Free PMC Article
    2. AP-4, a novel protein complex related to clathrin adaptors. Dell'Angelica EC, et al. J Biol Chem, 1999 Mar 12. PMID 10066790
    3. Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4. Matsuda S, et al. Neuron, 2008 Mar 13. PMID 18341993
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to somatodendritic compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-4 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of trans-Golgi network transport vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AP-4 complex subunit beta-1
    Names
    adaptor-related protein complex 4, beta 1 subunit
    adaptor-related protein complex AP-4, beta 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107709.1 → NP_001101179.1  AP-4 complex subunit beta-1

      See identical proteins and their annotated locations for NP_001101179.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474015
      UniProtKB/TrEMBL
      A0A8I6A896, A0A8I6AM43, A6K3M9
      Conserved Domains (3) summary
      sd00044
      Location:86 → 113
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:9 → 525
      Adaptin_N; Adaptin N terminal region
      pfam09066
      Location:621 → 730
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      194006926..194018971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590915.2 → XP_017446404.1  AP-4 complex subunit beta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A896, A0A8I6AM43, A6K3M9
      Conserved Domains (3) summary
      sd00044
      Location:86 → 113
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:9 → 525
      Adaptin_N; Adaptin N terminal region
      pfam09066
      Location:621 → 730
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

    2. XM_006233081.5 → XP_006233143.1  AP-4 complex subunit beta-1 isoform X1

      See identical proteins and their annotated locations for XP_006233143.1

      UniProtKB/TrEMBL
      A0A8I6A896, A0A8I6AM43, A6K3M9
      Related
      ENSRNOP00000087320.1, ENSRNOT00000112010.2
      Conserved Domains (3) summary
      sd00044
      Location:86 → 113
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:9 → 525
      Adaptin_N; Adaptin N terminal region
      pfam09066
      Location:621 → 730
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

    3. XM_063281908.1 → XP_063137978.1  AP-4 complex subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      D4AD35
      Related
      ENSRNOP00000026382.5, ENSRNOT00000026382.7

    4. XM_063281909.1 → XP_063137979.1  AP-4 complex subunit beta-1 isoform X4

    5. XM_063281910.1 → XP_063137980.1  AP-4 complex subunit beta-1 isoform X5

    6. XM_039102411.2 → XP_038958339.1  AP-4 complex subunit beta-1 isoform X6

      Conserved Domains (2) summary
      sd00044
      Location:86 → 113
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:9 → 401
      Adaptin_N; Adaptin N terminal region

    7. XM_039102410.1 → XP_038958338.1  AP-4 complex subunit beta-1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GCJ1
      Related
      ENSRNOP00000085168.1, ENSRNOT00000112580.2
      Conserved Domains (2) summary
      smart01020
      Location:414 → 526
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      pfam01602
      Location:4 → 319
      Adaptin_N; Adaptin N terminal region

    8. XM_039102409.2 → XP_038958337.1  AP-4 complex subunit beta-1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GCJ1
      Conserved Domains (2) summary
      smart01020
      Location:414 → 526
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      pfam01602
      Location:4 → 319
      Adaptin_N; Adaptin N terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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