Cnr1 cannabinoid receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cnr1provided by RGD
Official Full Name: cannabinoid receptor 1provided by RGD
Primary source: RGD:2369
See related: EnsemblRapid:ENSRNOG00000008223 AllianceGenome:RGD:2369
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CB1; CB-R; CB1R; SKR6R
Summary: Enables cannabinoid receptor activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of acute inflammatory response; and regulation of secretion by cell. Located in membrane raft and plasma membrane. Used to study several diseases, including Parkinsonism; diabetic neuropathy; impotence; obesity; and peptic ulcer disease. Biomarker of alcohol use disorder; obesity; and status epilepticus. Human ortholog(s) of this gene implicated in obesity; schizophrenia; and type 2 diabetes mellitus. Orthologous to human CNR1 (cannabinoid receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 374.6), Adrenal (RPKM 99.1) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (53204867..53230396)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (48408543..48436099)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (49307584..49333064)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparative assessment of CacyBP/SIP, beta-catenin and cannabinoid receptors in the adrenals of hypertensive rats.
Title: Comparative assessment of CacyBP/SIP, β-catenin and cannabinoid receptors in the adrenals of hypertensive rats.
Fatty Acid Amide Hydrolase and Cannabinoid Receptor Type 1 Genes Regulation is Modulated by Social Isolation in Rats.
Title: Fatty Acid Amide Hydrolase and Cannabinoid Receptor Type 1 Genes Regulation is Modulated by Social Isolation in Rats.
Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat model.
Title: Activation of CB1R alleviates central sensitization by regulating HCN2-pNR2B signaling in a chronic migraine rat model.
Dominance status is associated with a variation in cannabinoid receptor 1 expression and amphetamine reward.
Title: Dominance status is associated with a variation in cannabinoid receptor 1 expression and amphetamine reward.
Inulin may prevent steatosis by suppressing cannabinoid receptor-1 and patatin-like phospholipase-3 expression in liver.
Title: Inulin may prevent steatosis by suppressing cannabinoid receptor-1 and patatin-like phospholipase-3 expression in liver.
Endogenous Cannabinoid Receptors Modulate Plasticity at Immature Synapses.
Title: Endogenous Cannabinoid Receptors Modulate Plasticity at Immature Synapses.
Estrogen dampens central cannabinoid receptor 1-mediated neuroexcitation and pressor response in conscious female rats.
Title: Estrogen dampens central cannabinoid receptor 1-mediated neuroexcitation and pressor response in conscious female rats.
Blockage of ventrolateral periaqueductal gray matter cannabinoid 1 receptor increases dental pulp pain and pain-related subsequent learning and memory deficits in rats.
Title: Blockage of ventrolateral periaqueductal gray matter cannabinoid 1 receptor increases dental pulp pain and pain-related subsequent learning and memory deficits in rats.
Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1.
Title: Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1.
Overexpression of miR-338-5p in exosomes derived from mesenchymal stromal cells provides neuroprotective effects by the Cnr1/Rap1/Akt pathway after spinal cord injury in rats.
Title: Overexpression of miR-338-5p in exosomes derived from mesenchymal stromal cells provides neuroprotective effects by the Cnr1/Rap1/Akt pathway after spinal cord injury in rats.

Submit: New GeneRIF Correction See all GeneRIFs (289)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:482606 (e-PCR)
- UniSTS:482606

Cnr1 (e-PCR), detects polymorphism
- UniSTS:141363

PMC123076P1 (e-PCR)
- UniSTS:270436

BE121087 (e-PCR)
- UniSTS:248015

PMC166293P1 (e-PCR)
- UniSTS:271579

BE120265 (e-PCR)
- UniSTS:247282

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cannabinoid receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cannabinoid receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within axonal fasciculation	ISO Inferred from Sequence Orthology more info
involved_in cannabinoid signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cannabinoid signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maternal process involved in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in memory	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dopamine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mast cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of monoatomic ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of nitric-oxide synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of serotonin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of acute inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fever generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of penile erection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nicotine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in retrograde trans-synaptic signaling by endocannabinoid	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cannabinoid receptor 1

Names: Cannabinoid CB1 receptor; brain-type cannabinoid receptor; cannabinoid receptor 1 (brain)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429314.1 → NP_001416243.1 cannabinoid receptor 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P20272

UniProtKB/TrEMBL

A6IIL9
NM_001429315.1 → NP_001416244.1 cannabinoid receptor 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P20272

UniProtKB/TrEMBL

A6IIL9
NM_001429316.1 → NP_001416245.1 cannabinoid receptor 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P20272

UniProtKB/TrEMBL

A6IIL9
NM_001429317.1 → NP_001416246.1 cannabinoid receptor 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P20272

UniProtKB/TrEMBL

A6IIL9
NM_012784.6 → NP_036916.1 cannabinoid receptor 1

See identical proteins and their annotated locations for NP_036916.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P20272

UniProtKB/TrEMBL

A6IIL9

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

53204867..53230396

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017593151.3 → XP_017448640.1 cannabinoid receptor 1 isoform X1

Related

ENSRNOP00000085179.1, ENSRNOT00000101534.2

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_039109284.2 → XP_038965212.1 cannabinoid receptor 1 isoform X1

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_063287170.1 → XP_063143240.1 cannabinoid receptor 1 isoform X1
XM_006237984.5 → XP_006238046.1 cannabinoid receptor 1 isoform X1

Conserved Domains (1) summary

cd15340
Location:118 → 409

7tmA_CB1; cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_063287167.1 → XP_063143237.1 cannabinoid receptor 1 isoform X1

UniProtKB/Swiss-Prot

P20272

UniProtKB/TrEMBL

A6IIL9

Related

ENSRNOP00000010850.1, ENSRNOT00000010850.4
XM_063287169.1 → XP_063143239.1 cannabinoid receptor 1 isoform X1

UniProtKB/Swiss-Prot

P20272

UniProtKB/TrEMBL

A6IIL9

Related

ENSRNOP00000081243.1, ENSRNOT00000099728.2
XM_063287168.1 → XP_063143238.1 cannabinoid receptor 1 isoform X1

UniProtKB/Swiss-Prot

P20272

UniProtKB/TrEMBL

A6IIL9

Related

ENSRNOP00000107575.1, ENSRNOT00000123144.1