Ssrp1 structure specific recognition protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ssrp1provided by RGD
Official Full Name: structure specific recognition protein 1provided by RGD
Primary source: RGD:621143
See related: EnsemblRapid:ENSRNOG00000008825 AllianceGenome:RGD:621143
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable histone binding activity and nucleosome binding activity. Predicted to be involved in nucleosome disassembly and regulation of chromatin organization. Predicted to be located in nucleus. Predicted to be part of FACT complex. Orthologous to human SSRP1 (structure specific recognition protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 375.5), Spleen (RPKM 361.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (90531024..90541132)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (70124371..70134481)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (72447516..72457621)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in nucleosome disassembly	IEA Inferred from Electronic Annotation more info
involved_in nucleosome disassembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromatin organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of chromatin organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of FACT complex	IBA Inferred from Biological aspect of Ancestor more info
part_of FACT complex	IEA Inferred from Electronic Annotation more info
part_of FACT complex	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: FACT complex subunit SSRP1

Names: T160; facilitates chromatin transcription complex subunit SSRP1; recombination signal sequence recognition protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031121.1 → NP_112383.1 FACT complex subunit SSRP1

See identical proteins and their annotated locations for NP_112383.1

Status: PROVISIONAL

Source sequence(s)

BC083588

UniProtKB/Swiss-Prot

Q04931, Q5XIT2

UniProtKB/TrEMBL

A0A8L2R8I0, A6HMS9

Conserved Domains (4) summary

COG5165
Location:21 → 480

POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]

cd13231
Location:332 → 427

PH2_SSRP1-like; Structure Specific Recognition protein 1 (SSRP1) Pleckstrin homology (PH) domain, repeat 2

pfam00505
Location:547 → 614

HMG_box; HMG (high mobility group) box

pfam03531
Location:75 → 284

SSrecog; Structure-specific recognition protein (SSRP1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

90531024..90541132

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008761993.4 → XP_008760215.3 FACT complex subunit SSRP1 isoform X2

UniProtKB/TrEMBL

A0A8L2R8I0

Conserved Domains (2) summary

COG5165
Location:114 → 573

POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]

pfam00505
Location:640 → 707

HMG_box; HMG (high mobility group) box
XM_063284636.1 → XP_063140706.1 FACT complex subunit SSRP1 isoform X1

UniProtKB/Swiss-Prot

Q04931, Q5XIT2

UniProtKB/TrEMBL

A0A8L2R8I0, A6HMS9
XM_063284634.1 → XP_063140704.1 FACT complex subunit SSRP1 isoform X1

UniProtKB/Swiss-Prot

Q04931, Q5XIT2

UniProtKB/TrEMBL

A0A8L2R8I0, A6HMS9

Related

ENSRNOP00000073084.3, ENSRNOT00000091901.3
XM_006234477.4 → XP_006234539.2 FACT complex subunit SSRP1 isoform X1

UniProtKB/Swiss-Prot

Q04931, Q5XIT2

UniProtKB/TrEMBL

A0A8L2R8I0, A6HMS9

Related

ENSRNOP00000012022.4, ENSRNOT00000012022.6

Conserved Domains (4) summary

COG5165
Location:21 → 480

POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]

cd13231
Location:332 → 427

PH2_SSRP1-like; Structure Specific Recognition protein 1 (SSRP1) Pleckstrin homology (PH) domain, repeat 2

pfam00505
Location:547 → 614

HMG_box; HMG (high mobility group) box

pfam03531
Location:75 → 284

SSrecog; Structure-specific recognition protein (SSRP1)
XM_063284638.1 → XP_063140708.1 FACT complex subunit SSRP1 isoform X1

UniProtKB/Swiss-Prot

Q04931, Q5XIT2

UniProtKB/TrEMBL

A0A8L2R8I0, A6HMS9
XM_063284635.1 → XP_063140705.1 FACT complex subunit SSRP1 isoform X1

UniProtKB/Swiss-Prot

Q04931, Q5XIT2

UniProtKB/TrEMBL

A0A8L2R8I0, A6HMS9
XM_063284637.1 → XP_063140707.1 FACT complex subunit SSRP1 isoform X1

UniProtKB/Swiss-Prot

Q04931, Q5XIT2

UniProtKB/TrEMBL

A0A8L2R8I0, A6HMS9
XM_063284633.1 → XP_063140703.1 FACT complex subunit SSRP1 isoform X1

UniProtKB/Swiss-Prot

Q04931, Q5XIT2

UniProtKB/TrEMBL

A0A8L2R8I0, A6HMS9