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    Wiz WIZ zinc finger [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314598, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Wizprovided by RGD
    Official Full Name
    WIZ zinc fingerprovided by RGD
    Primary source
    RGD:1307771
    See related
    EnsemblRapid:ENSRNOG00000006217 AllianceGenome:RGD:1307771
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including SET domain binding activity; histone methyltransferase binding activity; and transcription corepressor binding activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication; protein stabilization; and regulation of transcription by RNA polymerase II. Predicted to be located in midbody and nucleoplasm. Predicted to be active in nucleus. Orthologous to human WIZ (WIZ zinc finger). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 29.0), Adrenal (RPKM 26.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wiz in Genome Data Viewer
    Location:
    7q11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (12017374..12045812, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (11366837..11395279, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (14374358..14402647, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene A-kinase anchoring protein 8 like Neighboring gene uncharacterized LOC134479821 Neighboring gene RAS protein activator like 3 Neighboring gene uncharacterized LOC134479820 Neighboring gene peptidoglycan recognition protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A proteomic characterization of factors enriched at nascent DNA molecules. Lopez-Contreras AJ, et al. Cell Rep, 2013 Apr 25. PMID 23545495, Free PMC Article
    2. Aberrantly Methylated-Differentially Expressed Genes Identify Novel Atherosclerosis Risk Subtypes. Xue Y, et al. Front Genet, 2020. PMID 33381146, Free PMC Article
    3. Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP. Ueda J, et al. J Biol Chem, 2006 Jul 21. PMID 16702210
    4. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SET domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone methyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of nuclear cell cycle DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein Wiz
    Names
    widely-interspaced zinc finger motifs

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427399.1 → NP_001414328.1  protein Wiz

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      Related
      ENSRNOP00000080016.2, ENSRNOT00000103303.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      12017374..12045812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080037.2 → XP_038935965.1  protein Wiz isoform X7

      Conserved Domains (3) summary
      PHA03247
      Location:852 → 1221
      PHA03247; large tegument protein UL36; Provisional
      PHA03321
      Location:941 → 1083
      PHA03321; tegument protein VP11/12; Provisional
      sd00017
      Location:316 → 336
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_039080036.2 → XP_038935964.1  protein Wiz isoform X6

      Conserved Domains (2) summary
      PHA03247
      Location:859 → 1389
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:316 → 336
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_039080033.2 → XP_038935961.1  protein Wiz isoform X3

      Related
      ENSRNOP00000106516.1, ENSRNOT00000134108.1
      Conserved Domains (2) summary
      PHA03321
      Location:1239 → 1381
      PHA03321; tegument protein VP11/12; Provisional
      sd00017
      Location:316 → 336
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_039080035.2 → XP_038935963.1  protein Wiz isoform X5

      Related
      ENSRNOP00000107859.1, ENSRNOT00000132626.1
      Conserved Domains (3) summary
      PHA03247
      Location:1026 → 1446
      PHA03247; large tegument protein UL36; Provisional
      PHA03321
      Location:1166 → 1308
      PHA03321; tegument protein VP11/12; Provisional
      sd00017
      Location:316 → 336
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_063263401.1 → XP_063119471.1  protein Wiz isoform X2

    6. XM_008765163.4 → XP_008763385.1  protein Wiz isoform X1

      See identical proteins and their annotated locations for XP_008763385.1

      Conserved Domains (2) summary
      PHA03321
      Location:1296 → 1438
      PHA03321; tegument protein VP11/12; Provisional
      sd00017
      Location:316 → 336
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_017594800.3 → XP_017450289.1  protein Wiz isoform X1

      Conserved Domains (2) summary
      PHA03321
      Location:1296 → 1438
      PHA03321; tegument protein VP11/12; Provisional
      sd00017
      Location:316 → 336
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. XM_039080029.2 → XP_038935957.1  protein Wiz isoform X1

      Conserved Domains (2) summary
      PHA03321
      Location:1296 → 1438
      PHA03321; tegument protein VP11/12; Provisional
      sd00017
      Location:316 → 336
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. XM_039080038.2 → XP_038935966.1  protein Wiz isoform X8

      Conserved Domains (1) summary
      PHA03321
      Location:570 → 712
      PHA03321; tegument protein VP11/12; Provisional

    10. XM_039080040.2 → XP_038935968.1  protein Wiz isoform X10

      Conserved Domains (1) summary
      PHA03321
      Location:513 → 655
      PHA03321; tegument protein VP11/12; Provisional

    11. XM_063263404.1 → XP_063119474.1  protein Wiz isoform X13

    12. XM_039080044.2 → XP_038935972.1  protein Wiz isoform X18

      Conserved Domains (1) summary
      PHA03321
      Location:215 → 357
      PHA03321; tegument protein VP11/12; Provisional

    13. XM_039080042.2 → XP_038935970.1  protein Wiz isoform X15

      UniProtKB/TrEMBL
      A6K947, D3ZQQ2
      Related
      ENSRNOP00000008303.4, ENSRNOT00000008303.7
      Conserved Domains (2) summary
      PHA03247
      Location:133 → 663
      PHA03247; large tegument protein UL36; Provisional
      PHA03321
      Location:383 → 525
      PHA03321; tegument protein VP11/12; Provisional

    14. XM_063263406.1 → XP_063119476.1  protein Wiz isoform X15

      UniProtKB/TrEMBL
      A6K947, D3ZQQ2

    15. XM_039080031.2 → XP_038935959.1  protein Wiz isoform X1

      Conserved Domains (2) summary
      PHA03321
      Location:1296 → 1438
      PHA03321; tegument protein VP11/12; Provisional
      sd00017
      Location:316 → 336
      ZF_C2H2; C2H2 Zn finger [structural motif]

    16. XM_017594801.3 → XP_017450290.1  protein Wiz isoform X1

      Conserved Domains (2) summary
      PHA03321
      Location:1296 → 1438
      PHA03321; tegument protein VP11/12; Provisional
      sd00017
      Location:316 → 336
      ZF_C2H2; C2H2 Zn finger [structural motif]

    17. XM_039080032.2 → XP_038935960.1  protein Wiz isoform X2

      Conserved Domains (3) summary
      PHA03247
      Location:963 → 1524
      PHA03247; large tegument protein UL36; Provisional
      PHA03321
      Location:1244 → 1386
      PHA03321; tegument protein VP11/12; Provisional
      sd00017
      Location:264 → 284
      ZF_C2H2; C2H2 Zn finger [structural motif]

    18. XM_008765161.4 → XP_008763383.1  protein Wiz isoform X1

      See identical proteins and their annotated locations for XP_008763383.1

      Conserved Domains (2) summary
      PHA03321
      Location:1296 → 1438
      PHA03321; tegument protein VP11/12; Provisional
      sd00017
      Location:316 → 336
      ZF_C2H2; C2H2 Zn finger [structural motif]

    19. XM_063263403.1 → XP_063119473.1  protein Wiz isoform X12

    20. XM_063263402.1 → XP_063119472.1  protein Wiz isoform X9

    21. XM_063263407.1 → XP_063119477.1  protein Wiz isoform X17

    22. XM_063263405.1 → XP_063119475.1  protein Wiz isoform X14

    23. XM_017594803.3 → XP_017450292.1  protein Wiz isoform X4

      Conserved Domains (3) summary
      PHA03247
      Location:887 → 1448
      PHA03247; large tegument protein UL36; Provisional
      PHA03321
      Location:1168 → 1310
      PHA03321; tegument protein VP11/12; Provisional
      sd00017
      Location:188 → 208
      ZF_C2H2; C2H2 Zn finger [structural motif]

    24. XM_039080034.1 → XP_038935962.1  protein Wiz isoform X4

      Conserved Domains (3) summary
      PHA03247
      Location:887 → 1448
      PHA03247; large tegument protein UL36; Provisional
      PHA03321
      Location:1168 → 1310
      PHA03321; tegument protein VP11/12; Provisional
      sd00017
      Location:188 → 208
      ZF_C2H2; C2H2 Zn finger [structural motif]

    25. XM_039080043.2 → XP_038935971.1  protein Wiz isoform X16

      Conserved Domains (1) summary
      PHA03321
      Location:347 → 489
      PHA03321; tegument protein VP11/12; Provisional

    26. XM_039080041.2 → XP_038935969.1  protein Wiz isoform X11

      UniProtKB/TrEMBL
      A0A8I6AH19
      Related
      ENSRNOP00000093209.1, ENSRNOT00000109179.2
      Conserved Domains (1) summary
      PHA03321
      Location:477 → 619
      PHA03321; tegument protein VP11/12; Provisional

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108064.1: Suppressed sequence

      Description
      NM_001108064.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: WIZ (GeneID:58525).
    Nucleotide Protein Strain
    Heading Accession and Version

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