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    Med16 mediator complex subunit 16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299607, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Med16provided by RGD
    Official Full Name
    mediator complex subunit 16provided by RGD
    Primary source
    RGD:1308001
    See related
    EnsemblRapid:ENSRNOG00000011315 AllianceGenome:RGD:1308001
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Thrap5
    Summary
    Predicted to enable nuclear thyroid hormone receptor binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of transcription initiation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED16 (mediator complex subunit 16). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 65.5), Heart (RPKM 62.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Med16 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10449273..10461797)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9798641..9811172)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12619739..12632241)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene R3H domain containing 4 Neighboring gene U6 spliceosomal RNA Neighboring gene complement factor D Neighboring gene elastase, neutrophil expressed

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. Ito M, et al. EMBO J, 2002 Jul 1. PMID 12093747, Free PMC Article
    2. A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. Wang Q, et al. J Biol Chem, 2002 Nov 8. PMID 12218053
    3. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Ito M, et al. Mol Cell, 1999 Mar. PMID 10198638
    4. The Mediator complex and transcription regulation. Poss ZC, et al. Crit Rev Biochem Mol Biol, 2013 Nov-Dec. PMID 24088064, Free PMC Article
    5. The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. Kang YK, et al. Proc Natl Acad Sci U S A, 2002 Mar 5. PMID 11867769, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 16
    Names
    thyroid hormone receptor associated protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106768.1 → NP_001100238.1  mediator of RNA polymerase II transcription subunit 16

      See identical proteins and their annotated locations for NP_001100238.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474029
      UniProtKB/TrEMBL
      A6K8V2, D3ZHA9
      Related
      ENSRNOP00000076087.3, ENSRNOT00000093264.3
      Conserved Domains (4) summary
      smart00320
      Location:95 → 134
      WD40; WD40 repeats
      COG2319
      Location:85 → 280
      WD40; WD40 repeat [General function prediction only]
      pfam11635
      Location:144 → 858
      Med16; Mediator complex subunit 16
      sd00039
      Location:62 → 104
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10449273..10461797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240861.5 → XP_006240923.1  mediator of RNA polymerase II transcription subunit 16 isoform X3

      UniProtKB/TrEMBL
      D3ZHA9
      Conserved Domains (4) summary
      smart00320
      Location:95 → 134
      WD40; WD40 repeats
      COG2319
      Location:85 → 280
      WD40; WD40 repeat [General function prediction only]
      pfam11635
      Location:144 → 886
      Med16; Mediator complex subunit 16
      sd00039
      Location:62 → 104
      7WD40; WD40 repeat [structural motif]

    2. XM_063263165.1 → XP_063119235.1  mediator of RNA polymerase II transcription subunit 16 isoform X5

    3. XM_063263167.1 → XP_063119237.1  mediator of RNA polymerase II transcription subunit 16 isoform X8

    4. XM_006240862.5 → XP_006240924.1  mediator of RNA polymerase II transcription subunit 16 isoform X4

      UniProtKB/TrEMBL
      D3ZHA9
      Conserved Domains (4) summary
      smart00320
      Location:94 → 133
      WD40; WD40 repeats
      COG2319
      Location:84 → 279
      WD40; WD40 repeat [General function prediction only]
      pfam11635
      Location:143 → 885
      Med16; Mediator complex subunit 16
      sd00039
      Location:61 → 103
      7WD40; WD40 repeat [structural motif]

    5. XM_006240864.5 → XP_006240926.1  mediator of RNA polymerase II transcription subunit 16 isoform X6

      UniProtKB/TrEMBL
      D3ZHA9
      Related
      ENSRNOP00000015257.8, ENSRNOT00000015257.8
      Conserved Domains (4) summary
      smart00320
      Location:94 → 133
      WD40; WD40 repeats
      COG2319
      Location:84 → 279
      WD40; WD40 repeat [General function prediction only]
      pfam11635
      Location:143 → 857
      Med16; Mediator complex subunit 16
      sd00039
      Location:61 → 103
      7WD40; WD40 repeat [structural motif]

    6. XM_039078637.2 → XP_038934565.1  mediator of RNA polymerase II transcription subunit 16 isoform X2

      UniProtKB/TrEMBL
      D3ZHA9
      Conserved Domains (3) summary
      smart00320
      Location:59 → 98
      WD40; WD40 repeats
      sd00039
      Location:26 → 68
      7WD40; WD40 repeat [structural motif]
      pfam11635
      Location:108 → 822
      Med16; Mediator complex subunit 16

    7. XM_063263168.1 → XP_063119238.1  mediator of RNA polymerase II transcription subunit 16 isoform X2

      Related
      ENSRNOP00000072279.2, ENSRNOT00000080089.3

    8. XM_063263166.1 → XP_063119236.1  mediator of RNA polymerase II transcription subunit 16 isoform X7

    9. XM_006240865.5 → XP_006240927.1  mediator of RNA polymerase II transcription subunit 16 isoform X7

      See identical proteins and their annotated locations for XP_006240927.1

      UniProtKB/TrEMBL
      A0A0G2K2K5
      Conserved Domains (3) summary
      smart00320
      Location:59 → 98
      WD40; WD40 repeats
      sd00039
      Location:26 → 68
      7WD40; WD40 repeat [structural motif]
      pfam11635
      Location:108 → 850
      Med16; Mediator complex subunit 16

    10. XM_006240866.5 → XP_006240928.1  mediator of RNA polymerase II transcription subunit 16 isoform X7

      See identical proteins and their annotated locations for XP_006240928.1

      UniProtKB/TrEMBL
      A0A0G2K2K5
      Conserved Domains (3) summary
      smart00320
      Location:59 → 98
      WD40; WD40 repeats
      sd00039
      Location:26 → 68
      7WD40; WD40 repeat [structural motif]
      pfam11635
      Location:108 → 850
      Med16; Mediator complex subunit 16

    11. XM_063263164.1 → XP_063119234.1  mediator of RNA polymerase II transcription subunit 16 isoform X1

    12. XM_039078641.2 → XP_038934569.2  mediator of RNA polymerase II transcription subunit 16 isoform X11

    13. XM_063263169.1 → XP_063119239.1  mediator of RNA polymerase II transcription subunit 16 isoform X9

    14. XM_039078640.2 → XP_038934568.1  mediator of RNA polymerase II transcription subunit 16 isoform X10

      Conserved Domains (1) summary
      pfam11635
      Location:14 → 527
      Med16; Mediator complex subunit 16
    Nucleotide Protein Strain
    Heading Accession and Version

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