Tia1 TIA1 cytotoxic granule-associated RNA binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tia1provided by RGD
Official Full Name: TIA1 cytotoxic granule-associated RNA binding proteinprovided by RGD
Primary source: RGD:1305742
See related: EnsemblRapid:ENSRNOG00000016813 AllianceGenome:RGD:1305742
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Involved in positive regulation of epithelial cell apoptotic process. Located in cytoplasmic stress granule. Part of ribonucleoprotein complex. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 26. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 172.0), Brain (RPKM 95.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (120410180..120440676)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (118852765..118883252)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (118207845..118238246)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TIAR regulates the relative expression of TIA-1 isoforms.
Title: Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein.

Submit: New GeneRIF Correction

General gene information

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Markers

Tia1 (e-PCR), detects polymorphism
- UniSTS:479294

RH136064 (e-PCR)
- UniSTS:210059

RH138064 (e-PCR)
- UniSTS:220151

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR AU-rich region binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in stress granule assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear stress granule	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytotoxic granule associated RNA binding protein TIA1

Names: cytotoxic granule-associated RNA binding protein 1; nucleolysin TIA-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012096.1 → NP_001012096.1 cytotoxic granule associated RNA binding protein TIA1

See identical proteins and their annotated locations for NP_001012096.1

Status: PROVISIONAL

Source sequence(s)

BC087064

UniProtKB/TrEMBL

F7FKD5, Q5PQR7

Related

ENSRNOP00000094527.1, ENSRNOT00000107832.2

Conserved Domains (4) summary

cd12618
Location:94 → 173

RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

cd12621
Location:203 → 276

RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

TIGR01661
Location:6 → 269

ELAV_HUD_SF; ELAV/HuD family splicing factor

cl17169
Location:8 → 81

RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

120410180..120440676

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236828.4 → XP_006236890.1 cytotoxic granule associated RNA binding protein TIA1 isoform X3

UniProtKB/TrEMBL

A0A8I6AKZ8

Related

ENSRNOP00000096950.2, ENSRNOT00000110929.2

Conserved Domains (4) summary

cd12618
Location:106 → 185

RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

cd12620
Location:215 → 287

RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins

TIGR01661
Location:6 → 281

ELAV_HUD_SF; ELAV/HuD family splicing factor

cl17169
Location:8 → 82

RRM_SF; RNA recognition motif (RRM) superfamily
XM_006236830.5 → XP_006236892.1 cytotoxic granule associated RNA binding protein TIA1 isoform X7

UniProtKB/TrEMBL

F7FKD5

Related

ENSRNOP00000023102.5, ENSRNOT00000023103.6

Conserved Domains (4) summary

cd12618
Location:95 → 174

RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

cd12621
Location:204 → 277

RRM3_TIA1; RNA recognition motif 3 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

TIGR01661
Location:6 → 270

ELAV_HUD_SF; ELAV/HuD family splicing factor

cl17169
Location:8 → 82

RRM_SF; RNA recognition motif (RRM) superfamily
XM_063286065.1 → XP_063142135.1 cytotoxic granule associated RNA binding protein TIA1 isoform X1

UniProtKB/TrEMBL

A0A8I6AKZ8
XM_063286067.1 → XP_063142137.1 cytotoxic granule associated RNA binding protein TIA1 isoform X4

UniProtKB/TrEMBL

F7FKD5
XM_039107613.2 → XP_038963541.1 cytotoxic granule associated RNA binding protein TIA1 isoform X10

UniProtKB/TrEMBL

A0A8I6ASW3

Conserved Domains (1) summary

cl17169
Location:8 → 82

RRM_SF; RNA recognition motif (RRM) superfamily
XM_006236829.5 → XP_006236891.1 cytotoxic granule associated RNA binding protein TIA1 isoform X5

See identical proteins and their annotated locations for XP_006236891.1

UniProtKB/TrEMBL

A0A8I6AKZ8, A6IAW7

Conserved Domains (4) summary

cd12618
Location:105 → 184

RRM2_TIA1; RNA recognition motif 2 in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins

cd12620
Location:214 → 286

RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins

TIGR01661
Location:6 → 280

ELAV_HUD_SF; ELAV/HuD family splicing factor

cl17169
Location:8 → 81

RRM_SF; RNA recognition motif (RRM) superfamily
XM_063286066.1 → XP_063142136.1 cytotoxic granule associated RNA binding protein TIA1 isoform X2

UniProtKB/TrEMBL

A0A8I6AKZ8
XM_063286068.1 → XP_063142138.1 cytotoxic granule associated RNA binding protein TIA1 isoform X6

UniProtKB/TrEMBL

F7FKD5
XM_063286069.1 → XP_063142139.1 cytotoxic granule associated RNA binding protein TIA1 isoform X8
XM_063286071.1 → XP_063142141.1 cytotoxic granule associated RNA binding protein TIA1 isoform X9
XM_063286070.1 → XP_063142140.1 cytotoxic granule associated RNA binding protein TIA1 isoform X9
XM_063286072.1 → XP_063142142.1 cytotoxic granule associated RNA binding protein TIA1 isoform X9