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    Csad cysteine sulfinic acid decarboxylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60356, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Csadprovided by RGD
    Official Full Name
    cysteine sulfinic acid decarboxylaseprovided by RGD
    Primary source
    RGD:621030
    See related
    EnsemblRapid:ENSRNOG00000011573 AllianceGenome:RGD:621030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables sulfinoalanine decarboxylase activity. Involved in L-cysteine catabolic process to hypotaurine and L-cysteine catabolic process to taurine. Located in cytoplasm. Orthologous to human CSAD (cysteine sulfinic acid decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 476.4), Kidney (RPKM 261.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Csad in Genome Data Viewer
    Location:
    7q36
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135187175..135216495, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133308571..133337914, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143781520..143810880, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor binding protein 6 Neighboring gene sterol O-acyltransferase 2 Neighboring gene zinc finger protein 740 Neighboring gene integrin subunit beta 7 Neighboring gene uncharacterized LOC134479582 Neighboring gene retinoic acid receptor, gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the cDNA coding for rat brain cysteine sulfinate decarboxylase: brain and liver enzymes are identical proteins encoded by two distinct mRNAs. Tappaz M, et al. J Neurochem, 1999 Sep. PMID 10461879
    2. Cysteine sulfinate decarboxylase (CSD): molecular cloning, sequence and genomic expression in brain. Tappaz M, et al. Adv Exp Med Biol, 1998. PMID 9635011
    3. Immunocytochemical localization of cysteine sulfinate decarboxylase in astrocytes in the cerebellum and hippocampus: a quantitative double immunofluorescence study with glial fibrillary acidic protein and S-100 protein. Reymond I, et al. Neuroscience, 1996 Nov. PMID 8931024
    4. Molecular cloning and sequence analysis of the cDNA encoding rat liver cysteine sulfinate decarboxylase (CSD). Reymond I, et al. Biochim Biophys Acta, 1996 Jun 7. PMID 8679699
    5. Cloning and characterization of rat cysteine sulfinic acid decarboxylase. Kaisaki PJ, et al. Biochim Biophys Acta, 1995 May 17. PMID 7772604

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aspartate 1-decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfinoalanine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfinoalanine decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-cysteine catabolic process to hypotaurine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-cysteine catabolic process to taurine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in taurine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in taurine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within taurine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in taurine biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    cysteine sulfinic acid decarboxylase
    Names
    aspartate 1-decarboxylase
    cysteine-sulfinate decarboxylase
    sulfinoalanine decarboxylase
    NP_068518.1
    XP_006242500.1
    XP_006242501.1
    XP_006242502.1
    XP_038935762.1
    XP_038935763.1
    XP_038935766.1
    XP_063120254.1
    XP_063120255.1
    XP_063120256.1
    XP_063120257.1
    XP_063120258.1
    XP_063120260.1
    XP_063120261.1
    XP_063120262.1
    XP_063120263.1
    XP_063120264.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021750.3 → NP_068518.1  cysteine sulfinic acid decarboxylase

      See identical proteins and their annotated locations for NP_068518.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q546T1, Q64577, Q64611, Q9R1F6
      UniProtKB/TrEMBL
      A6KCT1, B3VPA7
      Related
      ENSRNOP00000073508.3, ENSRNOT00000079678.3
      Conserved Domains (1) summary
      cd06450
      Location:89 → 489
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      135187175..135216495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264193.1 → XP_063120263.1  cysteine sulfinic acid decarboxylase isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZQK7

    2. XM_063264191.1 → XP_063120261.1  cysteine sulfinic acid decarboxylase isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZQK7

    3. XM_039079838.2 → XP_038935766.1  cysteine sulfinic acid decarboxylase isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q7U2, B3VPA7
      Conserved Domains (1) summary
      cd06450
      Location:68 → 468
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

    4. XM_063264188.1 → XP_063120258.1  cysteine sulfinic acid decarboxylase isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q7U2, B3VPA7

    5. XM_006242438.5 → XP_006242500.1  cysteine sulfinic acid decarboxylase isoform X1

      See identical proteins and their annotated locations for XP_006242500.1

      UniProtKB/Swiss-Prot
      Q546T1, Q64577, Q64611, Q9R1F6
      UniProtKB/TrEMBL
      A6KCT1, B3VPA7
      Conserved Domains (1) summary
      cd06450
      Location:89 → 489
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

    6. XM_006242440.5 → XP_006242502.1  cysteine sulfinic acid decarboxylase isoform X1

      See identical proteins and their annotated locations for XP_006242502.1

      UniProtKB/Swiss-Prot
      Q546T1, Q64577, Q64611, Q9R1F6
      UniProtKB/TrEMBL
      A6KCT1, B3VPA7
      Conserved Domains (1) summary
      cd06450
      Location:89 → 489
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

    7. XM_063264184.1 → XP_063120254.1  cysteine sulfinic acid decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      Q546T1, Q64577, Q64611, Q9R1F6
      UniProtKB/TrEMBL
      A6KCT1, B3VPA7

    8. XM_063264192.1 → XP_063120262.1  cysteine sulfinic acid decarboxylase isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZQK7

    9. XM_039079835.2 → XP_038935763.1  cysteine sulfinic acid decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      Q546T1, Q64577, Q64611, Q9R1F6
      UniProtKB/TrEMBL
      A6KCT1, B3VPA7
      Conserved Domains (1) summary
      cd06450
      Location:89 → 489
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

    10. XM_063264190.1 → XP_063120260.1  cysteine sulfinic acid decarboxylase isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q7U2, B3VPA7

    11. XM_063264194.1 → XP_063120264.1  cysteine sulfinic acid decarboxylase isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZQK7

    12. XM_006242439.4 → XP_006242501.1  cysteine sulfinic acid decarboxylase isoform X1

      See identical proteins and their annotated locations for XP_006242501.1

      UniProtKB/Swiss-Prot
      Q546T1, Q64577, Q64611, Q9R1F6
      UniProtKB/TrEMBL
      A6KCT1, B3VPA7
      Conserved Domains (1) summary
      cd06450
      Location:89 → 489
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

    13. XM_063264186.1 → XP_063120256.1  cysteine sulfinic acid decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      Q546T1, Q64577, Q64611, Q9R1F6
      UniProtKB/TrEMBL
      A6KCT1, B3VPA7

    14. XM_039079834.2 → XP_038935762.1  cysteine sulfinic acid decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      Q546T1, Q64577, Q64611, Q9R1F6
      UniProtKB/TrEMBL
      A6KCT1, B3VPA7
      Conserved Domains (1) summary
      cd06450
      Location:89 → 489
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

    15. XM_063264187.1 → XP_063120257.1  cysteine sulfinic acid decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      Q546T1, Q64577, Q64611, Q9R1F6
      UniProtKB/TrEMBL
      A6KCT1, B3VPA7

    16. XM_063264185.1 → XP_063120255.1  cysteine sulfinic acid decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      Q546T1, Q64577, Q64611, Q9R1F6
      UniProtKB/TrEMBL
      A6KCT1, B3VPA7

    RNA

    1. XR_010053037.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001134454.1: Suppressed sequence

      Description
      NM_001134454.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64611.1 GenPept UniProtKB/Swiss-Prot:Q64611

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