Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Magi2provided by RGD
Official Full Name: membrane associated guanylate kinase, WW and PDZ domain containing 2provided by RGD
Primary source: RGD:621855
See related: EnsemblRapid:ENSRNOG00000013962 AllianceGenome:RGD:621855
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AIP-1; S-SCAM; Acvrip1; Acvrinp1
Summary: Enables kinesin binding activity. A structural constituent of postsynaptic density. Involved in several processes, including nerve growth factor signaling pathway; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; and regulation of synaptic membrane adhesion. Located in several cellular components, including late endosome; perinuclear region of cytoplasm; and slit diaphragm. Part of protein-containing complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Is extrinsic component of postsynaptic membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 125.0), Testes (RPKM 44.7) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q11

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (15278518..16762427, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (14386389..15870036, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (10995241..12472423, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chronic restraint stress influences hippocampal neuroplasticity by modulation of dendrite branching pattern and spine density paralleled by increased expression levels of synaptic scaffolding proteins.
Title: Wistar rats subjected to chronic restraint stress display increased hippocampal spine density paralleled by increased expression levels of synaptic scaffolding proteins.
these results suggest that S-SCAM is an essential AMPAR scaffolding molecule for the GluA2-containing pool of AMPARs, which are involved in the constitutive pathway of maintaining synaptic strength.
Title: S-SCAM/MAGI-2 is an essential synaptic scaffolding molecule for the GluA2-containing maintenance pool of AMPA receptors.
We identified Axin as a novel binding partner of S-SCAM. Axin was co-immunoprecipitated with S-SCAM from rat brain
Title: Synaptic scaffolding molecule interacts with axin.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4Got18 (e-PCR)
- UniSTS:115720

AU049234 (e-PCR)
- UniSTS:145682

BF399248 (e-PCR)
- UniSTS:247585

AU046470 (e-PCR)
- UniSTS:111416

D4Rat6 (e-PCR)
- UniSTS:118854

BE106713 (e-PCR)
- UniSTS:246393

AU049610 (e-PCR)
- UniSTS:146056

D0Uwm10 (e-PCR)
- UniSTS:518536

BI301779 (e-PCR)
- UniSTS:246940

D4Wox26 (e-PCR)
- UniSTS:117980

BF388517 (e-PCR)
- UniSTS:244976

RH141994 (e-PCR)
- UniSTS:223985

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	ISS Inferred from Sequence or Structural Similarity more info
enables activin receptor binding	ISO Inferred from Sequence Orthology more info
enables beta-1 adrenergic receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-1 adrenergic receptor binding	IEA Inferred from Electronic Annotation more info
enables beta-1 adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables beta-1 adrenergic receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatase binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor complex adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor complex adaptor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor complex adaptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor complex adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables structural constituent of postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of postsynaptic specialization	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynaptic specialization	IMP Inferred from Mutant Phenotype more info	PubMed
enables type II activin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type II activin receptor binding	ISO Inferred from Sequence Orthology more info
enables type II activin receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in SMAD protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to nerve growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in clathrin-dependent endocytosis	ISO Inferred from Sequence Orthology more info
involved_in clathrin-dependent endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glomerular filtration	IC Inferred by Curator more info	PubMed
involved_in maintenance of postsynaptic density structure	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in nerve growth factor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuroligin clustering involved in postsynaptic membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in podocyte development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic vesicle clustering	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in ciliary base	ISO Inferred from Sequence Orthology more info
located_in ciliary base	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	ISS Inferred from Sequence or Structural Similarity more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in slit diaphragm	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

Names: activin receptor interacting protein 1; atrophin-1-interacting protein 1; membrane-associated guanylate kinase inverted 2; synaptic-scaffolding molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053621.2 → NP_446073.2 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

O88382, Q9R271

UniProtKB/TrEMBL

A0A8I6AQ06, A6K5D2

Related

ENSRNOP00000091952.2, ENSRNOT00000115899.2

Conserved Domains (7) summary

smart00456
Location:350 → 381

WW; Domain with 2 conserved Trp (W) residues

smart00072
Location:118 → 291

GuKc; Guanylate kinase homologues

smart00228
Location:775 → 861

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PRK10263
Location:1007 → 1135

PRK10263; DNA translocase FtsK; Provisional

cd00992
Location:1140 → 1220

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:304 → 333

WW; WW domain

pfam16666
Location:687 → 758

MAGI_u5; Unstructured region on MAGI

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

15278518..16762427 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285370.1 → XP_063141440.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X19
XM_063285374.1 → XP_063141444.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X23
XM_063285367.1 → XP_063141437.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X16
XM_063285355.1 → XP_063141425.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X4

UniProtKB/Swiss-Prot

O88382, Q9R271
XM_063285358.1 → XP_063141428.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X7

UniProtKB/Swiss-Prot

O88382, Q9R271
XM_063285353.1 → XP_063141423.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X2

UniProtKB/Swiss-Prot

O88382, Q9R271
XM_063285359.1 → XP_063141429.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X8

UniProtKB/Swiss-Prot

O88382, Q9R271

UniProtKB/TrEMBL

A0A8I6AD37
XM_063285354.1 → XP_063141424.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X3

UniProtKB/Swiss-Prot

O88382, Q9R271
XM_063285360.1 → XP_063141430.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X9

UniProtKB/Swiss-Prot

O88382, Q9R271
XM_063285357.1 → XP_063141427.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X6

UniProtKB/Swiss-Prot

O88382, Q9R271

UniProtKB/TrEMBL

A0A8I6AH48

Related

ENSRNOP00000095318.2, ENSRNOT00000095227.2
XM_063285356.1 → XP_063141426.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X5

UniProtKB/Swiss-Prot

O88382, Q9R271
XM_063285352.1 → XP_063141422.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1

UniProtKB/Swiss-Prot

O88382, Q9R271
XM_063285373.1 → XP_063141443.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X22

UniProtKB/TrEMBL

A6K5D3, D3ZRR9, D3ZY03
XM_063285361.1 → XP_063141431.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X10
XM_063285372.1 → XP_063141442.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X21
XM_063285375.1 → XP_063141445.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X24
XM_063285377.1 → XP_063141447.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X26
XM_063285381.1 → XP_063141451.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X30
XM_063285378.1 → XP_063141448.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X27
XM_063285382.1 → XP_063141452.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X31
XM_063285380.1 → XP_063141450.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X29
XM_063285376.1 → XP_063141446.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X25
XM_063285366.1 → XP_063141436.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X15

UniProtKB/Swiss-Prot

O88382, Q9R271

Related

ENSRNOP00000090186.2, ENSRNOT00000094238.2
XM_063285364.1 → XP_063141434.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X13

UniProtKB/Swiss-Prot

O88382, Q9R271

Related

ENSRNOP00000059912.5, ENSRNOT00000066643.5
XM_063285362.1 → XP_063141432.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X11

UniProtKB/Swiss-Prot

O88382, Q9R271
XM_063285365.1 → XP_063141435.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X14

UniProtKB/Swiss-Prot

O88382, Q9R271
XM_063285369.1 → XP_063141439.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X18

UniProtKB/Swiss-Prot

O88382, Q9R271
XM_063285371.1 → XP_063141441.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X20

UniProtKB/Swiss-Prot

O88382, Q9R271
XM_063285363.1 → XP_063141433.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X12

UniProtKB/Swiss-Prot

O88382, Q9R271
XM_063285368.1 → XP_063141438.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X17

UniProtKB/Swiss-Prot

O88382, Q9R271
XM_063285379.1 → XP_063141449.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X28