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    Chpf2 chondroitin polymerizing factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296733, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Chpf2provided by RGD
    Official Full Name
    chondroitin polymerizing factor 2provided by RGD
    Primary source
    RGD:1306404
    See related
    EnsemblRapid:ENSRNOG00000010466 AllianceGenome:RGD:1306404
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306404
    Summary
    Predicted to enable glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Predicted to be involved in chondroitin sulfate biosynthetic process. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus. Orthologous to human CHPF2 (chondroitin polymerizing factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 93.7), Brain (RPKM 91.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chpf2 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (11470917..11479096, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10578470..10585940, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7108461..7113940, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486541 Neighboring gene glycerol-3-phosphate dehydrogenase 1 like 3 Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit D3 Neighboring gene microRNA 671 Neighboring gene ATP binding cassette subfamily F member 2 Neighboring gene IQ motif containing with AAA domain 1 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chondroitin sulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chondroitin sulfate glucuronyltransferase
    NP_001100044.1
    XP_008760855.1
    XP_038963146.1
    XP_063141763.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106574.1 → NP_001100044.1  chondroitin sulfate glucuronyltransferase precursor

      See identical proteins and their annotated locations for NP_001100044.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474020
      UniProtKB/TrEMBL
      A0A8I6AI88, A6K535, D4ADR5
      Related
      ENSRNOP00000014082.6, ENSRNOT00000014082.7
      Conserved Domains (2) summary
      pfam05679
      Location:242 → 757
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
      cl21608
      Location:177 → 269
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      11470917..11479096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107218.2 → XP_038963146.1  chondroitin sulfate glucuronyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8I6AI88, A6K535, D4ADR5
      Conserved Domains (2) summary
      pfam05679
      Location:242 → 757
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
      cl21608
      Location:177 → 269
      Galactosyl_T; Galactosyltransferase

    2. XM_008762633.3 → XP_008760855.1  chondroitin sulfate glucuronyltransferase isoform X1

      See identical proteins and their annotated locations for XP_008760855.1

      UniProtKB/TrEMBL
      A0A8I6AI88, A6K535, D4ADR5
      Conserved Domains (2) summary
      pfam05679
      Location:242 → 757
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
      cl21608
      Location:177 → 269
      Galactosyl_T; Galactosyltransferase

    3. XM_063285693.1 → XP_063141763.1  chondroitin sulfate glucuronyltransferase isoform X2

    RNA

    1. XR_010065615.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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