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    Matk megakaryocyte-associated tyrosine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60450, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Matkprovided by RGD
    Official Full Name
    megakaryocyte-associated tyrosine kinaseprovided by RGD
    Primary source
    RGD:69058
    See related
    EnsemblRapid:ENSRNOG00000020431 AllianceGenome:RGD:69058
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Batk
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human MATK (megakaryocyte-associated tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 166.5), Spleen (RPKM 46.0) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Matk in Genome Data Viewer
    Location:
    7q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9107711..9116864, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8456990..8465947, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11325246..11334311, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tight junction protein 3 Neighboring gene amyloid beta precursor protein binding family A member 3 Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene zinc finger RNA binding protein 2 Neighboring gene ATCAY kinesin light chain interacting caytaxin Neighboring gene uncharacterized LOC134479805

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Purification, crystallization, small-angle X-ray scattering and preliminary X-ray diffraction analysis of the SH2 domain of the Csk-homologous kinase. Gunn NJ, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Mar 1. PMID 21393838, Free PMC Article
    2. Identification and characterization of Batk, a predominantly brain-specific non-receptor protein tyrosine kinase related to Csk. Kuo SS, et al. J Neurosci Res, 1994 Aug 15. PMID 7807586
    3. Csk-homologous kinase interacts with SHPS-1 and enhances neurite outgrowth of PC12 cells. Mitsuhashi H, et al. J Neurochem, 2008 Apr. PMID 17999719
    4. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, et al. Mamm Genome, 2000 Sep. PMID 10967130
    5. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The CHK SH2 was expressed in Escherichia coli and the purified protein was characterized as monomeric by synchrotron small-angle X-ray scattering in-line with size-exclusion chromatography.
      Title: Purification, crystallization, small-angle X-ray scattering and preliminary X-ray diffraction analysis of the SH2 domain of the Csk-homologous kinase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105436

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    megakaryocyte-associated tyrosine-protein kinase
    Names
    megakaryocyte-associated tyrosine kinase (non-receptor protein tyrosine kinase)
    non-receptor protein kinase protein
    protein kinase BATK
    tyrosine-protein kinase CTK
    NP_068631.1
    XP_038935769.1
    XP_038935770.1
    XP_038935771.1
    XP_038935772.1
    XP_038935773.1
    XP_063120269.1
    XP_063120270.1
    XP_063120271.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021859.2 → NP_068631.1  megakaryocyte-associated tyrosine-protein kinase

      See identical proteins and their annotated locations for NP_068631.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087726
      UniProtKB/Swiss-Prot
      P41243
      UniProtKB/TrEMBL
      A0A8I6GLP3, A6K8A4
      Related
      ENSRNOP00000027730.4, ENSRNOT00000027730.6
      Conserved Domains (3) summary
      cd09937
      Location:77 → 174
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl17036
      Location:9 → 67
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:187 → 441
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      9107711..9116864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264200.1 → XP_063120270.1  megakaryocyte-associated tyrosine-protein kinase isoform X3

      UniProtKB/Swiss-Prot
      P41243
      UniProtKB/TrEMBL
      A0A8I6GLP3, A6K8A4

    2. XM_039079842.2 → XP_038935770.1  megakaryocyte-associated tyrosine-protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLP3
      Conserved Domains (3) summary
      cd09937
      Location:77 → 174
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl17036
      Location:9 → 67
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:187 → 470
      PKc_like; Protein Kinases, catalytic domain

    3. XM_063264201.1 → XP_063120271.1  megakaryocyte-associated tyrosine-protein kinase isoform X4

      UniProtKB/TrEMBL
      A0A8I6GLP3

    4. XM_039079845.2 → XP_038935773.1  megakaryocyte-associated tyrosine-protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A8I6GLP3
      Conserved Domains (3) summary
      cl15255
      Location:77 → 163
      SH2; Src homology 2 (SH2) domain
      cl17036
      Location:9 → 67
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:176 → 459
      PKc_like; Protein Kinases, catalytic domain

    5. XM_063264199.1 → XP_063120269.1  megakaryocyte-associated tyrosine-protein kinase isoform X3

      UniProtKB/Swiss-Prot
      P41243
      UniProtKB/TrEMBL
      A0A8I6GLP3, A6K8A4

    6. XM_039079841.2 → XP_038935769.1  megakaryocyte-associated tyrosine-protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLP3
      Conserved Domains (3) summary
      cd09937
      Location:77 → 174
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl17036
      Location:9 → 67
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:187 → 470
      PKc_like; Protein Kinases, catalytic domain

    7. XM_039079844.2 → XP_038935772.1  megakaryocyte-associated tyrosine-protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLP3
      Conserved Domains (3) summary
      cd09937
      Location:77 → 174
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl17036
      Location:9 → 67
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:187 → 470
      PKc_like; Protein Kinases, catalytic domain

    8. XM_039079843.2 → XP_038935771.1  megakaryocyte-associated tyrosine-protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLP3
      Conserved Domains (3) summary
      cd09937
      Location:77 → 174
      SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)
      cl17036
      Location:9 → 67
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:187 → 470
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41243.1 GenPept UniProtKB/Swiss-Prot:P41243

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