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    Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366508, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Pik3cdprovided by RGD
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit deltaprovided by RGD
    Primary source
    RGD:1310990
    See related
    EnsemblRapid:ENSRNOG00000016846 AllianceGenome:RGD:1310990
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in negative regulation of gene expression. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Predicted to be active in cytoplasm and plasma membrane. Used to study schizophrenia. Human ortholog(s) of this gene implicated in colorectal cancer; endometrial cancer; immunodeficiency 14; and schizophrenia. Orthologous to human PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 363.9), Thymus (RPKM 286.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pik3cd in Genome Data Viewer
    Location:
    5q36
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (165377994..165426620, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (160094952..160142962, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (166602053..166628028, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene catenin, beta-interacting protein 1 Neighboring gene calsyntenin 1 Neighboring gene uncharacterized LOC120103039 Neighboring gene transmembrane protein 201 Neighboring gene solute carrier family 25 member 33 Neighboring gene uncharacterized LOC102548220

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Aberrant methylation of ERBB pathway genes in sporadic colorectal cancer. Szmida E, et al. J Appl Genet, 2015 May. PMID 25366420, Free PMC Article
    2. Inhibition of mitochondrial fission alters neo-intimal hyperplasia via PI3K/Akt signaling in arteriovenous fistulas. Wang F, et al. Vascular, 2023 Jun. PMID 35130772
    3. The p110δ isoforme of phosphatidylinositol 3-kinase plays an important role in host defense against chlamydial lung infection through influencing CD4+ T-cell function. Qiao S, et al. Pathog Dis, 2018 Aug 1. PMID 29893841
    4. The catalytic phosphoinositol 3-kinase isoform p110δ is required for glioma cell migration and invasion. Luk SK, et al. Eur J Cancer, 2012 Jan. PMID 22079609
    5. PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes. Pearce VQ, et al. J Immunol, 2015 Oct 1. PMID 26311905, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of SEMP1 Contributes to Improving the Biological Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia.
      Title: Upregulation of SEMP1 Contributes to Improving the Biological Functions of Trophoblast via the PI3K/AKT Pathway in Preeclampsia.
    2. Inhibition of mitochondrial fission alters neo-intimal hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
      Title: Inhibition of mitochondrial fission alters neo-intimal hyperplasia via PI3K/Akt signaling in arteriovenous fistulas.
    3. BAFF/BAFF-R involved in autoantibody production in rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin.
      Title: BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within B cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within defense response to fungus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial tube formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neutrophil apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class IA ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
    Names
    catalytic phosphatidylinositol 3-kinase delta
    phosphatidylinositol 3-kinase catalytic delta polypeptide
    phosphoinositide-3-kinase, catalytic, delta polypeptide
    NP_001102448.1
    XP_038966422.1
    XP_038966423.1
    XP_038966424.1
    XP_038966425.1
    XP_038966426.1
    XP_038966427.1
    XP_038966428.1
    XP_038966429.1
    XP_038966430.1
    XP_038966431.1
    XP_038966432.1
    XP_038966433.1
    XP_063144203.1
    XP_063144204.1
    XP_063144205.1
    XP_063144206.1
    XP_063144207.1
    XP_063144208.1
    XP_063144209.1
    XP_063144210.1
    XP_063144211.1
    XP_063144212.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108978.1 → NP_001102448.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

      See identical proteins and their annotated locations for NP_001102448.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6IUB9, D4A5Q1
      Related
      ENSRNOP00000061674.2, ENSRNOT00000066179.4
      Conserved Domains (5) summary
      cd08693
      Location:314 → 481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:507 → 628
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      pfam00794
      Location:182 → 281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain
      cl21453
      Location:620 → 942
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      165377994..165426620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288141.1 → XP_063144211.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X9

    2. XM_039110505.2 → XP_038966433.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X8

      Conserved Domains (5) summary
      cd08693
      Location:308 → 475
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:498 → 681
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:673 → 1040
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182 → 275
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    3. XM_039110504.2 → XP_038966432.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X7

      Conserved Domains (5) summary
      cd08693
      Location:314 → 481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:505 → 683
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:675 → 1041
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182 → 281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    4. XM_039110501.2 → XP_038966429.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4

      Conserved Domains (5) summary
      cd08693
      Location:314 → 481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:505 → 686
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:678 → 1044
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182 → 281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    5. XM_039110500.2 → XP_038966428.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3

      Conserved Domains (5) summary
      cd08693
      Location:314 → 481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:505 → 686
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:678 → 1045
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182 → 281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    6. XM_039110503.2 → XP_038966431.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X6

      Conserved Domains (5) summary
      cd08693
      Location:314 → 481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504 → 684
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:676 → 1042
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182 → 281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    7. XM_039110502.2 → XP_038966430.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5

      Conserved Domains (5) summary
      cd08693
      Location:314 → 481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504 → 684
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:676 → 1043
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182 → 281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    8. XM_039110499.2 → XP_038966427.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y949
      Conserved Domains (5) summary
      cd08693
      Location:314 → 481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504 → 687
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:679 → 1045
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182 → 281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    9. XM_039110494.2 → XP_038966422.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      Conserved Domains (5) summary
      cd08693
      Location:314 → 481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504 → 687
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:679 → 1046
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182 → 281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    10. XM_063288133.1 → XP_063144203.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

    11. XM_063288137.1 → XP_063144207.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5

    12. XM_039110495.2 → XP_038966423.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      Conserved Domains (5) summary
      cd08693
      Location:314 → 481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504 → 687
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:679 → 1046
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182 → 281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    13. XM_063288138.1 → XP_063144208.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X6

    14. XM_039110496.2 → XP_038966424.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      Conserved Domains (5) summary
      cd08693
      Location:314 → 481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504 → 687
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:679 → 1046
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182 → 281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    15. XM_063288136.1 → XP_063144206.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y949

    16. XM_063288140.1 → XP_063144210.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X6

    17. XM_039110498.2 → XP_038966426.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      Conserved Domains (5) summary
      cd08693
      Location:314 → 481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504 → 687
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:679 → 1046
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182 → 281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    18. XM_039110497.2 → XP_038966425.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      Conserved Domains (5) summary
      cd08693
      Location:314 → 481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504 → 687
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:679 → 1046
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182 → 281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32 → 107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    19. XM_063288142.1 → XP_063144212.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X9

    20. XM_063288134.1 → XP_063144204.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y949

    21. XM_063288139.1 → XP_063144209.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X6

    22. XM_063288135.1 → XP_063144205.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y949
      Related
      ENSRNOP00000076811.1, ENSRNOT00000095643.2
    Nucleotide Protein Strain
    Heading Accession and Version

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