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    Dglucy D-glutamate cyclase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362769, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dglucyprovided by RGD
    Official Full Name
    D-glutamate cyclaseprovided by RGD
    Primary source
    RGD:1311756
    See related
    EnsemblRapid:ENSRNOG00000004442 AllianceGenome:RGD:1311756
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311756
    Summary
    Predicted to enable D-glutamate cyclase activity. Predicted to be involved in glutamate metabolic process. Predicted to be located in mitochondrial matrix. Orthologous to human DGLUCY (D-glutamate cyclase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 117.9), Adrenal (RPKM 56.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dglucy in Genome Data Viewer
    Location:
    6q32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (125785075..125860496)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (120055480..120130910)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (124786164..124870244)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase A5 Neighboring gene polycomb group ring finger 5 like 1 Neighboring gene uncharacterized LOC134479467 Neighboring gene uncharacterized LOC120103602 Neighboring gene G protein-coupled receptor 68 Neighboring gene coiled-coil domain containing 88C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. (D)-Glutamate is metabolized in the heart mitochondria. Ariyoshi M, et al. Sci Rep, 2017 Mar 7. PMID 28266638, Free PMC Article
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-glutamate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-glutamate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutamate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D-glutamate cyclase, mitochondrial
    Names
    UPF0317 protein C14orf159 homolog, mitochondrial
    NP_001167028.1
    XP_006240503.1
    XP_006240504.1
    XP_017449723.1
    XP_038968459.1
    XP_038968460.1
    XP_038968461.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173557.1 → NP_001167028.1  D-glutamate cyclase, mitochondrial

      See identical proteins and their annotated locations for NP_001167028.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZU77
      Conserved Domains (2) summary
      pfam07286
      Location:116 → 256
      DUF1445; Protein of unknown function (DUF1445)
      pfam14336
      Location:300 → 610
      DUF4392; Domain of unknown function (DUF4392)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      125785075..125860496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240441.5 → XP_006240503.1  D-glutamate cyclase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006240503.1

      UniProtKB/TrEMBL
      A0A8I5ZU77
      Related
      ENSRNOP00000112030.1, ENSRNOT00000126596.1
      Conserved Domains (2) summary
      pfam07286
      Location:116 → 256
      DUF1445; Protein of unknown function (DUF1445)
      pfam14336
      Location:300 → 610
      DUF4392; Domain of unknown function (DUF4392)

    2. XM_039112532.2 → XP_038968460.1  D-glutamate cyclase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZU77
      Conserved Domains (2) summary
      pfam07286
      Location:116 → 256
      DUF1445; Protein of unknown function (DUF1445)
      pfam14336
      Location:300 → 610
      DUF4392; Domain of unknown function (DUF4392)

    3. XM_006240442.4 → XP_006240504.1  D-glutamate cyclase, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006240504.1

      UniProtKB/TrEMBL
      A0A8I5ZU77
      Conserved Domains (2) summary
      pfam07286
      Location:116 → 256
      DUF1445; Protein of unknown function (DUF1445)
      pfam14336
      Location:300 → 610
      DUF4392; Domain of unknown function (DUF4392)

    4. XM_039112531.2 → XP_038968459.1  D-glutamate cyclase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZU77
      Related
      ENSRNOP00000082039.2, ENSRNOT00000117375.2
      Conserved Domains (2) summary
      pfam07286
      Location:116 → 256
      DUF1445; Protein of unknown function (DUF1445)
      pfam14336
      Location:300 → 610
      DUF4392; Domain of unknown function (DUF4392)

    5. XM_017594234.2 → XP_017449723.1  D-glutamate cyclase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZU77, D4A9W3
      Related
      ENSRNOP00000005903.6, ENSRNOT00000005903.9
      Conserved Domains (2) summary
      pfam07286
      Location:130 → 270
      DUF1445; Protein of unknown function (DUF1445)
      pfam14336
      Location:314 → 624
      DUF4392; Domain of unknown function (DUF4392)

    6. XM_039112533.2 → XP_038968461.1  D-glutamate cyclase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZU77
      Conserved Domains (2) summary
      pfam07286
      Location:2 → 142
      DUF1445; Protein of unknown function (DUF1445)
      pfam14336
      Location:186 → 496
      DUF4392; Domain of unknown function (DUF4392)
    Nucleotide Protein Strain
    Heading Accession and Version

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