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    Magohb mago homolog B, exon junction complex subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690303, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Magohbprovided by RGD
    Official Full Name
    mago homolog B, exon junction complex subunitprovided by RGD
    Primary source
    RGD:1597384
    See related
    EnsemblRapid:ENSRNOG00000010316 AllianceGenome:RGD:1597384
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in mRNA splicing, via spliceosome and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in neuronal cell body. Orthologous to human MAGOHB (mago homolog B, exon junction complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 60.3), Thymus (RPKM 37.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Magohb in Genome Data Viewer
    Location:
    4q42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (166765558..166773406, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (165034131..165041977, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (165514584..165522366, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor, subfamily A, member 2 Neighboring gene uncharacterized LOC108350878 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene serine/threonine/tyrosine kinase 1 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene Y box binding protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An Atomic Structure of the Human Spliceosome. Zhang X, et al. Cell, 2017 May 18. PMID 28502770
    2. Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay. Singh KK, et al. RNA Biol, 2013 Aug. PMID 23917022, Free PMC Article
    3. The ever-increasing complexities of the exon junction complex. Tange TØ, et al. Curr Opin Cell Biol, 2004 Jun. PMID 15145352
    4. The mammalian RNA-binding protein Staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons. Monshausen M, et al. Neuromolecular Med, 2004. PMID 15970630
    5. Structure of a human catalytic step I spliceosome. Zhan X, et al. Science, 2018 Feb 2. PMID 29301961

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type catalytic step 1 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exon-exon junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exon-exon junction complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of exon-exon junction subcomplex mago-y14 ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein mago nashi homolog 2
    Names
    mago homolog B, exon junction complex core component
    mago-nashi homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191105.1 → NP_001178034.1  protein mago nashi homolog 2

      See identical proteins and their annotated locations for NP_001178034.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IM92, F1M0X6
      Related
      ENSRNOP00000063195.2, ENSRNOT00000064420.5
      Conserved Domains (1) summary
      cd11295
      Location:6 → 148
      Mago_nashi; Mago nashi proteins, integral members of the exon junction complex

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      166765558..166773406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008763424.4 → XP_008761646.1  protein mago nashi homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_008761646.1

      UniProtKB/TrEMBL
      A6IM94
      Conserved Domains (1) summary
      cl03715
      Location:1 → 102
      Mago_nashi; Mago nashi proteins, integral members of the exon junction complex

    RNA

    1. XR_005503315.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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