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    Ciz1 CDKN1A interacting zinc finger protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296639, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ciz1provided by RGD
    Official Full Name
    CDKN1A interacting zinc finger protein 1provided by RGD
    Primary source
    RGD:1305336
    See related
    EnsemblRapid:ENSRNOG00000013442 AllianceGenome:RGD:1305336
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cyclin binding activity. Predicted to be involved in random inactivation of X chromosome. Predicted to act upstream of or within maintenance of protein location in nucleus and positive regulation of DNA-templated DNA replication initiation. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in nucleus. Orthologous to human CIZ1 (CDKN1A interacting zinc finger protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 58.9), Heart (RPKM 58.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ciz1 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36055753..36071510)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15658479..15673762)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11392046..11409218)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene golgin A2 Neighboring gene dynamin 1 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC134486070 Neighboring gene bublin coiled coil protein Neighboring gene lipocalin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. C-terminal domains deliver the DNA replication factor Ciz1 to the nuclear matrix. Ainscough JF, et al. J Cell Sci, 2007 Jan 1. PMID 17182902
    2. Ciz1 promotes mammalian DNA replication. Coverley D, et al. J Cell Sci, 2005 Jan 1. PMID 15585571
    3. Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro. Copeland NA, et al. J Cell Sci, 2010 Apr 1. PMID 20215406, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within maintenance of protein location in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in random inactivation of X chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cip1-interacting zinc finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399357.1 → NP_001386286.1  cip1-interacting zinc finger protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      B2RYH1, F1LS75
      Conserved Domains (4) summary
      smart00451
      Location:485 → 517
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:93 → 403
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:549 → 569
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:579 → 603
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    2. NM_001399358.1 → NP_001386287.1  cip1-interacting zinc finger protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AJV2, B2RYH1
      Related
      ENSRNOP00000035313.8, ENSRNOT00000037399.8
      Conserved Domains (4) summary
      smart00451
      Location:481 → 513
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:93 → 399
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:545 → 565
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:575 → 599
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    3. NM_001399359.1 → NP_001386288.1  cip1-interacting zinc finger protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      B2RYH1
      Conserved Domains (4) summary
      smart00451
      Location:388 → 420
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:2 → 306
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:452 → 472
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:482 → 506
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      36055753..36071510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761719.4 → XP_008759941.2  cip1-interacting zinc finger protein isoform X6

      UniProtKB/TrEMBL
      B2RYH1
      Conserved Domains (4) summary
      smart00451
      Location:476 → 508
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:93 → 394
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:540 → 560
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:570 → 594
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    2. XM_006233941.5 → XP_006234003.1  cip1-interacting zinc finger protein isoform X1

      See identical proteins and their annotated locations for XP_006234003.1

      UniProtKB/TrEMBL
      A6JU56, F1LV60
      Conserved Domains (4) summary
      smart00451
      Location:532 → 564
      ZnF_U1; U1-like zinc finger
      COG5112
      Location:606 → 657
      UFD2; U1-like Zn-finger-containing protein [General function prediction only]
      sd00020
      Location:596 → 616
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:626 → 650
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    3. XM_063283494.1 → XP_063139564.1  cip1-interacting zinc finger protein isoform X3

      UniProtKB/TrEMBL
      B2RYH1, F1LS75

    4. XM_063283496.1 → XP_063139566.1  cip1-interacting zinc finger protein isoform X4

      UniProtKB/TrEMBL
      A0A8I6AJV2, B2RYH1

    5. XM_006233943.4 → XP_006234005.1  cip1-interacting zinc finger protein isoform X2

      UniProtKB/TrEMBL
      A6JU56
      Conserved Domains (4) summary
      smart00451
      Location:527 → 559
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:109 → 456
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:591 → 611
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:621 → 645
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    6. XM_063283497.1 → XP_063139567.1  cip1-interacting zinc finger protein isoform X5

      UniProtKB/TrEMBL
      B2RYH1

    7. XM_063283499.1 → XP_063139569.1  cip1-interacting zinc finger protein isoform X6

      UniProtKB/TrEMBL
      B2RYH1

    8. XM_063283500.1 → XP_063139570.1  cip1-interacting zinc finger protein isoform X7

      UniProtKB/TrEMBL
      A6JU56

    9. XM_063283501.1 → XP_063139571.1  cip1-interacting zinc finger protein isoform X8

      UniProtKB/TrEMBL
      B2RYH1

    10. XM_063283502.1 → XP_063139572.1  cip1-interacting zinc finger protein isoform X9

      UniProtKB/TrEMBL
      B2RYH1

    11. XM_063283503.1 → XP_063139573.1  cip1-interacting zinc finger protein isoform X10

      UniProtKB/TrEMBL
      B2RYH1

    12. XM_063283504.1 → XP_063139574.1  cip1-interacting zinc finger protein isoform X11

    13. XM_006233940.4 → XP_006234002.1  cip1-interacting zinc finger protein isoform X1

      See identical proteins and their annotated locations for XP_006234002.1

      UniProtKB/TrEMBL
      A6JU56, F1LV60
      Related
      ENSRNOP00000083181.1, ENSRNOT00000107806.2
      Conserved Domains (4) summary
      smart00451
      Location:532 → 564
      ZnF_U1; U1-like zinc finger
      COG5112
      Location:606 → 657
      UFD2; U1-like Zn-finger-containing protein [General function prediction only]
      sd00020
      Location:596 → 616
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:626 → 650
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    14. XM_008761715.3 → XP_008759937.2  cip1-interacting zinc finger protein isoform X2

      UniProtKB/TrEMBL
      A6JU56
      Conserved Domains (4) summary
      smart00451
      Location:527 → 559
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:109 → 456
      PHA03247; large tegument protein UL36; Provisional
      sd00020
      Location:591 → 611
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:621 → 645
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    15. XM_063283498.1 → XP_063139568.1  cip1-interacting zinc finger protein isoform X5

      UniProtKB/TrEMBL
      B2RYH1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106568.1: Suppressed sequence

      Description
      NM_001106568.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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